måndag 25 mars 2019

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study | The BMJ

https://www.bmj.com/content/364/bmj.l962


Conclusion: Findings suggest that an offspring’s risk of autism spectrum disorder increases following prenatal exposure to ambient pesticides within 2000 m of their mother’s residence during pregnancy, compared with offspring of women from the same agricultural region without such exposure. Infant exposure could further increase risks for autism spectrum disorder with comorbid intellectual disability.


von Ehrenstein, O. S., Ling, C., Cui, X., Cockburn, M., Park, A. S., Yu, F., Wu, J. & Ritz, B. (2019). Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. BMJ, 364. 

fredag 15 mars 2019

No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/14578137/


"In several epidemiological studies, high intakes of fruits and vegetables have been associated with a lower incidence of cancer. Theoretically, intake of antioxidants by consumption of fruits and vegetables should protect against reactive oxygen species and decrease the formation of oxidative DNA damage."

...

"Our results show that after 24 days of complete depletion of fruits and vegetables, or daily ingestion of 600 g of fruit and vegetables, or the corresponding amount of vitamins and minerals, the level of oxidative DNA damage was unchanged."


Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1016-22.

Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778858/


Conclusions: Ecological data indicate an increase in meat intake in Asian countries; however, our pooled analysis did not provide evidence of a higher risk of mortality for total meat intake and provided evidence of an inverse association with red meat, poultry, and fish/seafood. Red meat intake was inversely associated with CVD (cardiovascular disease) mortality in men and with cancer mortality in women in Asian countries.


Lee JE, McLerran DF, Rolland B, et al. Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies. Am J Clin Nutr. 2013;98(4):1032-41.

onsdag 6 mars 2019

Infection control for norovirus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624335/


"Ready-to-eat foods (such as leafy greens) and foods handled after cooking are the most frequently identified products associated with outbreaks"

"Leafy vegetables, fruits, and shellfish, all of which are commonly consumed raw or undercooked, are the food commodities most commonly reported as the cause of foodborne norovirus outbreaks"

"Norwalk virus seeded into ground water for at least 61 days was still able to infect human volunteers"


Barclay L, Park GW, Vega E, et al. Infection control for norovirus. Clin Microbiol Infect. 2014;20(8):731-40.

Human norovirus transmission and evolution in a changing world. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/27211790


"the globalization of the food industry, which enables large norovirus outbreaks to occur on an international scale."

"studies have shown that approximately 7% of foodborne outbreaks of noroviruses are part of an international event with a common source. Globally, noroviruses rank among the top causes of foodborne disease"


de Graaf, M., van Beek, J. & Koopmans, M. P. (2016). Human norovirus transmission and evolution in a changing world. Nat Rev Microbiol, 14(7), ss. 421-433. DOI:10.1038/nrmicro.2016.48

fredag 22 februari 2019

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes: Cell Metabolism

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30355-2



"In five separate studies of 39 high-performance athletes, we show how this unique metabolic state improves physical endurance by altering fuel competition for oxidative respiration."



DOI: https://doi.org/10.1016/j.cmet.2016.07.010

Ketone Bodies as a Therapeutic Strategy for Heart Failure: Biophysical Journal

https://www.cell.com/biophysj/pdf/S0006-3495(18)31300-6.pdf


"Taken together, we conclude that the shift to ketone body oxidation in heart failure is adaptive and that strategies to increase myocardial ketone body delivery show promise for the treatment of heart failure."


DOI: https://doi.org/10.1016/j.bpj.2018.11.035

torsdag 7 februari 2019

Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study

https://journals.plos.org/plosone/article/file?id=10.1371%2Fjournal.pone.0088278&type=printable&fbclid=IwAR2UexAtdXJ7KMoygzSRzBbrblv5RNUPnX8g89KZTZqXQIq_k48PWujzR4w


"Moreover, our results showed that a vegetarian diet is associated with poorer health (higher incidences of cancer, allergies, and mental health disorders), a higher need for health care, and poorer quality of life."


Burkert NT, Muckenhuber J, Großscha¨dl F, Ra´sky E´, Freidl W (2014) Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study. PLoS ONE 9(2): e88278. doi:10.1371/journal.pone.0088278

måndag 19 november 2018

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial | The BMJ

https://www.bmj.com/content/363/bmj.k4583

Conclusions: Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.


