SLEEP - Sleep and Antibody Response to Hepatitis B Vaccination

http://www.journalsleep.org/ViewAbstract.aspx?pid=28593

Conclusions:

"Short sleep duration in the natural environment may negatively affect in vivo antibody responses to novel antigens, providing a possible explanation for observed associations of poor sleep with increased susceptibility to infectious disease."

Prather AA; Hall M; Fury JM; Ross DC; Muldoon MF; Cohen S; Marsland AL. Sleep and antibody response to hepatitis B vaccination. SLEEP 2012;35(8):1063-1069.

Sleep and immune function

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256323/

Abstract

Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep–wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep facilitates the extravasation of T cells and their possible redistribution to lymph nodes. Moreover, such studies revealed a selectively enhancing influence of sleep on cytokines promoting the interaction between antigen presenting cells and T helper cells, like interleukin-12. Sleep on the night after experimental vaccinations against hepatitis A produced a strong and persistent increase in the number of antigen-specific Th cells and antibody titres. Together these findings indicate a specific role of sleep in the formation of immunological memory. This role appears to be associated in particular with the stage of slow wave sleep and the accompanying pro-inflammatory endocrine milieu that is hallmarked by high growth hormone and prolactin levels and low cortisol and catecholamine concentrations.

Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Archiv. 2012;463(1):121-137. doi:10.1007/s00424-011-1044-0.

Sleep Symptoms Associated with Intake of Specific Dietary Nutrients

Sleep Symptoms Associated with Intake of Specific Dietary Nutrients

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866235/

Abstract

Sleep symptoms are associated with weight gain and cardiometabolic disease. The potential role of diet has been largely unexplored. Data from the 2007–2008 NHANES were used (N=4,552) to determine which nutrients were associated with sleep symptoms in a nationally-representative sample. Survey items assessed difficulty falling asleep, sleep maintenance difficulties, non-restorative sleep, and daytime sleepiness. Analyses were adjusted for energy intake, other dietary factors, exercise, BMI and sociodemographics. Population-weighted, logistic regression, with backwards-stepwise selection, examined which nutrients were associated with sleep symptoms. Odds ratios (ORs) reflect the difference in odds of sleep symptoms associated with a doubling in nutrient. Nutrients that were independently associated with difficulty falling asleep included (in order): Alpha-Carotene (OR=0.96), Selenium (OR=0.80), Dodecanoic Acid (OR=0.91), Calcium (OR=0.83), and Hexadecanoic Acid (OR=1.10). Nutrients that were independently associated with sleep maintenance difficulties included: Salt (OR=1.19), Butanoic Acid (0,81), Carbohydrate (OR=0.71), Dodecanoic Acid (OR=0.90), Vitamin D (OR=0.84),, Lycopene (OR=0.98), Hexanoic Acid (OR= 1.25), and Moisture (OR=1.27). Nutrients that were independently associated with non-restorative sleep included Butanoic Acid (OR=1.09), Calcium (OR=0.81), Vitamin C (OR=0.92), Water (OR=0.98), Moisture (OR= 1.41), and Cholesterol (OR= 1.10). Nutrients that were independently associated with sleepiness included: Moisture (OR=1.20), Theobromine (OR=1.04), Potassium (OR= 0.70), Water (OR=0.97). These results suggest novel associations between sleep symptoms and diet/metabolism, potentially explaining associations between sleep and cardiometabolic diseases.

Smart Nutrition for Better Immune System

MP3 - http://dishingupnutrition.podbean.com/mf/web/wwspqv/dun_smart_nutrition_better_immune_function.mp3

www - http://www.weightandwellness.com

January 23 2010

Filed under: Health & Nutrition — dishingupnutrition @ 1:21 pm

Today’s show is all about the immune system and which foods supercharge your health and which foods suppress it. Licensed Nutritionists Darlene Kvist and Anna Derhak discuss how your serotonin and zinc levels affect both your immune system and eating habits. Also, Dar and Anna talk about the importance of vitamin D to your health and happiness!

02:10 - what you eat will affect your immune system

• fungicide is decreased for 5 hours after eating Sugar. Under a microscope they move in slow motion)

• Robert Crayhon: -What cryptonite is to Superman. Sugar is to our immune cells.

(Robert Crayhon's Nutrition Made Simple: A Comprehensive Guide to the Latest Findings in Optimal Nutrition)

06:25 - what suppresses your immune system:

• Sugar

• Alcohol
• Lack of sleep
• Lack of protein (ex Zink)

07:45 - stuffy nose after consuming Beer, (feels like a cold is coming on). This is due to yeast.

10:08 - Foods that boost the immunsystem

• Blueberry
• Brussels sprouts
• Kale
• Bell pepper
• Broccoli

• Tomatoes

13:49 - Healing the intestinal track

• Pro Biotic
• Bifital Bacteria
• Acidophilus , at bedtime, to get rid of candida

• Eliminate Sugar
• Digestive Enzyme, and little Hydrochloric acid

16:28 - Extrapolating from a In Vitro study into a Invivo study is a slippery slope. Many lab studies don't translate into human clinical studies

19:00 - Zink (73% is deficient in Zink)

• Body signs that tells you that you are low in Zinc
• Frequent colds
• Acne
• Slow wound healing
• Hair loss
• White spots on fingernails
• Fatigue
• Loss of taste
• Thyroid problem
• High sugar cravings right after a meal

25:00 - Whey Protein, comes from dairy

• Anti Viral
• Anti Bacterial
• Anti oxidant

26:00 - Vitamin-D

• Cancer protection
• Heart protection
• Immune function

• Protects against Colds

• Protects against Viruses
• Optimal range 50-100
• Sardines
• Grass fed butter
• Coded liver oil

32:20 - Zink

• 30-50 milligrams (if you are deficient)

•  

35:20 - Trans fats

• Pizza
• Muffin
• French fries
• Anything with partially hydrogenated fats or hydrogenated fats

40:25 - superhero fats

• Grass fed butter
• Coconut oil
• Olive oil
• Nuts
• 50 % if the cell membrane is Saturated fat That's in coconut oil or butter

End