tag:blogger.com,1999:blog-4868547518639893162024-03-06T02:50:19.348+01:00Ät Rätt:s Ät dig FriskVetenskapen om vad ska man äta för att hålla sig frisk!
The science on what to eat to stay healthy!Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comBlogger309125tag:blogger.com,1999:blog-486854751863989316.post-88477546029703843462022-04-05T18:52:00.001+02:002022-04-05T18:52:33.121+02:00The relationship between peripheral blood mononuclear cells telomere length and diet – unexpected effect of red meat – PMC<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/</a></p>
<p> </p>
<div id="__sec4" class="sec sec-last">
<h3 id="__sec4title">Conclusions</h3>
<p id="Par5" class="p p-first-last">Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.</p>
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<p> </p>
<p>Kasielski M, Eusebio MO, Pietruczuk M, Nowak D. The relationship between peripheral blood mononuclear cells telomere length and diet – unexpected effect of red meat. <i>Nutr J</i>. 2016;15(1):68. Published 2016 Jul 14. doi:10.1186/s12937-016-0189-2</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-60293242952915578412022-02-11T07:52:00.001+01:002022-02-11T07:52:50.703+01:00Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness<p><a href="https://pubmed.ncbi.nlm.nih.gov/35113901/">https://pubmed.ncbi.nlm.nih.gov/35113901/</a></p>
<p>”<strong class="sub-title">Conclusions:</strong> Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.”</p>
<p>Dror AA, Morozov N, Daoud A, Namir Y, Yakir O, Shachar Y, Lifshitz M, Segal E, Fisher L, Mizrachi M, Eisenbach N, Rayan D, Gruber M, Bashkin A, Kaykov E, Barhoum M, Edelstein M, Sela E. Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PLoS One. 2022 Feb 3;17(2):e0263069. doi: 10.1371/journal.pone.0263069. PMID: 35113901; PMCID: PMC8812897.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-78500970375472284942021-12-18T08:52:00.001+01:002021-12-18T08:52:21.409+01:00Intermittent Fasting and Obesity-Related Health Outcomes<p><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787246">https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787246</a></p>
<p><strong>Meaning</strong> This review suggests that intermittent fasting may have a beneficial role in improving anthropometric and cardiometabolic outcomes, especially for adults with overweight or obesity.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-23983731248738942892021-12-14T07:52:00.001+01:002021-12-14T07:52:22.624+01:00Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies<p><a href="https://pubmed.ncbi.nlm.nih.gov/34882024/">https://pubmed.ncbi.nlm.nih.gov/34882024/</a></p>
<p>”We found a significant direct association between vitamin D deficiency and elevated risk of COVID-19 in-hospital mortality. Moreover, each unit increment in serum vitamin D levels was associated to significant reduction in risk of COVID-19 mortality.”</p>
<p>Ebrahimzadeh A, Mohseni S, Narimani B, Ebrahimzadeh A, Kazemi S, Keshavarz F, Yaghoubi MJ, Milajerdi A. Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr. 2021 Dec 9:1-11. doi: 10.1080/10408398.2021.2012419. Epub ahead of print. PMID: 34882024.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-67288270882160134332021-12-09T07:52:00.001+01:002021-12-09T07:52:54.521+01:00Riboflavin (vitamin B-2) and health<p><a href="https://pubmed.ncbi.nlm.nih.gov/12791609/">https://pubmed.ncbi.nlm.nih.gov/12791609/</a></p>
<p>”Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets. Meat and fish are also good sources of riboflavin”</p>
<p>”Biochemical signs of depletion arise within only a few days of dietary deprivation.”</p>
<p>”There is reasonably good evidence that poor riboflavin status interferes with iron handling and contributes to the etiology of anemia when iron intakes are low. Various mechanisms for this have been proposed, including effects on the gastrointestinal tract that might compromise the handling of other nutrients.”</p>
<p>Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003 Jun;77(6):1352-60. doi: 10.1093/ajcn/77.6.1352. PMID: 12791609.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-13639460572111978972021-11-30T07:52:00.001+01:002021-11-30T07:52:29.572+01:00Role of Vitamins in Neurodegenerative Diseases: A Review<p><a href="https://pubmed.ncbi.nlm.nih.gov/34802410/">https://pubmed.ncbi.nlm.nih.gov/34802410/</a></p>
