onsdag 25 mars 2015

Novel treatment (new drug/intervention; established drug/procedure in new situation): Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus



A 5-year and 10-month old boy was diagnosed with classical type 1 diabetes mellitus (T1DM) without celiac disease. He started on a gluten-free diet after 2–3 week without need of insulin treatment. At the initiation of gluten-free diet, HbA1c was 7.8% and was stabilised at 5.8%–6.0% without insulin therapy. Fasting blood glucose was maintained at 4.0–5.0 mmol/l. At 16 months after diagnosis the fasting blood glucose was 4.1 mmol/l and after 20 months he is still without daily insulin therapy. There was no alteration in glutamic acid decarboxylase positivity. The gluten-free diet was safe and without side effects. The authors propose that the gluten-free diet has prolonged remission in this patient with T1DM and that further trials are indicated.

Natural cocoa consumption: Potential to reduce atherogenic factors? - PubMed - NCBI

Natural cocoa consumption: Potential to reduce atherogenic factors? - PubMed - NCBI 


Natural cocoa consumption resulted in a significant decrease in haptoglobin (P=.034), EMP concentration (P=.017) and monocyte CD62L (P=.047) in obese compared to overweight and normal-weight subjects. Natural cocoa consumption regardless of BMI group was associated with an 18% increase in high-density lipoprotein (P=.020) and a 60% decrease in EMPs (P=.047). Also, obese subjects experienced a 21% decrease in haptoglobin (P=.034) and a 24% decrease in monocyte CD62L expression in (P=.047) following 4 weeks of natural cocoa consumption. Collectively, these findings indicate that acute natural cocoa consumption was associated with decreased obesity-related disease risk.

tisdag 24 mars 2015

Food Additives Alter Gut Microbes, Cause Diseases in Mice - NIH Research Matters - National Institutes of Health (NIH)

Food Additives Alter Gut Microbes, Cause Diseases in Mice - NIH Research Matters - National Institutes of Health (NIH)


At a Glance

  • Common food additives called emulsifiers promoted colitis and metabolic syndrome in mice by altering gut microbes.
  • The findings suggest that certain food additives might play a role in the increasing incidence of obesity and chronic inflammatory bowel disease.

tisdag 10 mars 2015

Sleep Symptoms Associated with Intake of Specific Dietary Nutrients

Sleep Symptoms Associated with Intake of Specific Dietary Nutrients



Sleep symptoms are associated with weight gain and cardiometabolic disease. The potential role of diet has been largely unexplored. Data from the 2007–2008 NHANES were used (N=4,552) to determine which nutrients were associated with sleep symptoms in a nationally-representative sample. Survey items assessed difficulty falling asleep, sleep maintenance difficulties, non-restorative sleep, and daytime sleepiness. Analyses were adjusted for energy intake, other dietary factors, exercise, BMI and sociodemographics. Population-weighted, logistic regression, with backwards-stepwise selection, examined which nutrients were associated with sleep symptoms. Odds ratios (ORs) reflect the difference in odds of sleep symptoms associated with a doubling in nutrient. Nutrients that were independently associated with difficulty falling asleep included (in order): Alpha-Carotene (OR=0.96), Selenium (OR=0.80), Dodecanoic Acid (OR=0.91), Calcium (OR=0.83), and Hexadecanoic Acid (OR=1.10). Nutrients that were independently associated with sleep maintenance difficulties included: Salt (OR=1.19), Butanoic Acid (0,81), Carbohydrate (OR=0.71), Dodecanoic Acid (OR=0.90), Vitamin D (OR=0.84),, Lycopene (OR=0.98), Hexanoic Acid (OR= 1.25), and Moisture (OR=1.27). Nutrients that were independently associated with non-restorative sleep included Butanoic Acid (OR=1.09), Calcium (OR=0.81), Vitamin C (OR=0.92), Water (OR=0.98), Moisture (OR= 1.41), and Cholesterol (OR= 1.10). Nutrients that were independently associated with sleepiness included: Moisture (OR=1.20), Theobromine (OR=1.04), Potassium (OR= 0.70), Water (OR=0.97). These results suggest novel associations between sleep symptoms and diet/metabolism, potentially explaining associations between sleep and cardiometabolic diseases.

torsdag 5 mars 2015

Cardiovascular Diabetology | Full text | Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study



Our aim was to compare the effects of a Paleolithic ('Old Stone Age') diet and a diabetes diet as generally recommended on risk factors for cardiovascular disease in patients with type 2 diabetes not treated with insulin.


