Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/

Conclusion

Subclinical magnesium deficiency is a common and under-recognised problem throughout the world. Importantly, subclinical magnesium deficiency does not manifest as clinically apparent symptoms and thus is not easily recognised by the clinician. Despite this fact, subclinical magnesium deficiency likely leads to hypertension, arrhythmias, arterial calcifications, atherosclerosis, heart failure and an increased risk for thrombosis. This suggests that subclinical magnesium deficiency is a principal, yet under-recognised, driver of cardiovascular disease. 

Open Heart. 2018; 5(1): e000668. 

Published online 2018 Jan 13. doi: 10.1136/openhrt-2017-000668

PMCID: PMC5786912

PMID: 29387426

Nutritional factors in the prevention and management of coronary ar... - PubMed - NCBI

Nutritional factors in the prevention and management of coronary ar... - PubMed - NCBI

Abstract

"Nutritional factors such as magnesium, folic acid, vitamins B12 and B6, l-arginine, and polyunsaturated fatty acids (PUFAs) appear to be significantly beneficial for patients with coronary artery disease (CAD), and in the prevention and arresting the progression of HF and cardiac arrhythmias. Additionally, ingestion of adequate amounts of protein and maintaining normal concentrations of plasma albumin seem to be essential for these patients. These nutrients closely interact with the metabolism of l-arginine-nitric oxide (NO) system, essential fatty acids, and eicosanoids such that beneficial products such as NO, prostaglandin E1, prostacyclin, prostaglandin I3, lipoxins, resolvins, and protectins are generated and synthesis of proinflammatory cytokines is suppressed that results in platelet anti-aggregation, vasodilation, angiogenesis, and prevention of CAD, cardiac arrhythmias, and stabilization of HF. This implies that individuals at high risk for CAD, cardiac arrhythmias, and HF and those who have these diseases need to be screened for plasma levels of magnesium, folic acid, vitamins B12 and B6, l-arginine, NO, various PUFAs, lipoxin A4, resolvins, protectins, asymmetrical dimethylarginine (an endogenous inhibitor of NO), albumin, and various eicosanoids and cytokines and correct their abnormalities to restore normal physiology."

Das UN.

Nutrition. 2015 Feb;31(2):283-91. doi: 10.1016/j.nut.2014.08.011. Epub 2014 Sep 4. Review.

PMID:

 

25592005