http://news.berkeley.edu/2015/09/17/what-the-inuit-can-tell-us-about-omega-3-fats-and-paleo-diets/
The traditional diet of Greenland natives — the Inuit — is held up as an example of how high levels of omega-3 fatty acids can counterbalance the bad health effects of a high-fat diet, but a new study hints that what’s true for the Inuit may not be true for everyone else.
tisdag 22 september 2015
måndag 21 september 2015
PLOS ONE: High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133286
Abstract
Physical activity improves the regulation of glucose homeostasis in both type 2 diabetes (T2D) patients and healthy individuals, but the effect on pancreatic β cell function is unknown. We investigated glycaemic control, pancreatic function and total fat mass before and after 8 weeks of low volume high intensity interval training (HIIT) on cycle ergometer in T2D patients and matched healthy control individuals. Study design/method: Elderly (56 yrs±2), non-active T2D patients (n = 10) and matched (52 yrs±2) healthy controls (CON) (n = 13) exercised 3 times (10×60 sec. HIIT) a week over an 8 week period on a cycle ergometer. Participants underwent a 2-hour oral glucose tolerance test (OGTT). On a separate day, resting blood pressure measurement was conducted followed by an incremental maximal oxygen uptake (
O2max) cycle ergometer test. Finally, a whole body dual X-ray absorptiometry (DXA) was performed. After 8 weeks of training, the same measurements were performed. Results: in the T2D-group, glycaemic control as determined by average fasting venous glucose concentration (p = 0.01), end point 2-hour OGTT (p = 0.04) and glycosylated haemoglobin (p = 0.04) were significantly reduced. Pancreatic homeostasis as determined by homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA β cell function (HOMA-%β) were both significantly ameliorated (p = 0.03 and p = 0.03, respectively). Whole body insulin sensitivity as determined by the disposition index (DI) was significantly increased (p = 0.03). During OGTT, the glucose continuum was significantly reduced at -15 (p = 0.03), 30 (p = 0.03) and 120 min (p = 0.03) and at -10 (p = 0.003) and 0 min (p = 0.003) with an additional improvement (p = 0.03) of its 1stphase (30 min) area under curve (AUC). Significant abdominal fat mass losses were seen in both groups (T2D: p = 0.004 and CON: p = 0.02) corresponding to a percentage change of -17.84%±5.02 and -9.66%±3.07, respectively. Conclusion: these results demonstrate that HIIT improves overall glycaemic control and pancreatic β cell function in T2D patients. Additionally, both groups experienced abdominal fat mass losses. These findings demonstrate that HIIT is a health beneficial exercise strategy in T2D patients.
O2max) cycle ergometer test. Finally, a whole body dual X-ray absorptiometry (DXA) was performed. After 8 weeks of training, the same measurements were performed. Results: in the T2D-group, glycaemic control as determined by average fasting venous glucose concentration (p = 0.01), end point 2-hour OGTT (p = 0.04) and glycosylated haemoglobin (p = 0.04) were significantly reduced. Pancreatic homeostasis as determined by homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA β cell function (HOMA-%β) were both significantly ameliorated (p = 0.03 and p = 0.03, respectively). Whole body insulin sensitivity as determined by the disposition index (DI) was significantly increased (p = 0.03). During OGTT, the glucose continuum was significantly reduced at -15 (p = 0.03), 30 (p = 0.03) and 120 min (p = 0.03) and at -10 (p = 0.003) and 0 min (p = 0.003) with an additional improvement (p = 0.03) of its 1stphase (30 min) area under curve (AUC). Significant abdominal fat mass losses were seen in both groups (T2D: p = 0.004 and CON: p = 0.02) corresponding to a percentage change of -17.84%±5.02 and -9.66%±3.07, respectively. Conclusion: these results demonstrate that HIIT improves overall glycaemic control and pancreatic β cell function in T2D patients. Additionally, both groups experienced abdominal fat mass losses. These findings demonstrate that HIIT is a health beneficial exercise strategy in T2D patients.
