http://www.ncbi.nlm.nih.gov/pubmed/21450549
RESULTS:
"Urine levels of BPA and DEHP metabolites decreased significantly during the fresh foods intervention [e.g., BPA geometric mean (GM), 3.7 ng/mL preintervention vs. 1.2 ng/mL during intervention; mono-(2-ethyl-5-hydroxy hexyl) phthalate GM, 57 ng/mL vs. 25 ng/mL]. The intervention reduced GM concentrations of BPA by 66% and DEHP metabolites by 53-56%. Maxima were reduced by 76% for BPA and 93-96% for DEHP metabolites."
CONCLUSIONS:
"BPA and DEHP exposures were substantially reduced when participants' diets were restricted to food with limited packaging."
Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention.
Rudel RA, Gray JM, Engel CL, Rawsthorne TW, Dodson RE, Ackerman JM, Rizzo J, Nudelman JL, Brody JG.
Environ Health Perspect. 2011 Jul;119(7):914-20. doi: 10.1289/ehp.1003170. Epub 2011 Mar 30.
PMID: 21450549
måndag 8 augusti 2016
The contribution of diet to total bisphenol A body burden in humans: results of a 48 hour fasting study. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/23026348
The contribution of diet to total bisphenol A body burden in humans: results of a 48 hour fasting study.
Christensen KL, Lorber M, Koslitz S, Brüning T, Koch HM.
Environ Int. 2012 Dec 1;50:7-14. doi: 10.1016/j.envint.2012.09.002. Epub 2012 Sep 29.
PMID: 23026348
onsdag 6 juli 2016
Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/m/pubmed/22840388/
CONCLUSION: "Preliminary data demonstrate that an insulin-inhibiting diet is safe and feasible in selected patients with advanced cancer. The extent of ketosis, but not calorie deficit or weight loss, correlated with stable disease or partial remission."
Nutrition. 2012 Oct;28(10):1028-35. doi: 10.1016/j.nut.2012.05.001. Epub 2012 Jul 26.
CONCLUSION: "Preliminary data demonstrate that an insulin-inhibiting diet is safe and feasible in selected patients with advanced cancer. The extent of ketosis, but not calorie deficit or weight loss, correlated with stable disease or partial remission."
Nutrition. 2012 Oct;28(10):1028-35. doi: 10.1016/j.nut.2012.05.001. Epub 2012 Jul 26.
fredag 24 juni 2016
Human Telomerase and Its Regulation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC120798/
ABSTRACT
"The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins. It is essential for maintaining the integrity and stability of linear eukaryotic genomes. Telomere length regulation and maintenance contribute to normal human cellular aging and human diseases. The synthesis of telomeres is mainly achieved by the cellular reverse transcriptase telomerase, an RNA-dependent DNA polymerase that adds telomeric DNA to telomeres. Expression of telomerase is usually required for cell immortalization and long-term tumor growth. In humans, telomerase activity is tightly regulated during development and oncogenesis. The modulation of telomerase activity may therefore have important implications in antiaging and anticancer therapy. This review describes the currently known components of the telomerase complex and attempts to provide an update on the molecular mechanisms of human telomerase regulation."
Cong Y-S, Wright WE, Shay JW. Human Telomerase and Its Regulation.Microbiology and Molecular Biology Reviews. 2002;66(3):407-425. doi:10.1128/MMBR.66.3.407-425.2002.
Cong Y-S, Wright WE, Shay JW. Human Telomerase and Its Regulation.Microbiology and Molecular Biology Reviews. 2002;66(3):407-425. doi:10.1128/MMBR.66.3.407-425.2002.
One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25738849
"This study confirms that a stabilized retinol (0.1%) formulation can significantly improve the signs of photoaging, and improvements in photodamage continue with prolonged use"
"This study confirms that a stabilized retinol (0.1%) formulation can significantly improve the signs of photoaging, and improvements in photodamage continue with prolonged use"
Randhawa M, Rossetti D, Leyden JJ, Fantasia J, Zeichner J, Cula GO, Southall M, Tucker-Samaras S.
J Drugs Dermatol. 2015 Mar;14(3):271-80.
- PMID:
- 25738849
onsdag 11 maj 2016
Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Tr... - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/27136347
CONCLUSIONS AND RELEVANCE:
"In nonobese adults, Calorie Restriction had some positive effects and no negative effects on health-related quality of life."
Martin CK, Bhapkar M, Pittas AG, et al. Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. JAMA Intern Med.2016;176(6):743-752. doi:10.1001/jamainternmed.2016.1189.
CONCLUSIONS AND RELEVANCE:
söndag 3 april 2016
Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
http://ajcn.nutrition.org/content/early/2016/02/10/ajcn.115.122317
Conclusion: "Egg or cholesterol intakes were not associated with increased CAD risk, even in ApoE4 carriers (i.e., in highly susceptible individuals)."
