http://www.ncbi.nlm.nih.gov/pubmed/24704972
måndag 13 april 2015
fredag 10 april 2015
The association of fatty acids with prostate cancer risk. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/11398173
Conclusions:
Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, alpha-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer.
Conclusions:
Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, alpha-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer.
Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/20580779
Our results suggested that incorporation of almonds into a healthy diet has beneficial effects on adiposity, glycemic control, and the lipid profile, thereby potentially decreasing the risk for cardiovascular disease in patients with type 2 diabetes mellitus
Our results suggested that incorporation of almonds into a healthy diet has beneficial effects on adiposity, glycemic control, and the lipid profile, thereby potentially decreasing the risk for cardiovascular disease in patients with type 2 diabetes mellitus
Kakaoflavanoler - Hälsopåstående - Livsmedelsverket
http://eur-lex.europa.eu/legal-content/SV/TXT/PDF/?uri=OJ:JOL_2015_088_R_0003&from=SV
Påstående
Kakaoflavanoler hjälper
till att hålla blodkärlen
elastiska, vilket bidrar till
en normal blodcirkulation
(*****) (******)
Villkor för användning av påståendet
Konsumenterna ska upplysas om att den gynnsamma effekten
uppnås vid ett dagligt intag av 200 mg kakaoflavanoler.
Påståendet får bara användas för kakaodrycker (med kakaopulver)
eller för mörk choklad som tillhandahåller ett dagligt
intag på minst 200 mg kakaoflavanoler med en polymeriseringsgrad
på 1–10 (*****).
Påståendet får bara användas för kapslar eller tabletter innehållande
kakaoextrakt med hög halt flavanoler vilka tillhandahåller
ett dagligt intag på minst 200 mg kakaoflavanoler
med en polymeriseringsgrad på 1–10 (******).
(*****) Godkänt den 24 september 2013, användningen begränsad till Barry Callebaut Belgium NV, Aalstersestraat 122, 9280 Lebbeke-Wieze, Belgien, under en femårsperiod.
(******) Godkänt den 21 april 2015, användningen begränsad till Barry Callebaut Belgium NV, Aalstersestraat 122, 9280 Lebbeke-Wieze, Belgien, under en femårsperiod.”
Påstående
Kakaoflavanoler hjälper
till att hålla blodkärlen
elastiska, vilket bidrar till
en normal blodcirkulation
(*****) (******)
Villkor för användning av påståendet
Konsumenterna ska upplysas om att den gynnsamma effekten
uppnås vid ett dagligt intag av 200 mg kakaoflavanoler.
Påståendet får bara användas för kakaodrycker (med kakaopulver)
eller för mörk choklad som tillhandahåller ett dagligt
intag på minst 200 mg kakaoflavanoler med en polymeriseringsgrad
på 1–10 (*****).
Påståendet får bara användas för kapslar eller tabletter innehållande
kakaoextrakt med hög halt flavanoler vilka tillhandahåller
ett dagligt intag på minst 200 mg kakaoflavanoler
med en polymeriseringsgrad på 1–10 (******).
(*****) Godkänt den 24 september 2013, användningen begränsad till Barry Callebaut Belgium NV, Aalstersestraat 122, 9280 Lebbeke-Wieze, Belgien, under en femårsperiod.
(******) Godkänt den 21 april 2015, användningen begränsad till Barry Callebaut Belgium NV, Aalstersestraat 122, 9280 Lebbeke-Wieze, Belgien, under en femårsperiod.”
torsdag 9 april 2015
BMC Cancer | Full text | Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines
http://www.biomedcentral.com/1471-2407/6/13
Abstract
Background
Mediterranean societies, with diets rich in vitamin E isoforms, have a lower risk for colon cancer than those of northern Europe and the Americas. Vitamin E rich diets may neutralize free radicals generated by fecal bacteria in the gut and prevent DNA damage, but signal transduction activities can occur independent of the antioxidant function. The term vitamin E represents eight structurally related compounds, each differing in their potency and mechanisms of chemoprevention. The RRR-γ-tocopherol isoform is found primarily in the US diet, while RRR-α-tocopherol is highest in the plasma.
