"In nonobeseadults, Calorie Restriction had some positive effects and no negative effects on health-related quality of life."
Martin CK, Bhapkar M, Pittas AG, et al. Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. JAMA Intern Med.2016;176(6):743-752. doi:10.1001/jamainternmed.2016.1189.