lördag 10 november 2018

Reduced Salt Intake for Heart Failure: A Systematic Review | Cardiology | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2712563?guestAccessKey=0a69688c-1460-4f16-9415-a5cedc82b8d2&utm_source=silverchair&utm_campaign=jama_network&utm_content=weekly_highlights&cmp=1&utm_medium=email


"Conclusions and Relevance  Limited evidence of clinical improvement was available among outpatients who reduced dietary salt intake, and evidence was inconclusive for inpatients. Overall, a paucity of robust high-quality evidence to support or refute current guidance was available. This review suggests that well-designed, adequately powered studies are needed to reduce uncertainty about the use of this intervention."

Al-Mohammad  A, Mant  J.  The diagnosis and management of chronic heart failure: review following the publication of the NICE guidelines.  Heart. 2011;97(5):411-416. doi:10.1136/hrt.2010.214999




tisdag 9 oktober 2018

Effects of household washing on bacterial load and removal of Escherichia coli from lettuce and "ready-to-eat" salads. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/29188050


"Even after washing, the lettuce contained high levels of bacteria that in a high dose and under certain circumstances may constitute a health risk."



Uhlig, E., Olsson,
C., He, J., Stark, T., Sadowska, Z., Molin, G., Ahrne, S., Alsanius, B. &
Hakansson, A. (2017). Effects of household washing on bacterial load and
removal of Escherichia coli from lettuce and "ready-to-eat" salads. Food Sci Nutr, 5(6), ss. 1215-1220. DOI:10.1002/fsn3.514

måndag 1 oktober 2018

Frontiers | The Hurdle Approach–A Holistic Concept for Controlling Food Safety Risks Associated With Pathogenic Bacterial Contamination of Leafy Green Vegetables. A Review | Microbiology

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01965/full



"A concerning trend in recent years is disease outbreaks caused by various leafy vegetable crops and one of the most important foodborne pathogens in this context is Shiga toxin-producing Escherichia coli (STEC)"


Mogren, L.,
Windstam, S., Boqvist, S., Vågsholm, I., Söderqvist, K., Rosberg, A. K.,
LindГ©n, J., Mulaosmanovic, E., Karlsson, M., Uhlig, E., HГҐkansson, Г. s.
& Alsanius, B. (2018). The Hurdle Approach–A Holistic Concept for
Controlling Food Safety Risks Associated With Pathogenic Bacterial
Contamination of Leafy Green Vegetables. A Review. Frontiers in Microbiology, 9(1965). DOI:10.3389/fmicb.2018.01965

lördag 11 augusti 2018

Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis | Demyelinating Disorders | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2695647?guestAccessKey=b3c0e1a2-d206-4df0-8bce-2d938a392652



"These findings suggest inhibitors of VEGF-B–FLT-1 signaling or agonists of TGF-α–ErbB1 signaling may represent promising anti-inflammatory and neuroprotective therapies for MS and possibly other neurodegenerative diseases. Diets that promote anti-inflammatory pathways could be a noninvasive approach to treating brain inflammation"



Hampton T. Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis. JAMA. 2018;320(5):429–430. doi:10.1001/jama.2017.12863

torsdag 15 mars 2018

Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort | The BMJ

http://www.bmj.com/content/360/bmj.k322



"Conclusions In this large prospective study, a 10%
increase in the proportion of ultra-processed foods in the diet was
associated with a significant increase of greater than 10% in risks of
overall and breast cancer (Fiolet et al. 2018)."



Fiolet, T., Srour,
B., Sellem, L., Kesse-Guyot, E., Alles, B., Mejean, C., Deschasaux, M.,
Fassier, P., Latino-Martel, P., Beslay, M., Hercberg, S., Lavalette, C.,
Monteiro, C. A., Julia, C. & Touvier, M. (2018). Consumption of
ultra-processed foods and cancer risk: results from NutriNet-Sante prospective
cohort. BMJ, 360, s. k322. DOI:10.1136/bmj.k322



torsdag 1 mars 2018

High-Fat and Ketogenic Diets in Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438106/


"In summary, there are strong epidemiologic data showing that malnutrition is a common symptom of amyotrophic lateral sclerosis both in humans and in mice and may contribute to disease progression. There is also epidemiologic evidence that increased dietary fat and cholesterol intake might reduce the risk of amyotrophic lateral sclerosis and the rate disease progression. Finally, data from animal studies strongly suggest that increasing dietary intake of fat ameliorates disease progression (Paganoni & Wills
2013)."