<p>”<strong class="sub-title">Background:</strong> Vitamins are the micronutrients required for boosting the immune system and managing any future infection. Vitamins are involved in neurogenesis, a defense mechanism working in neurons, metabolic reactions, neuronal survival, and neuronal transmission. Their deficiency leads to abnormal functions in the brain like oxidative stress, mitochondrial dysfunction, accumulation of proteins (synuclein, Aβ plaques), neurodegeneration, and excitotoxicity.”</p>
<p>”<strong class="sub-title">Conclusion:</strong> The deficiency of vitamins in the body causes various neurological disorders like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and depression. We have discussed the role of vitamins in neurological disorders and the normal human body. Depression is linked to a deficiency of vitamin-C and vitamin B. In the case of Alzheimer’s disease, there is a lack of vitamin-B1, B12, and vitamin-A, which results in Aβ-plaques. Similarly, in Parkinson’s disease, vitamin-D deficiency leads to a decrease in the level of dopamine, and imbalance in vitamin D leads to accumulation of synuclein. In MS, Vitamin-C and Vitamin-D deficiency causes demyelination of neurons. In Huntington’s disease, vitamin- C deficiency decreases the antioxidant level, enhances oxidative stress, and disrupts the glucose cycle. Vitamin B5 deficiency in Huntington’s disease disrupts the synthesis of acetylcholine and hormones in the brain.”</p>
<p>Kumar RR, Singh L, Thakur A, Singh S, Kumar B. Role of Vitamins in Neurodegenerative Diseases: A Review. CNS Neurol Disord Drug Targets. 2021 Nov 19. doi: 10.2174/1871527320666211119122150. Epub ahead of print. PMID: 34802410.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-7211671344798283322021-11-24T07:19:00.001+01:002021-11-24T07:19:10.116+01:00Vitamin A supplementation and serum Th1- and Th2-associated cytokine response in women<p><a href="https://pubmed.ncbi.nlm.nih.gov/24024773/">https://pubmed.ncbi.nlm.nih.gov/24024773/</a></p>
<p>”<strong class="sub-title">Conclusions:</strong> Decline in serum concentrations of IL-1β and IL-1β/IL-4 ratio in obese women suggests that vitamin A is capable of regulating the immune system and possibly reducing the risk of autoimmune disease in this group.”</p>
<p>Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. Vitamin A supplementation and serum Th1- and Th2-associated cytokine response in women. J Am Coll Nutr. 2013;32(4):280-5. doi: 10.1080/07315724.2013.816616. PMID: 24024773.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-17192104422868557412021-11-10T07:20:00.001+01:002021-11-10T07:20:54.055+01:00The Role of Vitamin A in Wound Healing<p><a href="https://pubmed.ncbi.nlm.nih.gov/31389093/">https://pubmed.ncbi.nlm.nih.gov/31389093/</a></p>
<h2>Abstract</h2>
<p>Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro-vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol-binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator-activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re-epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti-inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.</p>
<p>Polcz ME, Barbul A. The Role of Vitamin A in Wound Healing. Nutr Clin Pract. 2019 Oct;34(5):695-700. doi: 10.1002/ncp.10376. Epub 2019 Aug 7. PMID: 31389093.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-85742705439876722072021-10-28T21:52:00.001+02:002021-10-28T21:52:43.759+02:00Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541329/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541329/</a></p>
<p> </p>
<p>Conclusion:</p>
<p>Diet-induced obesity increased the levels of viral entry proteins in the lungs, providing a mechanism whereby SARS-CoV-2 infectivity can be enhanced in obese individuals. Conversely, by maintaining low levels of ACE2 and TMPRSS2 and by exerting an anti-inflammatory effect, the KD can potentially attenuate the severity of infection and migration of SARS-CoV-2 to other ACE2-expressing tissues.</p>
<p> </p>
