A drug that can stop tumors from growing -- ScienceDaily

https://www.sciencedaily.com/releases/2021/04/210407174307.htm

 

Summary:

Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion.

 

 

 University of Colorado Anschutz Medical Campus. (2021, April 7). A drug that can stop tumors from growing. ScienceDaily. Retrieved May 16, 2021 from www.sciencedaily.com/releases/2021/04/210407174307.htm

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation

 https://pubmed.ncbi.nlm.nih.gov/21673053/

” Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet.”

” Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression”

Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res. 2011 Jul 1;71(13):4484-93. doi: 10.1158/0008-5472.CAN-10-3973. Epub 2011 Jun 14. PMID: 21673053.

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? - PubMed

https://pubmed.ncbi.nlm.nih.gov/21885251/

 

Abstract

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.

 

Seyfried TN, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26. doi: 10.1016/j.eplepsyres.2011.06.017. Epub 2011 Aug 31. PMID: 21885251.

 

Red Meat Intake and Cardiometabolic and Cancer Outcomes | Annals of Internal Medicine | American College of Physicians

https://annals.org/aim/fullarticle/2752326/effect-lower-versus-higher-red-meat-intake-cardiometabolic-cancer-outcomes?searchresult=1


Conclusion:
Low- to very-low-certainty evidence suggests that diets restricted in red meat may have little or no effect on major cardiometabolic outcomes and cancer mortality and incidence.


Zeraatkar D, Johnston BC, Bartoszko J, et al. Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials. Ann Intern Med. 2019; [Epub ahead of print 1 October 2019]. doi: 10.7326/M19-0622

No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/14578137/


"In several epidemiological studies, high intakes of fruits and vegetables have been associated with a lower incidence of cancer. Theoretically, intake of antioxidants by consumption of fruits and vegetables should protect against reactive oxygen species and decrease the formation of oxidative DNA damage."

...

"Our results show that after 24 days of complete depletion of fruits and vegetables, or daily ingestion of 600 g of fruit and vegetables, or the corresponding amount of vitamins and minerals, the level of oxidative DNA damage was unchanged."


Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1016-22.

Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort | The BMJ

http://www.bmj.com/content/360/bmj.k322

"Conclusions In this large prospective study, a 10%
increase in the proportion of ultra-processed foods in the diet was
associated with a significant increase of greater than 10% in risks of
overall and breast cancer (Fiolet et al. 2018)."

Fiolet, T., Srour,
B., Sellem, L., Kesse-Guyot, E., Alles, B., Mejean, C., Deschasaux, M.,
Fassier, P., Latino-Martel, P., Beslay, M., Hercberg, S., Lavalette, C.,
Monteiro, C. A., Julia, C. & Touvier, M. (2018). Consumption of
ultra-processed foods and cancer risk: results from NutriNet-Sante prospective
cohort. BMJ, 360, s. k322. DOI:10.1136/bmj.k322

Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917888/



"Our results showed that a vegetarian diet is associated with poorer health (higher incidences of cancer, allergies, and mental health disorders), a higher need for health care, and poorer quality of life. Therefore, public health programs are needed in order to reduce the health risk due to nutritional factors."


Burkert NT, Muckenhuber J, Großschädl F, Rásky É, Freidl W.
Nutrition and Health – The Association between Eating Behavior and Various
Health Parameters: A Matched Sample Study. Gorlova OY, ed. PLoS ONE. 2014;9(2):e88278. doi:10.1371/journal.pone.0088278.

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0178-2

"Conclusions

Optimization of dosing, timing, and scheduling of the press-pulse therapeutic strategy will facilitate the eradication of tumor cells with minimal patient toxicity. This therapeutic strategy can be used as a framework for the design of clinical trials for the non-toxic management of most cancers."

Press-pulse: a novel therapeutic strategy for the metabolic management of cancerThomas N. SeyfriedEmail author, George Yu, Joseph C. Maroon and Dominic P. D’AgostinoNutrition & Metabolism201714:19https://doi.org/10.1186/s12986-017-0178-2©  The Author(s). 2017Received: 29 September 2016Accepted: 17 February 2017Published: 23 February 2017

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Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease | Niknamian | International Science and Investigation journal

http://isijournal.info/journals/index.php/ISIJ/article/view/252/197



Abstract

This review takes a deep look at increases in the incidence of cancer and heart disease after
the introduction of industrial vegetable oils in the world. Most vegetable oils are highly
processed and refined products, which completely lack the essential nutrients. Omega-6
Linoleic acid from vegetable oils increases oxidative stress in the body of humans, contributing
to endothelial dysfunction and heart disease. The consumption of these harmful oils which are
high in mega-6 polyunsaturated fats results in changing the structure of cell membrane which
contribute to increasing inflammation and the incidence of cancer.



