Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

 https://pubmed.ncbi.nlm.nih.gov/33668240/

” Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.”

Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.

“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub

Conclusion

"Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19."

 

 Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R. & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology, 203, s. 105751. doi:https://doi.org/10.1016/j.jsbmb.2020.105751

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model | bioRxiv

https://www.biorxiv.org/content/10.1101/2020.09.11.294363v1





These data underscore the value of mCoV-A59 model to test mechanism and
establishes harnessing of the ketogenic immunometabolic checkpoint as a
potential treatment against COVID-19 in the elderly.



 Ryu, S. et al. (2020). Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv, s. 2020.09.11.294363. doi:10.1101/2020.09.11.294363

Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths - PubMed

https://pubmed.ncbi.nlm.nih.gov/32252338/



"To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L)."

Grant WB, Lahore H,
McDonnell SL, et al. Evidence that Vitamin D Supplementation Could
Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):E988. Published 2020 Apr 2. doi:10.3390/nu12040988

Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China by Xingzhong Hu, Dong Chen, Lianpeng Wu, Guiqing He, Wei Ye :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3544826&utm_source=EC&utm_medium=Connect



Interpretation: Low serum cholesterol level in the patients with COVID-19 in Wenzhou, China. Altered serum cholesterol provide important information, and is meaningful to understand the disease.

Hu, Xingzhong and Chen, Dong and Wu, Lianpeng and He, Guiqing and
Ye, Wei, Low Serum Cholesterol Level Among Patients with COVID-19
Infection in Wenzhou, China (February 21, 2020). Available at SSRN: https://ssrn.com/abstract=3544826