Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

 https://pubmed.ncbi.nlm.nih.gov/33668240/

” Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.”

Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.

“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub

Conclusion

"Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19."

 

 Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R. & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology, 203, s. 105751. doi:https://doi.org/10.1016/j.jsbmb.2020.105751

Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths - PubMed

https://pubmed.ncbi.nlm.nih.gov/32252338/



"To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L)."

Grant WB, Lahore H,
McDonnell SL, et al. Evidence that Vitamin D Supplementation Could
Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):E988. Published 2020 Apr 2. doi:10.3390/nu12040988

Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293152/



"Total vitamin D intake ≥400 versus <400 IU/d was associated with a lower risk of total lung cancer among participants who received the CARET active intervention (HR=0.56, 95% CI=0.32–0.99) and among those who had total vitamin A intake ≥1,500 μg/d Retinol Activity Equivalent (RAE; HR=0.46, 95% CI=0.23–0.91). The beneficial associations were attenuated among those who did not receive the CARET active intervention or who had total vitamin A intake <1,500 μg/d RAE (P-interaction=0.02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers."



Cheng T-YD, Goodman GE, Thornquist MD, et al. Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.International journal of cancer Journal international du cancer. 2014;135(9):2135-2145. doi:10.1002/ijc.28846.

Vitamin K2, Vitamin D, and Calcium: A Winning Combo

http://articles.mercola.com/sites/articles/archive/2012/12/16/vitamin-k2.aspx

Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/22001128

Sunlight Holds Key To Killing Breast Cancer | GreenMedInfo | Blog Entry

Sunlight Holds Key To Killing Breast Cancer | GreenMedInfo | Blog Entry

http://www.greenmedinfo.com/blog/sunlight-holds-key-killing-breast-cancer-3

Vitamin D Intake and Risk of Type 1 Diabetes: A Meta-Analysis of Observational Studies

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798920/

Conclusions

Our findings suggest that vitamin D intake during early life is associated with a reduced risk of type 1 diabetes. There was not enough evidence supporting an association between maternal intake of vitamin D and type 1 diabetes risk in the offspring. Because these findings were largely based upon case-control studies, well-designed cohort studies are still needed to determine the role of vitamin D in the prevention of type 1 diabetes.

Vitamin D and the risk of dementia and Alzheimer disease

Vitamin D and the risk of dementia and Alzheimer disease

• Vitamin D deficiency and the risk of dementia
  Howland Robert H | Published August 28, 2014

Conclusion: Our results confirm that vitamin D deficiency is associated with a substantially

increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate
about the role of vitamin D in nonskeletal conditions.

Neurology® 2014;83:1–9

New Study (2012) Confirms Biochemical Reasons Vitamin D Fights Cancers

http://www.michaelmooney.net/NewStudyConfirmsBiochemicalReasonsVitaminDFightsCancers.html

Vitamin D deficiency: a worldwide problem with health consequences

Vitamin D deficiency: a worldwide problem with health consequences

Abstract

Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Very few foods naturally contain vitamin D, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement. Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults. Vitamin D deficiency has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases. A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D's beneficial effects for health. In the absence of adequate sun exposure, at least 800–1000 IU vitamin D3/d may be needed to achieve this in children and adults. Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations.

Vitamin D - Why You are Probably NOT Getting Enough - Dr. Mark Hyman

Vitamin D - Why You are Probably NOT Getting Enough - Dr. Mark Hyman

Effects of 12weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency – a double-blind, randomized, placebo-controlled trial - Metabolism - Clinical and Experimental

http://www.metabolismjournal.com/article/S0026-0495(14)00175-9/abstract


Ökad vitamin-D Status förbättrar inte insulinresistens

Link between vitamin D, dementia risk confirmed

http://www.sciencedaily.com/releases/2014/08/140806161659.htm

Meta-analysis: Vitamin D supplementation reduces specific inflammatorymarker

http://www.vitamindcouncil.org/blog/meta-analysis-vitamin-d-supplementation-reduces-specific-inflammatory-marker/?mc_cid=3e1b321425&mc_eid=1d72be5c3b

Cholesterol – Fundamental for Life | David Perlmutter M.D.

Cholesterol – Fundamental for Life | David Perlmutter M.D.