fredag 28 augusti 2015

Antioxidants prevent health-promoting effects of physical exercise in humans - PNAS

Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.

Svenska via Google translate:
Tillskott med antioxidanter kan hindra dessa hälsofrämjande effekter av träning på människor.

Biological Sciences - Medical Sciences:
Michael Ristow, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C. Ronald Kahn, and Matthias Blüher

Antioxidants prevent health-promoting effects of physical exercise in humans
PNAS 2009 106 (21) 8665-8670; published ahead of print May 11, 2009, doi:10.1073/pnas.0903485106

Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. - PubMed - NCBI

Dietary cholesterol was not statistically significantly associated with any coronary artery disease...
ischemic stroke or hemorrhagic stroke.

Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.

Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis.
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ.
Am J Clin Nutr. 2015 Aug;102(2):276-94. doi: 10.3945/ajcn.114.100305. Epub 2015 Jun 24.
PMID: 26109578

måndag 17 augusti 2015

PLOS ONE: Man the Fat Hunter: The Demise of Homo erectus and the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr) Levant


The worldwide association of H. erectus with elephants is well documented and so is the preference of humans for fat as a source of energy. We show that rather than a matter of preference, H. erectus in the Levant was dependent on both elephants and fat for his survival. The disappearance of elephants from the Levant some 400 kyr ago coincides with the appearance of a new and innovative local cultural complex – the Levantine Acheulo-Yabrudian and, as is evident from teeth recently found in the Acheulo-Yabrudian 400-200 kyr site of Qesem Cave, the replacement of H. erectus by a new hominin. We employ a bio-energetic model to present a hypothesis that the disappearance of the elephants, which created a need to hunt an increased number of smaller and faster animals while maintaining an adequate fat content in the diet, was the evolutionary drive behind the emergence of the lighter, more agile, and cognitively capable hominins. Qesem Cave thus provides a rare opportunity to study the mechanisms that underlie the emergence of our post-erectus ancestors, the fat hunters.

CitationBen-Dor M, Gopher A, Hershkovitz I, Barkai R (2011)
Man the Fat Hunter: The Demise of 
Homo erectus and
the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr)
Levant. PLoS ONE 6(12): e28689. doi:10.1371/journal.pone.0028689

måndag 10 augusti 2015


Ayyadurai, V.A.S. and Deonikar, P. (2015) Do GMOs Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria? Systems Biology May Provide Answers. Agricultural Sciences6, 630-662. doi:10.4236/as.2015.67062.

Eat more salt and live longer (especially if you have had a cardiovascular event)

04:00 - Funnel plost - Publication Bias

08:20 - Causation vs Association Studies

09:50 - journal NEJM back in 1972
there is a bit of concern about the low salt diet. You can lower blood pressure okay nobody's disputing that but there's a price to pay, you're going to raise a renin and aldosterone levels  fairly substantially. So while you may lower your blood pressure you may actually put yourself at higher risk have coronary artery disease.

10:39 - Intrasalt Study (the main reason for recent advice to lower salt comsumption)

17:00 - Salt and Mortality.
If you eat less salt, you are more likely to die
As you take a high-salt diet your mortality, goes down
As you take more more salt, cardiovascular disease goes down

20:20 - People with high blood pressure, the people the guideline tells to eat less salt.
 Cardiovascular event rate for people as they take more more salt their cardiovascular  evnt rate goes down and down

23:20 - Journal of the American Medical Association
They took 3,685 people and they followed them for seven point nine year
You had 23 times increase in your cardiac event ray when you take a low-salt diet, it looks pretty bad

25:10 - Another cochran review
there was one group that it looked like urs actually very harmful to follow a low-salt diet back group was the cardiac patients, so the people with heart failure the ones I you all tell to eat a low salt diet, they seem to do much worse, much worse than everybody else

25:30 - Potential Harm From Too Little Salt Intake (The National Academies of Sciences)
Especially for those people with heart failure you want to be very very careful because the low salt diet might be extremely harmful to you okay it's not only not good for you but it might be actually very harmful to you and that everything else was that there was a really enough

Evidence indicates that low sodium intake may lead to risk of adverse health effects among those with mid- to late-stage heart failure who are receiving aggressive treatment for their disease

27:10 - Tradeoffs for low sodium intake
Blood Pressure - 3.85 % Decrease (best-case scenario)
Renin (hormone) + 24.3 % Increase
Aldosterone (hormone) + 24.5 % Increase
Adrenaline (hormone) + 9 % Increase

28:20 - The modern treatment for atherosclerosis
Renin - Renin inhibitors are used to treat hypertension
Aldosterone - spironolactone, ARBs & ACE Inhibitors are used to treat high levels of Aldosterone
Adrenaline - is blocked with Beta Blocker