tisdag 29 juni 2021

Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial

https://pubmed.ncbi.nlm.nih.gov/31700717/

Conclusion This study shows the short-term beneficial effects of carbohydrate-restricted diet on serum BDNF and executive function in those individuals characterized with MetS. We have shown that the addition of exercise can further improve neuroprotection and cognitive function beyond the results of diet alone.

Gyorkos A, Baker MH, Miutz LN, Lown DA, Jones MA, Houghton-Rahrig LD. Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial. Cureus. 2019 Sep 9;11(9):e5604. doi: 10.7759/cureus.5604. PMID: 31700717; PMCID: PMC6822553.



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söndag 6 juni 2021

Induction of ketosis as a potential therapeutic option to limit hyperglycemia and prevent cytokine storm in COVID-19

Källa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416786

”Abstract

The severe form of coronavirus disease 19 (COVID-19) is characterized by cytokine storm syndrome (CSS) and disseminated intravascular coagulation (DIC). Diabetes, obesity, and hypertension have, as minor common denominators, chronic low-grade inflammation and high plasma myeloperoxidase levels, which could be linked to pulmonary phagocytic hyperactivation and CSS. The hyperactivation of M1 macrophages with a proinflammatory phenotype, which is linked to aerobic glycolysis, leads to the recruitment of monocytes, neutrophils, and platelets from circulating blood and plays a crucial role in thrombo-inflammation (as recently demonstrated in COVID-19) through the formation of neutrophil extracellular traps and monocyte-platelet aggregates, which could be responsible for DIC. The modulation of glucose availability for activated M1 macrophages by means of a eucaloric ketogenic diet (EKD) could represent a possible metabolic tool for reducing adenosine triphosphate production from aerobic glycolysis in the M1 macrophage phenotype during the exudative phase. This approach could reduce the overproduction of cytokines and, consequently, the accumulation of neutrophils, monocytes, and platelets from the blood. Second, an EKD could be advantageous for the metabolism of anti-inflammatory M2 macrophages because these cells predominantly express oxidative phosphorylation enzymes and are best fed by the oxidation of fatty acids in the mitochondria. An EKD could guarantee the availability of free fatty acids, which are an optimal fuel supply for these cells. Third, an EKD, which could reduce high lactate formation by macrophages due to glycolysis, could favor the production of interferon type I, which are inhibited by excessive lactate production. From a practical point of view, the hypothesis, in addition to being proven in clinical studies, must obviously take into account the contraindications of an EKD, particularly type 1 or 2 diabetes treated with drugs that can cause hypoglycemia, to avoid the risk for side effects of the diet.”

Sukkar SG, Bassetti M. Induction of ketosis as a potential therapeutic option to limit hyperglycemia and prevent cytokine storm in COVID-19. Nutrition. 2020;79-80:110967. doi:10.1016/j.nut.2020.110967



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måndag 31 maj 2021

Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

 https://pubmed.ncbi.nlm.nih.gov/33668240/


 Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.


Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.

torsdag 27 maj 2021

Intermittent fasting in mice effective at promoting long term memory retention: Intermittent fasting in mice demonstrably more effective at promoting long term memory retention -- ScienceDaily

https://www.sciencedaily.com/releases/2021/05/210524215527.htm

 "Over the course of three months, the mice in the IF group demonstrated improved long-term memory retention compared to the other groups. When the brains of these mice were studied, it was apparent that the Klotho gene was upregulated, and neurogenesis increased compared to those that were on the CR diet." 

King's College London. (2021, May 24). Intermittent fasting in mice effective at promoting long term memory retention: Intermittent fasting in mice demonstrably more effective at promoting long term memory retention. ScienceDaily. Retrieved May 27, 2021 from www.sciencedaily.com/releases/2021/05/210524215527.htm

måndag 17 maj 2021

Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0167494320302855

 

"Taken together, these findings suggest that βOHB may be useful in combating hepatic cellular senescence induced by d-galactose or γ-irradiation via autophagy dependent mechanisms."


 Habieb, M. E., Mohamed, M. A., El Gamal, D. M., Hawas, A. M. & Mohamed, T. M. (2021). Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. Archives of Gerontology and Geriatrics, 92, s. 104288. doi:https://doi.org/10.1016/j.archger.2020.104288

STEM-talk Podcast - EPISODE 122: JAMES KIRKLAND ON TARGETING SENESCENT CELLS TO REVERSE AGE-RELATED DISEASES

 IHMC STEM-Talk Podcast Episode 122

 

"As senescent cells build up in the body, they promote cellular aging and a host of chronic conditions related to aging, such as dementia, cancer, atherosclerosis, diabetes and arthritis. In today’s interview, we focus on Jim’s 2015 study where he and his colleagues at Mayo were the first to report on the potential of senolytic drugs to selectively kill zombie senescent cells. Jim’s paper in Aging Cell has been hailed as a major breakthrough in aging research."