Am J Clin Nutr ajcn122317; First published online February 10, 2016. doi:10.3945/ajcn.115.122317
Conclusion: "Egg or cholesterol intakes were not associated with increased CAD risk, even in ApoE4 carriers (i.e., in highly susceptible individuals)."
Am J Clin Nutr ajcn122317; First published online February 10, 2016. doi:10.3945/ajcn.115.122317
torsdag 25 februari 2016
British Journal of Nutrition - Red meat from animals offered a grass diet increases plasma and platelet n-3 PUFA in healthy consumers - Cambridge Journals Online
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7948423&fulltextType=RA&fileId=S0007114510003090
Abstract
Abstract
"Red meat from grass-fed animals, compared with concentrate-fed animals, contains increased concentrations of long-chain (LC) n-3 PUFA. However, the effects of red meat consumption from grass-fed animals on consumer blood concentrations of LC n-3 PUFA are unknown. The aim of the present study was to compare the effects on plasma and platelet LC n-3 PUFA status of consuming red meat produced from either grass-fed animals or concentrate-fed animals. A randomised, double-blinded, dietary intervention study was carried out for 4 weeks on healthy subjects who replaced their habitual red meat intake with three portions per week of red meat (beef and lamb) from animals offered a finishing diet of either grass or concentrate (n 20 consumers). Plasma and platelet fatty acid composition, dietary intake, blood pressure, and serum lipids and lipoproteins were analysed at baseline and post-intervention. Dietary intakes of total n-3 PUFA, as well as plasma and platelet concentrations of LC n-3 PUFA, were significantly higher in those subjects who consumed red meat from grass-fed animals compared with those who consumed red meat from concentrate-fed animals (P < 0·05). No significant differences in concentrations of serum cholesterol, TAG or blood pressure were observed between groups. Consuming red meat from grass-fed animals compared with concentrate-fed animals as part of the habitual diet can significantly increase consumer plasma and platelet LC n-3 PUFA status. As a result, red meat from grass-fed animals may contribute to dietary intakes of LC n-3 PUFA in populations where red meat is habitually consumed."
British Journal of Nutrition / Volume 105 / Issue 01 / January 2011, pp 80-89DOI: http://dx.doi.org/10.1017/S0007114510003090 (About DOI), Published online: 01 September 2010
Composition differences between organic and conventional meat: a systematic literature review and meta-analysis
http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN115_06%2FS0007114515005073a.pdf&code=7cac44be9bbc705374f024857fd4885c
Abstract
"Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95 % CI 11, 35) % and 47 (95 % CI 10, 84) %
higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed."
Średnicka-Tober, D., Barański, M., Seal, C., Sanderson, R., Benbrook, C., Steinshamn, H., Gromadzka-Ostrowska, J., Rembiałkowska, E., Skwarło-Sońta, K., Eyre, M., Cozzi, G., Krogh Larsen, M., Jordon, T., Niggli, U., Sakowski, T., Calder, P.C., Burdge, G.C., Sotiraki, S., Stefanakis, A., Yolcu, H., Stergiadis, S., Chatzidimitriou, E., Butler, G., Stewart, G. and Leifert, C. (2016) ‘Composition differences between organic and conventional meat: a systematic literature review and meta-analysis’,British Journal of Nutrition, 115(6), pp. 994–1011. doi: 10.1017/S0007114515005073.
Abstract
"Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95 % CI 11, 35) % and 47 (95 % CI 10, 84) %
higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed."
Średnicka-Tober, D., Barański, M., Seal, C., Sanderson, R., Benbrook, C., Steinshamn, H., Gromadzka-Ostrowska, J., Rembiałkowska, E., Skwarło-Sońta, K., Eyre, M., Cozzi, G., Krogh Larsen, M., Jordon, T., Niggli, U., Sakowski, T., Calder, P.C., Burdge, G.C., Sotiraki, S., Stefanakis, A., Yolcu, H., Stergiadis, S., Chatzidimitriou, E., Butler, G., Stewart, G. and Leifert, C. (2016) ‘Composition differences between organic and conventional meat: a systematic literature review and meta-analysis’,British Journal of Nutrition, 115(6), pp. 994–1011. doi: 10.1017/S0007114515005073.
måndag 22 februari 2016
Health effects of vegetarian and vegan diets. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/16441942
"Studies of cancer have not shown clear differences in cancer rates between vegetarians and non-vegetarians."
Key TJ, Appleby PN, Rosell MS.
Proc Nutr Soc. 2006 Feb;65(1):35-41. Review.
PMID: 16441942
"Studies of cancer have not shown clear differences in cancer rates between vegetarians and non-vegetarians."
Key TJ, Appleby PN, Rosell MS.
Proc Nutr Soc. 2006 Feb;65(1):35-41. Review.