<p>Da Eira D, Jani S, Ceddia RB. Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues. <i>Nutrients</i>. 2021;13(10):3357. Published 2021 Sep 25. doi:10.3390/nu13103357</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-79290284509432290942021-09-20T21:52:00.003+02:002021-09-20T21:52:39.333+02:00A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19 – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/34395368/">A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19 – PubMed</a></p>
<p> </p>
<p>”The machine-driven framework we developed repeatedly pointed to elevated blood glucose as a key facilitator in the progression of COVID-19. Indeed, when we systematically retraced the steps of the SARS-CoV-2 infection, we found evidence linking elevated glucose to each major step of the life-cycle of the virus, progression of the disease, and presentation of symptoms. Specifically, elevations of glucose provide ideal conditions for the virus to evade and weaken the first level of the immune defense system in the lungs, gain access to deep alveolar cells, bind to the ACE2 receptor and enter the pulmonary cells, accelerate replication of the virus within cells increasing cell death and inducing an pulmonary inflammatory response, which overwhelms an already weakened innate immune system to trigger an avalanche of systemic infections, inflammation and cell damage, a cytokine storm and thrombotic events. We tested the feasibility of the hypothesis by manually reviewing the literature referenced by the machine-generated synthesis, reconstructing atomistically the virus at the surface of the pulmonary airways, and performing quantitative computational modeling of the effects of glucose levels on the infection process. We conclude that elevation in glucose levels can facilitate the progression of the disease through multiple mechanisms and can explain much of the differences in disease severity seen across the population.”</p>
<p> </p>
<div class="citation-text">Logette E, Lorin C, Favreau C, Oshurko E, Coggan JS, Casalegno F, Sy MF, Monney C, Bertschy M, Delattre E, Fonta PA, Krepl J, Schmidt S, Keller D, Kerrien S, Scantamburlo E, Kaufmann AK, Markram H. A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19. Front Public Health. 2021 Jul 28;9:695139. doi: 10.3389/fpubh.2021.695139. PMID: 34395368; PMCID: PMC8356061.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-69676838683308590122021-09-20T21:52:00.001+02:002021-09-20T21:52:38.363+02:00Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/34151773/">Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice – PubMed</a></p>
<p> </p>
<p>”Aged mCoV-A59-infected mice have increased mortality and higher systemic inflammation in the heart, adipose tissue, and hypothalamus, including neutrophilia and loss of γδ T cells in lungs. Activation of ketogenesis in aged mice expands tissue protective γδ T cells, deactivates the NLRP3 inflammasome, and decreases pathogenic monocytes in lungs of infected aged mice. These data establish harnessing of the ketogenic immunometabolic checkpoint as a potential treatment against coronavirus infection in the aged.”</p>
<p> </p>
<div class="citation-text">Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. Elife. 2021 Jun 21;10:e66522. doi: 10.7554/eLife.66522. PMID: 34151773; PMCID: PMC8245129.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-55414972143607152392021-09-20T20:52:00.009+02:002021-09-20T20:52:44.515+02:00Clinical efficacy of eucaloric ketogenic nutrition in the COVID-19 cytokine storm: A retrospective analysis of mortality and intensive care unit admission – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/33895559/">Clinical efficacy of eucaloric ketogenic nutrition in the COVID-19 cytokine storm: A retrospective analysis of mortality and intensive care unit admission – PubMed</a></p>
<p> </p>
<p><strong class="sub-title">”Conclusions:</strong> These results show a possible therapeutic role of an EKD in the clinical management of COVID-19. Currently, a prospective controlled randomized trial is running to confirm these preliminary data.”</p>
<p> </p>