söndag 20 september 2015
The Power of Protein at Breakfast for School-Aged Children
https://www.uaex.edu/publications/PDF/FSFCS86.pdf
Easy Ways to Add More Protein
to Breakfast
It is easy to incorporate more protein into
children’s breakfasts. Here are a couple of ideas for
including more highquality protein in breakfast:
- Eggs: Make a breakfast burrito or a breakfast
sandwich with scrambled eggs for a portable
breakfast. Eggs can also be served with toast
or prepared in an omelet with lowfat cheese
and vegetables. - Dairy: Adding Greek yogurt to fruit smoothies is
a way to add 1015 grams of protein to a child’s
breakfast. Eating lowfat regular or Greek
yogurt by itself or mixed with cereal and fruit is
another way to add protein to breakfast. - Breakfast meats: Add lean breakfast meats
such as turkey bacon, turkey sausage or
Canadian bacon to breakfast.
fredag 28 augusti 2015
Antioxidants prevent health-promoting effects of physical exercise in humans - PNAS
http://www.pnas.org/content/106/21/8665.long
Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.
Svenska via Google translate:
Tillskott med antioxidanter kan hindra dessa hälsofrämjande effekter av träning på människor.
Biological Sciences - Medical Sciences:
Michael Ristow, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C. Ronald Kahn, and Matthias Blüher
Antioxidants prevent health-promoting effects of physical exercise in humans
PNAS 2009 106 (21) 8665-8670; published ahead of print May 11, 2009, doi:10.1073/pnas.0903485106
Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.
Svenska via Google translate:
Tillskott med antioxidanter kan hindra dessa hälsofrämjande effekter av träning på människor.
Biological Sciences - Medical Sciences:
Michael Ristow, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C. Ronald Kahn, and Matthias Blüher
Antioxidants prevent health-promoting effects of physical exercise in humans
PNAS 2009 106 (21) 8665-8670; published ahead of print May 11, 2009, doi:10.1073/pnas.0903485106
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/26109578
Results:
...
Dietary cholesterol was not statistically significantly associated with any coronary artery disease...
ischemic stroke or hemorrhagic stroke.
...
Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis.
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ.
Am J Clin Nutr. 2015 Aug;102(2):276-94. doi: 10.3945/ajcn.114.100305. Epub 2015 Jun 24.
PMID: 26109578
Results:
...
Dietary cholesterol was not statistically significantly associated with any coronary artery disease...
ischemic stroke or hemorrhagic stroke.
...
Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis.
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ.
Am J Clin Nutr. 2015 Aug;102(2):276-94. doi: 10.3945/ajcn.114.100305. Epub 2015 Jun 24.
PMID: 26109578
måndag 17 augusti 2015
PLOS ONE: Man the Fat Hunter: The Demise of Homo erectus and the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr) Levant
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028689
Abstract
The worldwide association of H. erectus with elephants is well documented and so is the preference of humans for fat as a source of energy. We show that rather than a matter of preference, H. erectus in the Levant was dependent on both elephants and fat for his survival. The disappearance of elephants from the Levant some 400 kyr ago coincides with the appearance of a new and innovative local cultural complex – the Levantine Acheulo-Yabrudian and, as is evident from teeth recently found in the Acheulo-Yabrudian 400-200 kyr site of Qesem Cave, the replacement of H. erectus by a new hominin. We employ a bio-energetic model to present a hypothesis that the disappearance of the elephants, which created a need to hunt an increased number of smaller and faster animals while maintaining an adequate fat content in the diet, was the evolutionary drive behind the emergence of the lighter, more agile, and cognitively capable hominins. Qesem Cave thus provides a rare opportunity to study the mechanisms that underlie the emergence of our post-erectus ancestors, the fat hunters.