Niknamian, S., & Kalamian, M. (2016). Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease. International Science And Investigation Journal, 5(5), 157-168. Retrieved from http://isijournal.info/journals/index.php/ISIJ/article/view/252/197

Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293152/



"Total vitamin D intake ≥400 versus <400 IU/d was associated with a lower risk of total lung cancer among participants who received the CARET active intervention (HR=0.56, 95% CI=0.32–0.99) and among those who had total vitamin A intake ≥1,500 μg/d Retinol Activity Equivalent (RAE; HR=0.46, 95% CI=0.23–0.91). The beneficial associations were attenuated among those who did not receive the CARET active intervention or who had total vitamin A intake <1,500 μg/d RAE (P-interaction=0.02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers."



Cheng T-YD, Goodman GE, Thornquist MD, et al. Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.International journal of cancer Journal international du cancer. 2014;135(9):2135-2145. doi:10.1002/ijc.28846.

Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/25008141

"CONCLUSIONS:

Vitamin A intake was inversely associated with gastric cancer risk, while no significant association was found with retinol intake or blood retinol level"

Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis.Wu Y, Ye Y, Shi Y, Li P, Xu J, Chen K, Xu E, Yang J.Clin Nutr. 2015 Aug;34(4):620-6. doi: 10.1016/j.clnu.2014.06.007. Epub 2014 Jun 23.PMID: 25008141

Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/m/pubmed/22840388/

CONCLUSION: "Preliminary data demonstrate that an insulin-inhibiting diet is safe and feasible in selected patients with advanced cancer. The extent of ketosis, but not calorie deficit or weight loss, correlated with stable disease or partial remission."


Nutrition. 2012 Oct;28(10):1028-35. doi: 10.1016/j.nut.2012.05.001. Epub 2012 Jul 26.

Health effects of vegetarian and vegan diets. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/16441942


"Studies of cancer have not shown clear differences in cancer rates between vegetarians and non-vegetarians."


Key TJ, Appleby PN, Rosell MS.
Proc Nutr Soc. 2006 Feb;65(1):35-41. Review.
PMID: 16441942

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

3 studies about Vitamin C and Cancer

Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences of the United States of America. 1976;73(10):3685-3689.
PMCID: PMC431183
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC431183/


Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer.Proceedings of the National Academy of Sciences of the United States of America. 1978;75(9):4538-4542.
PMCID: PMC336151
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC336151/


Cabanillas F. Vitamin C and cancer: what can we conclude--1,609 patients and
33 years later? P R Health Sci J. 2010 Sep;29(3):215-7. Review. PubMed
PMID: 20799507.
http://www.ncbi.nlm.nih.gov/pubmed/20799507

Antitumor activity of astaxanthin and its mode of action. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/10798217

Antitumor activity of astaxanthin and its mode of action.
Jyonouchi H, Sun S, Iijima K, Gross MD.
Nutr Cancer. 2000;36(1):59-65.
PMID: 10798217

Entropy | Free Full-Text | Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

http://www.mdpi.com/1099-4300/15/4/1416



Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide....

Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.

--------
A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver...



It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut....
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism...

Samsel
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.

Glyphosate induces human breast cancer cells growth via estrogen receptors. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/23756170

IJMS | Free Full-Text | Impacts of Gut Bacteria on Human Health and Diseases

http://www.mdpi.com/1422-0067/16/4/7493

Abstract: Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.

Zhang Y-J, Li S, Gan R-Y, Zhou T, Xu D-P, Li H-B. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015; 16(4):7493-7519.

Dominic D'Agostino: Metabolic Therapies: Therapeutic Implications and Practical Application

Metabolic therapies that induce a state of mild ketosis from caloric restriction or the ketogenic diet offer neuroprotection against a wide range of pathologies, and continues to be an emerging strategy for the metabolic management of cancer. Severe dietary restriction of calories or carbohydrates is typically needed to produce a level of ketosis that achieves therapeutic benefits. Interestingly, the strategy to use exogenous ketones as an alternative fuel has not been exploited therapeutically. When administered orally in controlled dosages, ketone esters and other ketogenic agents can lower glucose and elevate plasma ketone levels comparable to levels achieved by the most rigorous ketogenic diets. Metabolic therapies in the form of ketone supplementation offer a safe, convenient, and versatile new treatment approach for a variety of diseases, including seizure disorders, neurodegenerative diseases and cancer.