<div class="citation-text">Sukkar SG, Cogorno L, Pisciotta L, Pasta A, Vena A, Gradaschi R, Dentone C, Guiddo E, Martino E, Beltramini S, Donini LM, Carmisciano L, Sormani MP, Bassetti M; GECOVID Study Group. Clinical efficacy of eucaloric ketogenic nutrition in the COVID-19 cytokine storm: A retrospective analysis of mortality and intensive care unit admission. Nutrition. 2021 Sep;89:111236. doi: 10.1016/j.nut.2021.111236. Epub 2021 Mar 7. PMID: 33895559; PMCID: PMC7937042.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-71582543650489762042021-09-20T20:52:00.007+02:002021-09-20T20:52:43.372+02:00Can ketone bodies inactivate coronavirus spike protein? The potential of biocidal agents against SARS-CoV-2 – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/33857328/">Can ketone bodies inactivate coronavirus spike protein? The potential of biocidal agents against SARS-CoV-2 – PubMed</a></p>
<p> </p>
<p>”Also, a new prophylactic and therapeutic measure against SARS-CoV-2 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein.”</p>
<p> </p>
<div class="citation-text">Shaheen A. Can ketone bodies inactivate coronavirus spike protein? The potential of biocidal agents against SARS-CoV-2. Bioessays. 2021 Jun;43(6):e2000312. doi: 10.1002/bies.202000312. Epub 2021 Apr 15. PMID: 33857328; PMCID: PMC8250295.</div>
<p> </p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-3530900475821074862021-09-20T20:52:00.005+02:002021-09-20T20:52:42.071+02:00Ketogenic Diet as a Preventive and Supportive Care for COVID-19 Patients – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/33804603/">Ketogenic Diet as a Preventive and Supportive Care for COVID-19 Patients – PubMed</a></p>
<p> </p>
<p>”The association of obesity and COVID-19 prognosis may be related to many different factors, such as chronic systemic inflammation, the predisposition to severe respiratory conditions and viral infections. The ketogenic diet is an approach that can be extremely effective in reducing body weight and visceral fat in the short term, preserving the lean mass and reducing systemic inflammation. Therefore, it is a precious preventive measure for severely obese people and may be considered as an adjuvant therapy for patients with respiratory compromise.”</p>
<p> </p>
<div class="citation-text">Gangitano E, Tozzi R, Gandini O, Watanabe M, Basciani S, Mariani S, Lenzi A, Gnessi L, Lubrano C. Ketogenic Diet as a Preventive and Supportive Care for COVID-19 Patients. Nutrients. 2021 Mar 20;13(3):1004. doi: 10.3390/nu13031004. PMID: 33804603; PMCID: PMC8003632.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-47428411285252492832021-09-20T20:52:00.003+02:002021-09-20T20:52:40.830+02:00Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/33236006/">Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model – PubMed</a></p>
<p> </p>
<p><strong class="sub-title">”Highlights:</strong> – Natural MHV-A59 mouse coronavirus infection mimics COVID-19 in elderly.- Aged infected mice have systemic inflammation and inflammasome activation.- Murine beta coronavirus (mCoV) infection results in loss of pulmonary γδ T cells.- Ketones protect aged mice from infection by reducing inflammation.</p>
<p><strong class="sub-title">etoc blurb:</strong> Elderly have the greatest risk of death from COVID-19. Here, Ryu et al report an aging mouse model of coronavirus infection that recapitulates clinical hallmarks of COVID-19 seen in elderly. The increased severity of infection in aged animals involved increased inflammasome activation and loss of γδ T cells that was corrected by ketogenic diet.”</p>
<p> </p>
<p> </p>
<div class="citation-text">Ryu S, Shchukina I, Youm YH, Qing H, Hilliard BK, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna KM, Horvath TL, Dietrich MO, Artyomov MN, Wang A, Dixit VD. Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv [Preprint]. 2020 Sep 12:2020.09.11.294363. doi: 10.1101/2020.09.11.294363. Update in: Elife. 2021 Jun 21;10: PMID: 33236006; PMCID: PMC7685240.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-78045324928247967142021-09-20T20:52:00.001+02:002021-09-20T20:52:39.706+02:00[Obesity, inflammation and COVID-19: preventive interest of ketogenic diet?] – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/34397376/">[Obesity, inflammation and COVID-19: preventive interest of ketogenic diet?] – PubMed</a></p>
<p> </p>
