måndag 17 maj 2021

Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0167494320302855

 

"Taken together, these findings suggest that βOHB may be useful in combating hepatic cellular senescence induced by d-galactose or γ-irradiation via autophagy dependent mechanisms."


 Habieb, M. E., Mohamed, M. A., El Gamal, D. M., Hawas, A. M. & Mohamed, T. M. (2021). Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. Archives of Gerontology and Geriatrics, 92, s. 104288. doi:https://doi.org/10.1016/j.archger.2020.104288

STEM-talk Podcast - EPISODE 122: JAMES KIRKLAND ON TARGETING SENESCENT CELLS TO REVERSE AGE-RELATED DISEASES

 IHMC STEM-Talk Podcast Episode 122

 

"As senescent cells build up in the body, they promote cellular aging and a host of chronic conditions related to aging, such as dementia, cancer, atherosclerosis, diabetes and arthritis. In today’s interview, we focus on Jim’s 2015 study where he and his colleagues at Mayo were the first to report on the potential of senolytic drugs to selectively kill zombie senescent cells. Jim’s paper in Aging Cell has been hailed as a major breakthrough in aging research."



The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease - PubMed

https://pubmed.ncbi.nlm.nih.gov/25686106/


"Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome"


Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21(3):263-269. doi:10.1038/nm.3804

A drug that can stop tumors from growing -- ScienceDaily

https://www.sciencedaily.com/releases/2021/04/210407174307.htm

 

Summary:
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion.
 
 

 University of Colorado Anschutz Medical Campus. (2021, April 7). A drug that can stop tumors from growing. ScienceDaily. Retrieved May 16, 2021 from www.sciencedaily.com/releases/2021/04/210407174307.htm

måndag 12 april 2021

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation

 https://pubmed.ncbi.nlm.nih.gov/21673053/


 Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet.”

 Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression”


Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res. 2011 Jul 1;71(13):4484-93. doi: 10.1158/0008-5472.CAN-10-3973. Epub 2011 Jun 14. PMID: 21673053.


tisdag 2 mars 2021

Eating more refined grains increases risk of heart attack, early death

 

https://www.sciencedaily.com/releases/2021/02/210219155857.htm


 The study found that having more than seven servings of refined grains per day was associated with a 27 per cent greater risk for early death, 33 percent greater risk for heart disease and 47 per cent greater risk for stroke.”


Simon Fraser University. (2021, February 19). Eating more refined grains increases risk of heart attack, early death: The researchers examined diets from diverse populations in low, middle and high-income countries.. ScienceDaily. Retrieved March 2, 2021 from www.sciencedaily.com/releases/2021/02/210219155857.htm

torsdag 11 februari 2021

Children and adults should avoid consuming animal products to reduce risk for chronic disease: NO

 https://academic.oup.com/ajcn/article/112/4/931/5901950


”Restrictive dietary prescriptions that exclude animal products complicate the quest for optimal nutrition by undermining dietary diversity and flexibility, and by introducing a dependency on fortification and supplementation. Thus, a vegan diet may put the general population at increased risk of poor nutrition, a problem of particular concern for those with special nutritional requirements.”



Frédéric Leroy, Neal D Barnard, Children and adults should avoid consuming animal products to reduce risk for chronic disease: NO, The American Journal of Clinical Nutrition, Volume 112, Issue 4, October 2020, Pages 931–936, https://doi.org/10.1093/ajcn/nqaa236


torsdag 4 februari 2021

Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis - PubMed

https://pubmed.ncbi.nlm.nih.gov/32653422/

Conclusions: Our analysis suggests that higher consumption of eggs (more than 1 egg/day) was not associated with increased risk of cardiovascular disease, but was associated with a significant reduction in risk of coronary artery disease.  

Krittanawong C, Narasimhan B, Wang Z, Virk HUH, Farrell AM, Zhang H, Tang WHW. Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Am J Med. 2021 Jan;134(1):76-83.e2. doi: 10.1016/j.amjmed.2020.05.046. Epub 2020 Jul 10. PMID: 32653422.


Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

 https://pubmed.ncbi.nlm.nih.gov/27304506/


Abstract

Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from the prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which food consumption is restricted to certain hours of the day, allows the daily fasting period to last >12 hr, thus imparting pleiotropic benefits. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting-mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMDs, both basic science and translational research are warranted to develop fasting-associated interventions into feasible, effective, and inexpensive treatments with the potential to improve healthspan.

Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. PMID: 27304506; PMCID: PMC5388543.

torsdag 28 januari 2021

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/


Conclusion

Subclinical magnesium deficiency is a common and under-recognised problem throughout the world. Importantly, subclinical magnesium deficiency does not manifest as clinically apparent symptoms and thus is not easily recognised by the clinician. Despite this fact, subclinical magnesium deficiency likely leads to hypertension, arrhythmias, arterial calcifications, atherosclerosis, heart failure and an increased risk for thrombosis. This suggests that subclinical magnesium deficiency is a principal, yet under-recognised, driver of cardiovascular disease. 


Open Heart. 2018; 5(1): e000668. 
Published online 2018 Jan 13. doi: 10.1136/openhrt-2017-000668
PMCID: PMC5786912
PMID: 29387426


tisdag 19 januari 2021

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? - PubMed

https://pubmed.ncbi.nlm.nih.gov/21885251/

 

Abstract

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.

 

Seyfried TN, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26. doi: 10.1016/j.eplepsyres.2011.06.017. Epub 2011 Aug 31. PMID: 21885251.

 

måndag 28 december 2020

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

https://jamanetwork.com/journals/jama/fullarticle/2758712


”Six weeks after completing the modified ketogenic diet, patients had improved Alzheimer disease biomarkers in their cerebrospinal fluid. “With the ketogenic diet, we are moving the β-amyloid in a healthier direction,” Craft said. Patients also had better blood flow to the hippocampus and improved body-wide insulin sensitivity. A larger trial of the modified ketogenic diet is now under way.”


Kuehn BM. In Alzheimer Research, Glucose Metabolism Moves to Center Stage. JAMA.2020;323(4):297–299. doi:10.1001/jama.2019.20939


fredag 25 december 2020

“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub

Conclusion

"Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19."
 
 Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R. & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology, 203, s. 105751. doi:https://doi.org/10.1016/j.jsbmb.2020.105751

måndag 2 november 2020

Diet modulates brain network stability, a biomarker for brain aging, in young adults

 https://www.pnas.org/content/117/11/6170


”Targeted experiments show that this biomarker for brain aging is reliably modulated with consumption of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks.”


Listen to the Author Lilianne R. Mujica-Parodi talk about this paper at STEM-Talk podcast [00:59:33] into the podcast. https://podcasts.apple.com/se/podcast/stem-talk/id1091402153?i=1000496517254



Diet modulates brain network stability, a biomarker for brain aging, in young adults

Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, Kieran Clarke

Proceedings of the National Academy of Sciences Mar 2020, 117 (11) 6170-6177; DOI: 10.1073/pnas.1913042117