The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
Dietary Carbohydrates Impair Healthspan and Promote Mortality
Ravichandran, Meenakshi et al.
Cell Metabolism , Volume 26 , Issue 4 , 585 - 587