<p>Numerous studies suggest that obesity could be defined as key to the onset of severe forms of this emerging disease. Indeed, SARS-CoV2 infects the host by binding to ACE2 receptors present on the surface of the cells and causes excessive secretion of pro-inflammatory cytokines including IL-1, IL-6 and TNF-α, which lead to developing acute respiratory distress syndrome (ARDS). It therefore seems essential to make up effective preventive strategies to protect this part of the population from the risk of developing a severe form of COVID-19. The ketogenic diet, which is low in sugars and high in fat, has interesting properties, both in the fight against obesity but also against severe infections.</p>
<p> </p>
<div class="citation-text">Charlot A, Boumiza R, Roux M, Zoll J. Obésité, inflammation et COVID-19 : intérêt préventif de l’alimentation cétogène ? [Obesity, inflammation and COVID-19: preventive interest of ketogenic diet?]. Biol Aujourdhui. 2021;215(1-2):63-72. French. doi: 10.1051/jbio/2021004. Epub 2021 Aug 16. PMID: 34397376.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-68781019899120941092021-09-14T15:52:00.001+02:002021-09-14T15:52:55.593+02:00Påverkar vitaminer och metaboliter risken för ö-cellsautoantikroppar och utveckling av diabetes? 2021<p><a rel="noreferrer noopener" href="https://www.teddy.lu.se/resultat-fran-teddy/alla-forskningsartiklar-indelade-i-amnen/autoantikroppar/paverkar-vitaminer-och-metaboliter-risken-o-cellsautoantikroppar-och-utveckling-av-diabetes-2021" target="_blank">https://www.teddy.lu.se/resultat-fran-teddy/alla-forskningsartiklar-indelade-i-amnen/autoantikroppar/paverkar-vitaminer-och-metaboliter-risken-o-cellsautoantikroppar-och-utveckling-av-diabetes-2021</a></p>
<p>Frågeställningen i studien var om ämnesomsättningsprodukter så kallade metaboliter (aminosyror, fettsyror med mera) och vitaminer (vitamin C och D) i plasma var förändrade före det att en första autoantikropp utvecklades.</p>
<ul>
<li>Resultatet från studien visar att barn som fick IAA som första autoantikropp vid ett års ålder hade låga nivåer av vitamin C och kolesterol före det att IAA utvecklades.</li>
<li>Lite äldre barn som fick GADA som första autoantikropp visade sig ha låga nivåer av sfingomyelin, en fosfolipid som finns i mjölkfett och som är mycket viktig för immunsystemet men också för hjärnans celler, centrala nervsystemet samt den neurologiska utvecklingen.</li>
<li>De barn som utvecklade antingen IAA eller GADA som första autoantikropp och hade låga nivåer av vitamin D, hade störst risk att få en andra autoantikropp och att utveckla diabetes på kort tid. Barn med GADA som första autoantikropp hade också låga plasmanivåer av diglycerider, lysofosfatidylkolin, triglycerider och alanin, vilket ökade deras risk att utveckla en andra autoantikropp och diabetes.</li>
</ul>
<p>Studien visar att låga nivåer av både vitamin D och C ökade risken att utveckla en första autoantikropp. Andra biomarkörer hade också låga nivåer före uppkomsten av den första autoantikroppen. </p>
<p>TEDDY har kunnat påvisa att vanliga enterovirusinfektioner kan trigga en första autoantikropp hos vissa men inte alla barn. Låga nivåer av vitamin D och C samt andra metaboliter tycks kunna bidra till att en virusinfektion utvecklar diabetes hos barn.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-90019063159085797202021-08-25T20:52:00.003+02:002021-08-25T20:52:27.280+02:00Adenosine and Ketogenic Treatments – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/32954218/">Adenosine and Ketogenic Treatments – PubMed</a></p>
<p> </p>
<p>”In addition, KD treatment elevates extracellular adenosine and tissue adenosine content in brain.”</p>
<p> </p>
<div class="citation-text">Ruskin DN, Kawamura M, Masino SA. Adenosine and Ketogenic Treatments. J Caffeine Adenosine Res. 2020 Sep 1;10(3):104-109. doi: 10.1089/caff.2020.0011. Epub 2020 Sep 16. PMID: 32954218; PMCID: PMC7499891.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-70912162914339726882021-08-25T20:52:00.001+02:002021-08-25T20:52:25.790+02:00Adenosine and Autism – Recent Research and a New Perspective | IntechOpen<p>Källa: <a href="https://www.intechopen.com/chapters/18064">Adenosine and Autism – Recent Research and a New Perspective | IntechOpen</a></p>
