Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/

Conclusion

Subclinical magnesium deficiency is a common and under-recognised problem throughout the world. Importantly, subclinical magnesium deficiency does not manifest as clinically apparent symptoms and thus is not easily recognised by the clinician. Despite this fact, subclinical magnesium deficiency likely leads to hypertension, arrhythmias, arterial calcifications, atherosclerosis, heart failure and an increased risk for thrombosis. This suggests that subclinical magnesium deficiency is a principal, yet under-recognised, driver of cardiovascular disease. 

Open Heart. 2018; 5(1): e000668. 

Published online 2018 Jan 13. doi: 10.1136/openhrt-2017-000668

PMCID: PMC5786912

PMID: 29387426

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? - PubMed

https://pubmed.ncbi.nlm.nih.gov/21885251/

 

Abstract

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.

 

Seyfried TN, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26. doi: 10.1016/j.eplepsyres.2011.06.017. Epub 2011 Aug 31. PMID: 21885251.

 

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

https://jamanetwork.com/journals/jama/fullarticle/2758712

”Six weeks after completing the modified ketogenic diet, patients had improved Alzheimer disease biomarkers in their cerebrospinal fluid. “With the ketogenic diet, we are moving the β-amyloid in a healthier direction,” Craft said. Patients also had better blood flow to the hippocampus and improved body-wide insulin sensitivity. A larger trial of the modified ketogenic diet is now under way.”

Kuehn BM. In Alzheimer Research, Glucose Metabolism Moves to Center Stage. JAMA.2020;323(4):297–299. doi:10.1001/jama.2019.20939

“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub

Conclusion

"Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19."

 

 Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R. & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology, 203, s. 105751. doi:https://doi.org/10.1016/j.jsbmb.2020.105751

Diet modulates brain network stability, a biomarker for brain aging, in young adults

 https://www.pnas.org/content/117/11/6170

”Targeted experiments show that this biomarker for brain aging is reliably modulated with consumption of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks.”

Listen to the Author Lilianne R. Mujica-Parodi talk about this paper at STEM-Talk podcast [00:59:33] into the podcast. https://podcasts.apple.com/se/podcast/stem-talk/id1091402153?i=1000496517254

Diet modulates brain network stability, a biomarker for brain aging, in young adults

Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, Kieran Clarke

Proceedings of the National Academy of Sciences Mar 2020, 117 (11) 6170-6177; DOI: 10.1073/pnas.1913042117

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model | bioRxiv

https://www.biorxiv.org/content/10.1101/2020.09.11.294363v1





These data underscore the value of mCoV-A59 model to test mechanism and
establishes harnessing of the ketogenic immunometabolic checkpoint as a
potential treatment against COVID-19 in the elderly.



 Ryu, S. et al. (2020). Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv, s. 2020.09.11.294363. doi:10.1101/2020.09.11.294363

Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet | Journal of Agricultural and Food Chemistry

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.0c04604?fbclid=IwAR3NQr1SoE8l4biBINF2exSmPzSDthUykseDvf7FR1VaiZiP3Ub9MHIgong&





In conclusion, ketogenic diet exerted a neuroprotective effect on cuprizone-induced
demyelination mice, and this activity was associated with the modulation
of the SIRT1/PPAR-γ and SIRT1/P-Akt/mTOR pathways.



J. Agric. Food Chem. 2020, XXXX, XXX, XXX-XXX

Publication Date:September 12, 2020

https://doi.org/10.1021/acs.jafc.0c04604

Sträng diet förklarar fetmakirurgins makt | Diabetesportalen

https://www.diabetesportalen.lu.se/article/strang-diet-forklarar-fetmakirurgins-makt


Sträng diet förklarar fetmakirurgins makt

"Resultatet visar att dieten ensam stod för den största positiva effekten.

– Mer än 90 procent av allt som hände, skedde till följd av dieten, väldigt
lite förändrades efter kirurgin"


Diabetesportalen
https://www.diabetesportalen.lu.se/article/strang-diet-forklarar-fetmakirurgins-makt

 

Herzog K, Berggren J, Al Majdoub M, et al. Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories?. Diabetes. 2020;69(9):2027-2035. doi:10.2337/db20-0131

 https://pubmed.ncbi.nlm.nih.gov/32527768/

 

 

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial | The BMJ

https://www.bmj.com/content/363/bmj.k4583



Conclusions Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.

Ebbeling Cara B, Feldman Henry A, Klein Gloria L, Wong Julia M W, Bielak Lisa, Steltz Sarah K et al.Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial BMJ 2018; 363 :k4583

To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease | Advances in Nutrition | Oxford Academic

https://academic.oup.com/advances/article-abstract/doi/10.1093/advances/nmaa073/5864685



""... interventions, and outcome measures, ketogenic therapy appears promising
in improving both acute and long-term cognition among patients with
Alzheimer disease/mild cognitive impairment."


Maria G Grammatikopoulou, Dimitrios G Goulis, Konstantinos Gkiouras,
Xenophon Theodoridis, Kalliopi K Gkouskou, Athanasios Evangeliou,
Efthimis Dardiotis, Dimitrios P Bogdanos, To Keto or Not to Keto? A
Systematic Review of Randomized Controlled Trials Assessing the Effects
of Ketogenic Therapy on Alzheimer Disease, Advances in Nutrition, , nmaa073, https://doi.org/10.1093/advances/nmaa073

Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths - PubMed

https://pubmed.ncbi.nlm.nih.gov/32252338/



"To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L)."

Grant WB, Lahore H,
McDonnell SL, et al. Evidence that Vitamin D Supplementation Could
Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):E988. Published 2020 Apr 2. doi:10.3390/nu12040988

Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S1874391920300130



Highlights

• First human serum proteomics study of 30-day intermittent fasting from dawn to sunset in healthy subjects 
• The 30-day intermittent fasting from dawn to sunset is associated with a serum proteome protective against cancer 
• Intermittent fasting from dawn to sunset for 30 days upregulates proteins protective against obesity, diabetes, and metabolic syndrome 
• Intermittent fasting from dawn to sunset for 30 days induces key regulatory proteins of DNA repair and immune system 
• Intermittent fasting from dawn to sunset for 30 days upregulates proteins protective against Alzheimer’s disease and neuropsychiatric disorders

Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study | The American Journal of Clinical Nutrition | Oxford Academic

https://academic.oup.com/ajcn/article/92/1/194/4597302


Conclusions: Milk fat biomarkers were associated with a lower risk of developing a first myocardial infarction, especially in women.


Eva Warensjö, Jan-Håkan Jansson, Tommy Cederholm, Kurt Boman, Mats
Eliasson, Göran Hallmans, Ingegerd Johansson, Per Sjögren, Biomarkers
of milk fat and the risk of myocardial infarction in men and women: a
prospective, matched case-control study, The American Journal of Clinical Nutrition, Volume 92, Issue 1, July 2010, Pages 194–202, https://doi.org/10.3945/ajcn.2009.29054

Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China by Xingzhong Hu, Dong Chen, Lianpeng Wu, Guiqing He, Wei Ye :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3544826&utm_source=EC&utm_medium=Connect



Interpretation: Low serum cholesterol level in the patients with COVID-19 in Wenzhou, China. Altered serum cholesterol provide important information, and is meaningful to understand the disease.

Hu, Xingzhong and Chen, Dong and Wu, Lianpeng and He, Guiqing and
Ye, Wei, Low Serum Cholesterol Level Among Patients with COVID-19
Infection in Wenzhou, China (February 21, 2020). Available at SSRN: https://ssrn.com/abstract=3544826