Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study | SpringerLink

https://link.springer.com/article/10.1007/s11011-017-0088-z



"Both diet groups showed significant improvement in ATEC and CARS scores in comparison to control group, yet ketogenic scored better results in cognition and sociability compared to GFCF diet group."



El-Rashidy, O., El-Baz, F., El-Gendy, Y. et al. Metab Brain Dis (2017). https://doi.org/10.1007/s11011-017-0088-z

Study Puts Smart Drugs Back in Spotlight | Adolescent Medicine | JAMA | The JAMA Network

http://jamanetwork.com/journals/jama/fullarticle/2649239

"A group of 39 highly rated male members of the German Chess Federation were enlisted to play more than 3000 15-minute games against computers matched to their skill levels while taking modafinil, methylphenidate, or caffeine. The researchers reported that players taking modafinil and methylphenidate won more games overall, though they pondered their moves longer, causing them to sometimes lose on time."

"The positive association surprised Lieb. “Our hypothesis [had been] that it’s not possible to enhance subjects who are already working at top performance,” he said."

Lyon J. Chess Study Revives Debate Over Cognition-Enhancing Drugs. JAMA. Published online August 16, 2017. doi:10.1001/jama.2017.8114

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0178-2

"Conclusions

Optimization of dosing, timing, and scheduling of the press-pulse therapeutic strategy will facilitate the eradication of tumor cells with minimal patient toxicity. This therapeutic strategy can be used as a framework for the design of clinical trials for the non-toxic management of most cancers."

Press-pulse: a novel therapeutic strategy for the metabolic management of cancerThomas N. SeyfriedEmail author, George Yu, Joseph C. Maroon and Dominic P. D’AgostinoNutrition & Metabolism201714:19https://doi.org/10.1186/s12986-017-0178-2©  The Author(s). 2017Received: 29 September 2016Accepted: 17 February 2017Published: 23 February 2017

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Brain metabolism in health, aging, and neurodegeneration. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28438892/



"Emerging findings suggest that lifestyles that include intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, can increase the likelihood that the brain will function optimally and in the absence of disease throughout life."



EMBO J. 2017 Apr 24. pii: e201695810. doi: 10.15252/embj.201695810.

Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort - the 45 and Up Study. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28040519/



"We found no evidence that following a vegetarian diet, semi-vegetarian diet or a pesco-vegetarian diet has an independent protective effect on all-cause mortality."


Prev Med. 2017 Apr;97:1-7. doi: 10.1016/j.ypmed.2016.12.044. Epub 2016 Dec 29.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia | Stroke

http://stroke.ahajournals.org/content/48/5/1139



Conclusions—Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia

Matthew P. Pase, Jayandra J. Himali, Alexa S. Beiser, Hugo J. Aparicio, Claudia L. Satizabal, Ramachandran S. Vasan, Sudha Seshadri and Paul F. Jacques

Stroke. 2017;48:1139-1146, originally published April 24, 2017

 https://doi.org/10.1161/STROKEAHA.116.016027

Sugar addiction: pushing the drug-sugar analogy to the limit. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/23719144



"Overall, this research has revealed that sugar and sweet reward can not only substitute to addictive drugs, like cocaine, but can even be more rewarding and attractive."

Sugar addiction: pushing the drug-sugar analogy to the limit.Ahmed SH, Guillem K, Vandaele Y.Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8. Review.

The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/


Conclusions

Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.

Kasielski, M., Eusebio, M.-O., Pietruczuk, M., & Nowak, D. (2015). The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat. Nutrition Journal, 15, 68. http://doi.org/10.1186/s12937-016-0189-2

Livsmedelsverket – EU:s nya huvudlaboratorium för virus i livsmedel

https://www.livsmedelsverket.se/om-oss/press/nyheter/pressmeddelanden/livsmedelsverket-eus-nya-huvudlaboratorium-for-virus-i-livsmedel



"Uppemot 180 000 svenskar drabbas årligen av vinterkräksjuka via livsmedel."

A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/25760553/



RESULTS: At the age of 13 y, ADHD or Asperge was diagnosed in 6/35 (17.1%) children in the placebo and none in the probiotic group.



Pediatr Res. 2015 Jun;77(6):823-8. doi: 10.1038/pr.2015.51. Epub 2015 Mar 11.

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/26046241/





FINDINGS: Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, and essential metabolites all convey information to the central nervous system about the intestinal state. Conversely, the hypothalamic-pituitary-adrenal axis, the central nervous system regulatory areas of satiety, and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions seem to influence the pathogenesis of a number of disorders in which inflammation is implicated, such as mood disorder, autism-spectrum disorders, attention-deficit hypersensitivity disorder, multiple sclerosis, and obesity.



Clin Ther. 2015 May 1;37(5):984-95. doi: 10.1016/j.clinthera.2015.04.002.

Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease | Niknamian | International Science and Investigation journal

http://isijournal.info/journals/index.php/ISIJ/article/view/252/197



Abstract

This review takes a deep look at increases in the incidence of cancer and heart disease after
the introduction of industrial vegetable oils in the world. Most vegetable oils are highly
processed and refined products, which completely lack the essential nutrients. Omega-6
Linoleic acid from vegetable oils increases oxidative stress in the body of humans, contributing
to endothelial dysfunction and heart disease. The consumption of these harmful oils which are
high in mega-6 polyunsaturated fats results in changing the structure of cell membrane which
contribute to increasing inflammation and the incidence of cancer.



Niknamian, S., & Kalamian, M. (2016). Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease. International Science And Investigation Journal, 5(5), 157-168. Retrieved from http://isijournal.info/journals/index.php/ISIJ/article/view/252/197

Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes | SpringerLink

http://link.springer.com/article/10.1007/s10545-016-0011-5


Conclusion

Ketogenic diet was an effective and safe treatment for the majority of patients. Treatment effect was mainly determined by disease phenotype and attainment and maintenance of ketosis.

Sofou, K., Dahlin, M., Hallböök, T. et al. J Inherit Metab Dis (2017). doi:10.1007/s10545-016-0011-5

Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide : Scientific Reports

http://www.nature.com/articles/srep39328





Abstract:

The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q < 0.05) were involved in organonitrogen metabolism and fatty acid β-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis. The metabolome analysis (55 metabolites altered out of 673 detected, p < 0.05) confirmed lipotoxic conditions and oxidative stress by showing an activation of glutathione and ascorbate free radical scavenger systems. Additionally, we found metabolite alterations associated with hallmarks of hepatotoxicity such as γ-glutamyl dipeptides, acylcarnitines, and proline derivatives. Overall, metabolome and proteome disturbances showed a substantial overlap with biomarkers of non-alcoholic fatty liver disease and its progression to steatohepatosis and thus confirm liver functional dysfunction resulting from chronic ultra-low dose GBH exposure.

• Scientific Reports 7, Article number: 39328 (2017)

• doi:10.1038/srep39328