<p>”Specifically, we propose that persons with autism can benefit from increased levels of adenosine, a powerful inhibitory neuromodulator and the core molecule of adenosine triphosphate (ATP).”</p>
<p> </p>
<p>Susan A. Masino, Julia Svedova, Masahito Kawamura, Jr., Francis D. DiMario, Jr. and Inge-Marie Eigsti (August 17th 2011). Adenosine and Autism – Recent Research and a New Perspective, Autism – A Neurodevelopmental Journey from Genes to Behaviour, Valsamma Eapen, IntechOpen, DOI: 10.5772/18957. Available from: <a href="https://www.intechopen.com/chapters/18064" rel="nofollow">https://www.intechopen.com/chapters/18064</a></p>
<p> </p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-66569602492696992262021-08-25T18:53:00.001+02:002021-08-25T18:53:30.546+02:00Ketogenic diet with medium-chain triglycerides restores skeletal muscle function and pathology in a rat model of Duchenne muscular dystrophy – PubMed<p>Källa: <a href="https://pubmed.ncbi.nlm.nih.gov/34416029/">Ketogenic diet with medium-chain triglycerides restores skeletal muscle function and pathology in a rat model of Duchenne muscular dystrophy – PubMed</a></p>
<p>”We found that the MCT-KD significantly increased muscle strength and fiber diameter in these rats. The MCT-KD significantly suppressed the key features of DMD, namely, muscle necrosis, inflammation, and subsequent fibrosis.”</p>
<p> </p>
<div class="citation-text">Fujikura Y, Sugihara H, Hatakeyama M, Oishi K, Yamanouchi K. Ketogenic diet with medium-chain triglycerides restores skeletal muscle function and pathology in a rat model of Duchenne muscular dystrophy. FASEB J. 2021 Sep;35(9):e21861. doi: 10.1096/fj.202100629R. PMID: 34416029.</div>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-80249013131723851202021-08-11T16:52:00.001+02:002021-08-11T16:52:46.448+02:00Intake of Ultraprocessed Foods Among US YouthsHealth Concerns and Opportunities for Research and Policy<p><a href="https://jamanetwork.com/journals/jama/article-abstract/2782880">https://jamanetwork.com/journals/jama/article-abstract/2782880</a></p>
<p>”The potential implications for future health are significant. Childhood is a critical period for biological development and the establishment of dietary behaviors. Recent systematic reviews and meta-analyses have found that higher intake of ultraprocessed foods is associated with a range of adverse health outcomes in adults and with overweight or obesity in children”</p>
<p>Meyer KA, Taillie LS. Intake of Ultraprocessed Foods Among US Youths: Health Concerns and Opportunities for Research and Policy. <em>JAMA.</em>2021;326(6):485–487. doi:10.1001/jama.2021.9845</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-86762769411589263702021-06-29T07:56:00.001+02:002021-06-29T07:56:39.211+02:00Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial<p><a href="https://pubmed.ncbi.nlm.nih.gov/31700717/">https://pubmed.ncbi.nlm.nih.gov/31700717/</a></p>
<p>Conclusion This study shows the short-term beneficial effects of carbohydrate-restricted diet on serum BDNF and executive function in those individuals characterized with MetS. We have shown that the addition of exercise can further improve neuroprotection and cognitive function beyond the results of diet alone.</p>
<p>Gyorkos A, Baker MH, Miutz LN, Lown DA, Jones MA, Houghton-Rahrig LD. Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial. Cureus. 2019 Sep 9;11(9):e5604. doi: 10.7759/cureus.5604. PMID: 31700717; PMCID: PMC6822553.</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-13719884639561998102021-06-06T09:56:00.001+02:002021-06-06T09:56:47.494+02:00Induction of ketosis as a potential therapeutic option to limit hyperglycemia and prevent cytokine storm in COVID-19<p>Källa: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416786/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416786</a></p>
<p>”Abstract</p>