In a randomized cross-over study, 13 patients with type 2 diabetes, 3 women and 10 men, were instructed to eat a Paleolithic diet based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts; and a Diabetes diet designed in accordance with dietary guidelines during two consecutive 3-month periods. Outcome variables included changes in weight, waist circumference, serum lipids, C-reactive protein, blood pressure, glycated haemoglobin (HbA1c), and areas under the curve for plasma glucose and plasma insulin in the 75 g oral glucose tolerance test. Dietary intake was evaluated by use of 4-day weighed food records.


Study participants had on average a diabetes duration of 9 years, a mean HbA1c of 6,6% units by Mono-S standard and were usually treated with metformin alone (3 subjects) or metformin in combination with a sulfonylurea (3 subjects) or a thiazolidinedione (3 subjects). Mean average dose of metformin was 1031 mg per day. Compared to the diabetes diet, the Paleolithic diet resulted in lower mean values of HbA1c (-0.4% units, = 0.01), triacylglycerol (-0.4 mmol/L, = 0.003), diastolic blood pressure (-4 mmHg, = 0.03), weight (-3 kg, = 0.01), BMI (-1 kg/m2p= 0.04) and waist circumference (-4 cm, = 0.02), and higher mean values of high density lipoprotein cholesterol (+0.08 mmol/L, = 0.03). The Paleolithic diet was mainly lower in cereals and dairy products, and higher in fruits, vegetables, meat and eggs, as compared with the Diabetes diet. Further, the Paleolithic diet was lower in total energy, energy density, carbohydrate, dietary glycemic load, saturated fatty acids and calcium, and higher in unsaturated fatty acids, dietary cholesterol and several vitamins. Dietary GI was slightly lower in the Paleolithic diet (GI = 50) than in the Diabetic diet (GI = 55).


Over a 3-month study period, a Paleolithic diet improved glycemic control and several cardiovascular risk factors compared to a Diabetes diet in patients with type 2 diabetes.

Red meats: Time for a paradigm shift in dietary advice

Red meats: Time for a paradigm shift in dietary advice



  • Dietary advice to limit red meat is unnecessarily restrictive and may have unintended health consequences.
  • Overzealous focus on limiting red meat may have distracted from effective nutrition strategies to address chronic diseases.
  • With increasing intakes of highly processed foods it is important to reconsider nutrition priorities.


Recent evidence suggests dietary advice to limit red meat is unnecessarily restrictive and may have unintended health consequences. As nutrient-rich high quality protein foods, red meats can play an important role in helping people meet their essential nutrient needs. Yet dietary advice to limit red meat remains standard in many developed countries, even though red meat intakes appear to be within current guidelines. Meanwhile, energy intakes from processed foods have increased dramatically at the expense of nutrient-rich foods, such as red meat. Research suggests these food trends are associated with the growing burden of obesity and associated diseases in recent decades. It is time for dietary advice that emphasizes the value of unprocessed red meat as part of a healthy balanced diet.

måndag 2 mars 2015

A dodecylamine derivative of cyanocobalamin potently inhibits the a... - PubMed - NCBI

A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans - PubMed - NCBI



In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficiency, were significantly increased in C


These results indicate that the cyanocobalamin-dodecylamine derivative acts as a potent inhibitor of cobalamin-dependent enzymes and induces severe cobalamin deficiency in C. elegans.