Methods
The effectiveness of RRR-α- and RRR-γ-tocopherol at inhibiting cell growth and inducing apoptosis in colon cancer cell lines with varying molecular characteristics (SW480, HCT-15, HCT-116 and HT-29) and primary colon cells (CCD-112CoN, nontransformed normal phenotype) was studied. Colon cells were treated with and without RRR-α- or RRR-γ-tocopherol using varying tocopherol concentrations and time intervals. Cell proliferation and apoptosis were measured using the trypan blue assay, annexin V staining, DNA laddering and caspase activation.
Results
Treatment with RRR-γ-tocopherol resulted in significant cell death for all cancer cell lines tested, while RRR-α-tocopherol did not. Further, RRR-γ-tocopherol treatment showed no cytotoxicity to normal colon cells CCD-112CoN at the highest concentration and time point tested. RRR-γ-tocopherol treatment resulted in cleavage of PARP, caspase 3, 7, and 8, but not caspase 9. Differences in the percentage cell death and apoptosis were observed in different cell lines suggesting that molecular differences in these cell lines may influence the ability of RRR-γ-tocopherol to induce cell death.
Conclusion
This is the first study to demonstrate that multiple colon cancer cell lines containing varying genetic alterations will under go growth reduction and apoptosis in the presence of RRR-γ-tocopherol without damage to normal colon cells. The amount growth reduction was dependent upon the molecular signatures of the cell lines. Since RRR-γ-tocopherol is effective at inhibition of cell proliferation at both physiological and pharmacological concentrations dietary RRR-γ-tocopherol may be chemopreventive, while pharmacological concentrations of RRR-γ-tocopherol may aid chemotherapy without toxic effects to normal cells demonstrated by most chemotherapeutic agents.
måndag 6 april 2015
Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25701700/
CONCLUSIONS:
In a cross-over trial of subjects with suspected nonceliac gluten sensitivity, the severity of overall symptoms increased significantly during 1 week of intake of small amounts of gluten, compared with placebo.
söndag 5 april 2015
Nutrition & Metabolism | Full text | How do high glycemic load diets influence coronary heart disease?
http://www.nutritionandmetabolism.com/content/12/1/6
Abstract
Background
Diet has a significant relationship with the risk of coronary heart disease (CHD). Traditionally the effect of diet on CHD was measured with the biomarker for low-density lipoprotein (LDL) cholesterol. However, LDL is not the only or even the most important biomarker for CHD risk. A suitably integrated view of the mechanism by which diet influences the detailed CHD pathogenetic pathways is therefore needed in order to better understand CHD risk factors and help with better holistic CHD prevention and treatment decisions.
Methods
A systematic review of the existing literature was conducted. From this an integrated CHD pathogenetic pathway system was constructed. CHD biomarkers, which are found on these pathways, are the only measurable data to link diet with these CHD pathways. They were thus used to simplify the link between diet and the CHD mechanism. Data were systematically analysed from 294 cohort studies of CHD biomarkers constituting 1 187 350 patients.
Results and discussion
The resulting integrated analysis provides insight into the higher-order interactions underlying CHD and high-glycemic load (HGL) diets. A novel “connection graph” illustrates the measurable relationship between HGL diets and the relative risks attributed to the important CHD serological biomarkers.
The “connection graph” vividly shows that HGL diets not only influence the lipid and metabolic biomarkers, but also the inflammation, coagulation and vascular function biomarkers in an important way.
Conclusion
A focus primarily on the low density lipoprotein cholesterol biomarker for CHD risk has led to the traditional guidelines of CHD dietary recommendations. This has however inadvertently led to HGL diets. The influence of HGL diets on the other CHD biomarkers is not always fully appreciated. Thus, new diets or other interventions which address the full integrated CHD impact, as shown in this paper, are required.
onsdag 1 april 2015
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