<p>The severe form of coronavirus disease 19 (COVID-19) is characterized by cytokine storm syndrome (CSS) and disseminated intravascular coagulation (DIC). Diabetes, obesity, and hypertension have, as minor common denominators, chronic low-grade inflammation and high plasma myeloperoxidase levels, which could be linked to pulmonary phagocytic hyperactivation and CSS. The hyperactivation of M1 macrophages with a proinflammatory phenotype, which is linked to aerobic glycolysis, leads to the recruitment of monocytes, neutrophils, and platelets from circulating blood and plays a crucial role in thrombo-inflammation (as recently demonstrated in COVID-19) through the formation of neutrophil extracellular traps and monocyte-platelet aggregates, which could be responsible for DIC. The modulation of glucose availability for activated M1 macrophages by means of a eucaloric ketogenic diet (EKD) could represent a possible metabolic tool for reducing adenosine triphosphate production from aerobic glycolysis in the M1 macrophage phenotype during the exudative phase. This approach could reduce the overproduction of cytokines and, consequently, the accumulation of neutrophils, monocytes, and platelets from the blood. Second, an EKD could be advantageous for the metabolism of anti-inflammatory M2 macrophages because these cells predominantly express oxidative phosphorylation enzymes and are best fed by the oxidation of fatty acids in the mitochondria. An EKD could guarantee the availability of free fatty acids, which are an optimal fuel supply for these cells. Third, an EKD, which could reduce high lactate formation by macrophages due to glycolysis, could favor the production of interferon type I, which are inhibited by excessive lactate production. From a practical point of view, the hypothesis, in addition to being proven in clinical studies, must obviously take into account the contraindications of an EKD, particularly type 1 or 2 diabetes treated with drugs that can cause hypoglycemia, to avoid the risk for side effects of the diet.”</p>
<p>Sukkar SG, Bassetti M. Induction of ketosis as a potential therapeutic option to limit hyperglycemia and prevent cytokine storm in COVID-19. Nutrition. 2020;79-80:110967. doi:10.1016/j.nut.2020.110967</p>
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Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-37353355747612676602021-05-31T07:38:00.000+02:002021-05-31T07:38:30.951+02:00Vitamin D and Lung Outcomes in Elderly COVID-19 Patients<p> <a href="https://pubmed.ncbi.nlm.nih.gov/33668240/">https://pubmed.ncbi.nlm.nih.gov/33668240/</a></p><p><br /></p><p>”<b style="-webkit-text-size-adjust: 100%; box-sizing: inherit; caret-color: rgb(33, 33, 33); color: #212121; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px;"> Conclusions:</b><span style="-webkit-text-size-adjust: 100%; background-color: white; caret-color: rgb(33, 33, 33); color: #212121; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px;"> This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.</span>”</p><p><br /></p><p><span style="-webkit-text-size-adjust: 100%; background-color: white; caret-color: rgb(33, 33, 33); color: #212121; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px;">Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.</span></p>Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.comtag:blogger.com,1999:blog-486854751863989316.post-65839661195357898552021-05-27T19:47:00.004+02:002021-05-27T19:48:03.165+02:00Intermittent fasting in mice effective at promoting long term memory retention: Intermittent fasting in mice demonstrably more effective at promoting long term memory retention -- ScienceDaily<p><a href="https://www.sciencedaily.com/releases/2021/05/210524215527.htm">https://www.sciencedaily.com/releases/2021/05/210524215527.htm</a></p><p> "Over the course of three months, the mice in the IF group demonstrated
improved long-term memory retention compared to the other groups. When
the brains of these mice were studied, it was apparent that the Klotho
gene was upregulated, and neurogenesis increased compared to those that
were on the CR diet." </p><p>King's College London. (2021, May 24). Intermittent fasting in mice
effective at promoting long term memory retention: Intermittent fasting
in mice demonstrably more effective at promoting long term memory
retention. <em>ScienceDaily</em>. Retrieved May 27, 2021 from www.sciencedaily.com/releases/2021/05/210524215527.htm</p>Henrik Dahlinhttp://www.blogger.com/profile/07727145889098155906noreply@blogger.com