Paganoni, S. & Wills, A. M. (2013). High-fat and ketogenic diets in amyotrophic lateral sclerosis. J Child Neurol, 28(8), ss. 989-992.
DOI:10.1177/0883073813488669



tisdag 27 februari 2018

Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pubmed/27868154


"In both epilepsy and ALS, there are defects in glucose uptake and reduced tricarboxylic acid
(TCA) cycling, at least in part due to reduced amounts of C4 TCA cycle intermediates. In addition there are impairments in glycolysis in ALS. A reduction in glucose uptake can be addressed by providing the brain with alternative fuels, such as ketones or medium-chain triglycerides (Tefera et al. 2017)."


Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis. - PubMed - NCBI: Neurochem Res. 2017 Jun;42(6):1610-1620. doi: 10.1007/s11064-016-2106-7. Epub 2016 Nov 21.

Can ketogenic diet slow progression of ALS? - The Lancet Neurology

http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(06)70462-8.pdf


"For the first time, researchers have shown that diet can alter the
progression of amyotrophic lateral sclerosis (ALS) in a mouse model of
the disease (Siva 2006)."


Can ketogenic diet slow progression of ALS?
Siva, Nayanah
The Lancet Neurology , Volume 5 , Issue 6 , 476



onsdag 17 januari 2018

Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions | British Journal of Sports Medicine

http://bjsm.bmj.com/content/51/15/1111



"Coronary artery disease pathogenesis and treatment urgently requires a paradigm shift. Despite popular belief among doctors and the public, the conceptual model of dietary saturated fat clogging a pipe is just plain wrong."




Malhotra ARedberg RFMeier P
Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions


Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence - Colantuoni - 2002 - Obesity - Wiley Online Library

http://onlinelibrary.wiley.com/doi/10.1038/oby.2002.66/abstract;jsessionid=53655E300DCC6F52F425701CBE72C85E.f02t04


Discussion: Repeated, excessive intake of sugar created a state in which an opioid antagonist caused behavioral and neurochemical signs of opioid withdrawal. The indices of anxiety and DA/ACh imbalance were qualitatively similar to withdrawal from morphine or nicotine, suggesting that the rats had become sugar-dependent.


Colantuoni, C., Rada, P., McCarthy, J., Patten, C., Avena, N. M., Chadeayne, A. and Hoebel, B. G. (2002), Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence. Obesity Research, 10: 478–488. doi:10.1038/oby.2002.66

tisdag 21 november 2017

Dietary Carbohydrates Impair Healthspan and Promote Mortality: Cell Metabolism

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30562-4


The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.


Dietary Carbohydrates Impair Healthspan and Promote Mortality

Ravichandran, Meenakshi et al.
Cell Metabolism , Volume 26 , Issue 4 , 585 - 587

måndag 18 september 2017

Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917888/



"Our results showed that a vegetarian diet is associated with poorer health (higher incidences of cancer, allergies, and mental health disorders), a higher need for health care, and poorer quality of life. Therefore, public health programs are needed in order to reduce the health risk due to nutritional factors."


Burkert NT, Muckenhuber J, Großschädl F, Rásky É, Freidl W.
Nutrition and Health – The Association between Eating Behavior and Various
Health Parameters: A Matched Sample Study. Gorlova OY, ed. 
PLoS ONE. 2014;9(2):e88278. doi:10.1371/journal.pone.0088278.

tisdag 12 september 2017

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity - Gastroenterology

http://www.gastrojournal.org/article/S0016-5085(17)35685-8/fulltext


"Conclusions
Short-term (9 days) isocaloric fructose restriction decreased liver fat, VAT, and DNL, and improved insulin kinetics in children with obesity. These findings support efforts to reduce sugar consumption. ClinicalTrials.gov Number: NCT01200043."


Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity

Schwarz, Jean-Marc et al.
Gastroenterology , Volume 153 , Issue 3 , 743 - 752

torsdag 31 augusti 2017

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study - The Lancet

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext




"Interpretation

High carbohydrate intake was associated with higher risk of total mortality, whereas total fat and individual types of fat were related to lower total mortality. Total fat and types of fat were not associated with cardiovascular disease, myocardial infarction, or cardiovascular disease mortality, whereas saturated fat had an inverse association with stroke. Global dietary guidelines should be reconsidered in light of these findings."

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study - The Lancet, DOI: http://dx.doi.org/10.1016/S0140-6736(17)32252-3