måndag 31 maj 2021

Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

 https://pubmed.ncbi.nlm.nih.gov/33668240/


 Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.


Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.

torsdag 27 maj 2021

Intermittent fasting in mice effective at promoting long term memory retention: Intermittent fasting in mice demonstrably more effective at promoting long term memory retention -- ScienceDaily

https://www.sciencedaily.com/releases/2021/05/210524215527.htm

 "Over the course of three months, the mice in the IF group demonstrated improved long-term memory retention compared to the other groups. When the brains of these mice were studied, it was apparent that the Klotho gene was upregulated, and neurogenesis increased compared to those that were on the CR diet." 

King's College London. (2021, May 24). Intermittent fasting in mice effective at promoting long term memory retention: Intermittent fasting in mice demonstrably more effective at promoting long term memory retention. ScienceDaily. Retrieved May 27, 2021 from www.sciencedaily.com/releases/2021/05/210524215527.htm

måndag 17 maj 2021

Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0167494320302855

 

"Taken together, these findings suggest that βOHB may be useful in combating hepatic cellular senescence induced by d-galactose or γ-irradiation via autophagy dependent mechanisms."


 Habieb, M. E., Mohamed, M. A., El Gamal, D. M., Hawas, A. M. & Mohamed, T. M. (2021). Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. Archives of Gerontology and Geriatrics, 92, s. 104288. doi:https://doi.org/10.1016/j.archger.2020.104288

STEM-talk Podcast - EPISODE 122: JAMES KIRKLAND ON TARGETING SENESCENT CELLS TO REVERSE AGE-RELATED DISEASES

 IHMC STEM-Talk Podcast Episode 122

 

"As senescent cells build up in the body, they promote cellular aging and a host of chronic conditions related to aging, such as dementia, cancer, atherosclerosis, diabetes and arthritis. In today’s interview, we focus on Jim’s 2015 study where he and his colleagues at Mayo were the first to report on the potential of senolytic drugs to selectively kill zombie senescent cells. Jim’s paper in Aging Cell has been hailed as a major breakthrough in aging research."



The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease - PubMed

https://pubmed.ncbi.nlm.nih.gov/25686106/


"Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome"


Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21(3):263-269. doi:10.1038/nm.3804

A drug that can stop tumors from growing -- ScienceDaily

https://www.sciencedaily.com/releases/2021/04/210407174307.htm

 

Summary:
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion.
 
 

 University of Colorado Anschutz Medical Campus. (2021, April 7). A drug that can stop tumors from growing. ScienceDaily. Retrieved May 16, 2021 from www.sciencedaily.com/releases/2021/04/210407174307.htm