Citation: Ben-Dor M, Gopher A, Hershkovitz I, Barkai R (2011)
Man the Fat Hunter: The Demise of Homo erectus and
the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr)
Levant. PLoS ONE 6(12): e28689. doi:10.1371/journal.pone.0028689
Man the Fat Hunter: The Demise of Homo erectus and
the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr)
Levant. PLoS ONE 6(12): e28689. doi:10.1371/journal.pone.0028689
måndag 10 augusti 2015
PEER-REVIEWED PAPER SUGGESTS GENETICALLY ENGINEERED SOY (GMO) PRODUCES EXCESS FORMALDEHYDE AND DISRUPTS NATURAL PLANT METABOLISM | International Center for Integrative Systems
http://www.integrativesystems.org/systems-biology-of-gmos/
Ayyadurai, V.A.S. and Deonikar, P. (2015) Do GMOs
Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria? Systems
Biology May Provide Answers. Agricultural Sciences, 6,
630-662. doi:10.4236/as.2015.67062.
Eat more salt and live longer (especially if you have had a cardiovascular event)
04:00 - Funnel plost - Publication Bias
08:20 - Causation vs
Association Studies
09:50 - journal NEJM
back in 1972
there
is a bit of concern about the low salt diet. You can lower blood pressure okay
nobody's disputing that but there's a price to pay, you're going to raise a
renin and aldosterone levels fairly
substantially. So while you may lower your blood pressure you may actually put
yourself at higher risk have coronary artery disease.
10:39 - Intrasalt
Study (the main reason for recent advice to lower salt comsumption)
17:00 - Salt and
Mortality.
If
you eat less salt, you are more likely to die
As
you take a high-salt diet your mortality, goes down
As you take more more salt, cardiovascular disease goes down
20:20 - People with
high blood pressure, the people the guideline tells to eat less salt.
Cardiovascular event rate for people as they
take more more salt their cardiovascular
evnt rate goes down and down
23:20 - Journal of
the American Medical Association
They
took 3,685 people and they followed them for seven point nine year
You
had 23 times increase in your cardiac event ray when you take a low-salt diet,
it looks pretty bad
25:10 - Another
cochran review
there
was one group that it looked like urs actually very harmful to follow a
low-salt diet back group was the cardiac patients, so the people with heart
failure the ones I you all tell to eat a low salt diet, they seem to do much
worse, much worse than everybody else
25:30 - Potential
Harm From Too Little Salt Intake (The National Academies of Sciences)
Especially
for those people with heart failure you want to be very very careful because
the low salt diet might be extremely harmful to you okay it's not only not good
for you but it might be actually very harmful to you and that everything else
was that there was a really enough
Evidence
indicates that low sodium intake may lead to risk of adverse health effects
among those with mid- to late-stage heart failure who are receiving aggressive
treatment for their disease
27:10 - Tradeoffs
for low sodium intake
Blood
Pressure - 3.85 % Decrease (best-case scenario)
Renin (hormone) + 24.3 % Increase
Aldosterone (hormone) + 24.5 % Increase
Adrenaline (hormone) + 9 % Increase
28:20 - The modern
treatment for atherosclerosis
Renin - Renin
inhibitors are used to treat hypertension
Aldosterone - spironolactone, ARBs & ACE Inhibitors are used to treat high levels
of Aldosterone
Adrenaline - is blocked with Beta Blocker
tisdag 28 juli 2015
Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25346455
CONCLUSION:
The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.
CONCLUSION:
The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.
torsdag 23 juli 2015
A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488064/
Leslie MA, Cohen DJA, Liddle DM, Robinson LE, Ma DWL. A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. Lipids in Health and Disease. 2015;14:53. doi:10.1186/s12944-.
fredag 26 juni 2015
3 studies about Vitamin C and Cancer
Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences of the United States of America. 1976;73(10):3685-3689.
PMCID: PMC431183
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC431183/
Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer.Proceedings of the National Academy of Sciences of the United States of America. 1978;75(9):4538-4542.