Ebbeling, C. B., Feldman, H. A., Klein, G. L., Wong, J. M. W., Bielak, L., Steltz, S. K., Luoto, P. K., Wolfe, R. R., Wong, W. W. & Ludwig, D. S. (2018). Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. BMJ, 363.

lördag 10 november 2018

Reduced Salt Intake for Heart Failure: A Systematic Review | Cardiology | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2712563?guestAccessKey=0a69688c-1460-4f16-9415-a5cedc82b8d2&utm_source=silverchair&utm_campaign=jama_network&utm_content=weekly_highlights&cmp=1&utm_medium=email


"Conclusions and Relevance  Limited evidence of clinical improvement was available among outpatients who reduced dietary salt intake, and evidence was inconclusive for inpatients. Overall, a paucity of robust high-quality evidence to support or refute current guidance was available. This review suggests that well-designed, adequately powered studies are needed to reduce uncertainty about the use of this intervention."

Al-Mohammad  A, Mant  J.  The diagnosis and management of chronic heart failure: review following the publication of the NICE guidelines.  Heart. 2011;97(5):411-416. doi:10.1136/hrt.2010.214999




tisdag 9 oktober 2018

Effects of household washing on bacterial load and removal of Escherichia coli from lettuce and "ready-to-eat" salads. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/29188050


"Even after washing, the lettuce contained high levels of bacteria that in a high dose and under certain circumstances may constitute a health risk."



Uhlig, E., Olsson,
C., He, J., Stark, T., Sadowska, Z., Molin, G., Ahrne, S., Alsanius, B. &
Hakansson, A. (2017). Effects of household washing on bacterial load and
removal of Escherichia coli from lettuce and "ready-to-eat" salads. Food Sci Nutr, 5(6), ss. 1215-1220. DOI:10.1002/fsn3.514

måndag 1 oktober 2018

Frontiers | The Hurdle Approach–A Holistic Concept for Controlling Food Safety Risks Associated With Pathogenic Bacterial Contamination of Leafy Green Vegetables. A Review | Microbiology

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01965/full



"A concerning trend in recent years is disease outbreaks caused by various leafy vegetable crops and one of the most important foodborne pathogens in this context is Shiga toxin-producing Escherichia coli (STEC)"


Mogren, L.,
Windstam, S., Boqvist, S., Vågsholm, I., Söderqvist, K., Rosberg, A. K.,
LindГ©n, J., Mulaosmanovic, E., Karlsson, M., Uhlig, E., HГҐkansson, Г. s.
& Alsanius, B. (2018). The Hurdle Approach–A Holistic Concept for
Controlling Food Safety Risks Associated With Pathogenic Bacterial
Contamination of Leafy Green Vegetables. A Review. Frontiers in Microbiology, 9(1965). DOI:10.3389/fmicb.2018.01965

lördag 11 augusti 2018

Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis | Demyelinating Disorders | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2695647?guestAccessKey=b3c0e1a2-d206-4df0-8bce-2d938a392652



"These findings suggest inhibitors of VEGF-B–FLT-1 signaling or agonists of TGF-α–ErbB1 signaling may represent promising anti-inflammatory and neuroprotective therapies for MS and possibly other neurodegenerative diseases. Diets that promote anti-inflammatory pathways could be a noninvasive approach to treating brain inflammation"



Hampton T. Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis. JAMA. 2018;320(5):429–430. doi:10.1001/jama.2017.12863

torsdag 15 mars 2018

Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort | The BMJ

http://www.bmj.com/content/360/bmj.k322



"Conclusions In this large prospective study, a 10%
increase in the proportion of ultra-processed foods in the diet was
associated with a significant increase of greater than 10% in risks of
overall and breast cancer (Fiolet et al. 2018)."



Fiolet, T., Srour,
B., Sellem, L., Kesse-Guyot, E., Alles, B., Mejean, C., Deschasaux, M.,
Fassier, P., Latino-Martel, P., Beslay, M., Hercberg, S., Lavalette, C.,
Monteiro, C. A., Julia, C. & Touvier, M. (2018). Consumption of
ultra-processed foods and cancer risk: results from NutriNet-Sante prospective
cohort. BMJ, 360, s. k322. DOI:10.1136/bmj.k322