PMID: 16441942
Vegetarian diets, chronic diseases and longevity. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/19166134
Very probably, an ample consumption of fruits and vegetables and not the exclusion of meat make vegetarians healthful.
Very probably, an ample consumption of fruits and vegetables and not the exclusion of meat make vegetarians healthful.
Ginter E.
Bratisl Lek Listy. 2008;109(10):463-6. Review.
PMID: 19166134
Bratisl Lek Listy. 2008;109(10):463-6. Review.
PMID: 19166134
tisdag 16 februari 2016
Metabolic characteristics of keto-adapted ultra-endurance runners - Metabolism - Clinical and Experimental
http://www.metabolismjournal.com/article/S0026-0495(15)00334-0/abstract?elsca1=etoc&elsca2=email&elsca3=0026-0495_201603_65_3_&elsca4=Genetics%7CEndocrinology%7CDiabetes%7CCardiology
Background
Many successful ultra-endurance athletes have switched from a high-carbohydrate to a low-carbohydrate diet, but they have not previously been studied to determine the extent of metabolic adaptations.
Conclusion
Compared to highly trained ultra-endurance athletes consuming an HC diet, long-term keto-adaptation results in extraordinarily high rates of fat oxidation, whereas muscle glycogen utilization and repletion patterns during and after a 3 hour run are similar.
DOI: http://dx.doi.org/10.1016/j.metabol.2015.10.028
DOI: http://dx.doi.org/10.1016/j.metabol.2015.10.028
måndag 18 januari 2016
Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with ozone therapy | Rowen | African Journal of Infectious Diseases
http://www.ajol.info/index.php/ajid/article/view/126773
Background: Ebola Virus Disease (EVD) has ravaged three countries in West Africa. The mortality rate is extremely high, and it is perceived not only as threat to all of Africa but to the entire world. There is no known treatment to date other than administration of convalescent blood or experimental monoclonal antibodies, which both often fail. Ozone therapy (OT) has been in clinical use for decades and has been found to have physiological effects, which should directly inactivate the virus itself, as well as modulate its damaging effects. We present the scientific background and the possibility of ozone therapy as a cure or prevention for EVD in five consecutive patients.
Materials and Methods: Ozone therapy administration by a combination of direct intravenous gas administration, rectal gas administration and ozonized water was administered to three patients with known acute EVD, one with apparent acute infection, and one case of extremely high risk. Treatment was carried out for up to ten days despite fast total remission of symptoms. Vitamin C and glutathione supporting supplements were administered.
Results: Four symptomatic patients, three with test positive EVD confirmation and one (who suffered Ebola contaminated needle stick contamination three days earlier) without lab confirmation all remitted symptoms within 2-4 days and fully recovered. All four ill cases had an immediate recovery course upon initiation of therapy. The single case of non-symptomatic high-risk exposure treated preventively did not develop symptoms.
Conclusion: Ebola virus may have a very narrow window of redox infectivity capacity, which can be easily exploited with OT. OT may be a useful modality in EVD and other viral diseases and should be immediately studied to save lives that might otherwise be lost.
Rowen et al., Afr. J. Infect. Dis. (2016) 10 (1): 49– 54
http://dx.doi.org/10.4314/ajid.v10i1.10
Background: Ebola Virus Disease (EVD) has ravaged three countries in West Africa. The mortality rate is extremely high, and it is perceived not only as threat to all of Africa but to the entire world. There is no known treatment to date other than administration of convalescent blood or experimental monoclonal antibodies, which both often fail. Ozone therapy (OT) has been in clinical use for decades and has been found to have physiological effects, which should directly inactivate the virus itself, as well as modulate its damaging effects. We present the scientific background and the possibility of ozone therapy as a cure or prevention for EVD in five consecutive patients.
Materials and Methods: Ozone therapy administration by a combination of direct intravenous gas administration, rectal gas administration and ozonized water was administered to three patients with known acute EVD, one with apparent acute infection, and one case of extremely high risk. Treatment was carried out for up to ten days despite fast total remission of symptoms. Vitamin C and glutathione supporting supplements were administered.
Results: Four symptomatic patients, three with test positive EVD confirmation and one (who suffered Ebola contaminated needle stick contamination three days earlier) without lab confirmation all remitted symptoms within 2-4 days and fully recovered. All four ill cases had an immediate recovery course upon initiation of therapy. The single case of non-symptomatic high-risk exposure treated preventively did not develop symptoms.
Conclusion: Ebola virus may have a very narrow window of redox infectivity capacity, which can be easily exploited with OT. OT may be a useful modality in EVD and other viral diseases and should be immediately studied to save lives that might otherwise be lost.
Rowen et al., Afr. J. Infect. Dis. (2016) 10 (1): 49– 54
http://dx.doi.org/10.4314/ajid.v10i1.10
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