PMCID: PMC336151
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC336151/
Cabanillas F. Vitamin C and cancer: what can we conclude--1,609 patients and
33 years later? P R Health Sci J. 2010 Sep;29(3):215-7. Review. PubMed
PMID: 20799507.
http://www.ncbi.nlm.nih.gov/pubmed/20799507
tisdag 16 juni 2015
Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113605
Abstract
Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids (SFA) predict greater risk for developing type-2 diabetes and heart disease. These observations suggest a disconnect between dietary saturated fat and plasma SFA, but few controlled feeding studies have specifically examined how varying saturated fat intake across a broad range affects circulating SFA levels. Sixteen adults with metabolic syndrome (age 44.9±9.9 yr, BMI 37.9±6.3 kg/m2) were fed six 3-wk diets that progressively increased carbohydrate (from 47 to 346 g/day) with concomitant decreases in total and saturated fat. Despite a distinct increase in saturated fat intake from baseline to the low-carbohydrate diet (46 to 84 g/day), and then a gradual decrease in saturated fat to 32 g/day at the highest carbohydrate phase, there were no significant changes in the proportion of total SFA in any plasma lipid fractions. Whereas plasma saturated fat remained relatively stable, the proportion of palmitoleic acid in plasma triglyceride and cholesteryl ester was significantly and uniformly reduced as carbohydrate intake decreased, and then gradually increased as dietary carbohydrate was re-introduced. The results show that dietary and plasma saturated fat are not related, and that increasing dietary carbohydrate across a range of intakes promotes incremental increases in plasma palmitoleic acid, a biomarker consistently associated with adverse health outcomes.
Citation: Volk BM, Kunces LJ, Freidenreich DJ, Kupchak BR, Saenz C, Artistizabal JC, et al. (2014) Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome. PLoS ONE 9(11): e113605. doi:10.1371/journal.pone.0113605
Abstract
Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids (SFA) predict greater risk for developing type-2 diabetes and heart disease. These observations suggest a disconnect between dietary saturated fat and plasma SFA, but few controlled feeding studies have specifically examined how varying saturated fat intake across a broad range affects circulating SFA levels. Sixteen adults with metabolic syndrome (age 44.9±9.9 yr, BMI 37.9±6.3 kg/m2) were fed six 3-wk diets that progressively increased carbohydrate (from 47 to 346 g/day) with concomitant decreases in total and saturated fat. Despite a distinct increase in saturated fat intake from baseline to the low-carbohydrate diet (46 to 84 g/day), and then a gradual decrease in saturated fat to 32 g/day at the highest carbohydrate phase, there were no significant changes in the proportion of total SFA in any plasma lipid fractions. Whereas plasma saturated fat remained relatively stable, the proportion of palmitoleic acid in plasma triglyceride and cholesteryl ester was significantly and uniformly reduced as carbohydrate intake decreased, and then gradually increased as dietary carbohydrate was re-introduced. The results show that dietary and plasma saturated fat are not related, and that increasing dietary carbohydrate across a range of intakes promotes incremental increases in plasma palmitoleic acid, a biomarker consistently associated with adverse health outcomes.
Citation: Volk BM, Kunces LJ, Freidenreich DJ, Kupchak BR, Saenz C, Artistizabal JC, et al. (2014) Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome. PLoS ONE 9(11): e113605. doi:10.1371/journal.pone.0113605
fredag 12 juni 2015
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25458341
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R.
Diabetes Res Clin Pract. 2015 Jan;107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. Epub 2014 Oct 8.
PMID: 25458341
http://www.ncbi.nlm.nih.gov/pubmed/25458341
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R.
Diabetes Res Clin Pract. 2015 Jan;107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. Epub 2014 Oct 8.
PMID: 25458341
http://www.ncbi.nlm.nih.gov/pubmed/25458341
onsdag 3 juni 2015
Antitumor activity of astaxanthin and its mode of action. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/10798217
Antitumor activity of astaxanthin and its mode of action.
Jyonouchi H, Sun S, Iijima K, Gross MD.
Nutr Cancer. 2000;36(1):59-65.
PMID: 10798217
Jyonouchi H, Sun S, Iijima K, Gross MD.
Nutr Cancer. 2000;36(1):59-65.
PMID: 10798217
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