The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease - PubMed

https://pubmed.ncbi.nlm.nih.gov/25686106/


"Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome"


Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21(3):263-269. doi:10.1038/nm.3804

A drug that can stop tumors from growing -- ScienceDaily

https://www.sciencedaily.com/releases/2021/04/210407174307.htm

 

Summary:
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion.
 
 

 University of Colorado Anschutz Medical Campus. (2021, April 7). A drug that can stop tumors from growing. ScienceDaily. Retrieved May 16, 2021 from www.sciencedaily.com/releases/2021/04/210407174307.htm

måndag 12 april 2021

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation

 https://pubmed.ncbi.nlm.nih.gov/21673053/


 Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet.”

 Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression”


Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res. 2011 Jul 1;71(13):4484-93. doi: 10.1158/0008-5472.CAN-10-3973. Epub 2011 Jun 14. PMID: 21673053.


tisdag 2 mars 2021

Eating more refined grains increases risk of heart attack, early death

 

https://www.sciencedaily.com/releases/2021/02/210219155857.htm


 The study found that having more than seven servings of refined grains per day was associated with a 27 per cent greater risk for early death, 33 percent greater risk for heart disease and 47 per cent greater risk for stroke.”


Simon Fraser University. (2021, February 19). Eating more refined grains increases risk of heart attack, early death: The researchers examined diets from diverse populations in low, middle and high-income countries.. ScienceDaily. Retrieved March 2, 2021 from www.sciencedaily.com/releases/2021/02/210219155857.htm

torsdag 11 februari 2021

Children and adults should avoid consuming animal products to reduce risk for chronic disease: NO

 https://academic.oup.com/ajcn/article/112/4/931/5901950


”Restrictive dietary prescriptions that exclude animal products complicate the quest for optimal nutrition by undermining dietary diversity and flexibility, and by introducing a dependency on fortification and supplementation. Thus, a vegan diet may put the general population at increased risk of poor nutrition, a problem of particular concern for those with special nutritional requirements.”



Frédéric Leroy, Neal D Barnard, Children and adults should avoid consuming animal products to reduce risk for chronic disease: NO, The American Journal of Clinical Nutrition, Volume 112, Issue 4, October 2020, Pages 931–936, https://doi.org/10.1093/ajcn/nqaa236


torsdag 4 februari 2021

Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis - PubMed

https://pubmed.ncbi.nlm.nih.gov/32653422/

Conclusions: Our analysis suggests that higher consumption of eggs (more than 1 egg/day) was not associated with increased risk of cardiovascular disease, but was associated with a significant reduction in risk of coronary artery disease.  

Krittanawong C, Narasimhan B, Wang Z, Virk HUH, Farrell AM, Zhang H, Tang WHW. Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Am J Med. 2021 Jan;134(1):76-83.e2. doi: 10.1016/j.amjmed.2020.05.046. Epub 2020 Jul 10. PMID: 32653422.


Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

 https://pubmed.ncbi.nlm.nih.gov/27304506/


Abstract

Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from the prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which food consumption is restricted to certain hours of the day, allows the daily fasting period to last >12 hr, thus imparting pleiotropic benefits. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting-mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMDs, both basic science and translational research are warranted to develop fasting-associated interventions into feasible, effective, and inexpensive treatments with the potential to improve healthspan.

Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. PMID: 27304506; PMCID: PMC5388543.

torsdag 28 januari 2021

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/


Conclusion

Subclinical magnesium deficiency is a common and under-recognised problem throughout the world. Importantly, subclinical magnesium deficiency does not manifest as clinically apparent symptoms and thus is not easily recognised by the clinician. Despite this fact, subclinical magnesium deficiency likely leads to hypertension, arrhythmias, arterial calcifications, atherosclerosis, heart failure and an increased risk for thrombosis. This suggests that subclinical magnesium deficiency is a principal, yet under-recognised, driver of cardiovascular disease. 


Open Heart. 2018; 5(1): e000668. 
Published online 2018 Jan 13. doi: 10.1136/openhrt-2017-000668
PMCID: PMC5786912
PMID: 29387426