onsdag 22 mars 2017

A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/25760553/



RESULTS: At the age of 13 y, ADHD or Asperge was diagnosed in 6/35 (17.1%) children in the placebo and none in the probiotic group.



Pediatr Res. 2015 Jun;77(6):823-8. doi: 10.1038/pr.2015.51. Epub 2015 Mar 11.


Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/26046241/





FINDINGS: Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, and essential metabolites all convey information to the central nervous system about the intestinal state. Conversely, the hypothalamic-pituitary-adrenal axis, the central nervous system regulatory areas of satiety, and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions seem to influence the pathogenesis of a number of disorders in which inflammation is implicated, such as mood disorder, autism-spectrum disorders, attention-deficit hypersensitivity disorder, multiple sclerosis, and obesity.



Clin Ther. 2015 May 1;37(5):984-95. doi: 10.1016/j.clinthera.2015.04.002.