Dietary Carbohydrates Impair Healthspan and Promote Mortality: Cell Metabolism

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30562-4


The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.

Dietary Carbohydrates Impair Healthspan and Promote Mortality

Ravichandran, Meenakshi et al.

Cell Metabolism , Volume 26 , Issue 4 , 585 - 587

Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917888/



"Our results showed that a vegetarian diet is associated with poorer health (higher incidences of cancer, allergies, and mental health disorders), a higher need for health care, and poorer quality of life. Therefore, public health programs are needed in order to reduce the health risk due to nutritional factors."


Burkert NT, Muckenhuber J, Großschädl F, Rásky É, Freidl W.
Nutrition and Health – The Association between Eating Behavior and Various
Health Parameters: A Matched Sample Study. Gorlova OY, ed. PLoS ONE. 2014;9(2):e88278. doi:10.1371/journal.pone.0088278.

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity - Gastroenterology

http://www.gastrojournal.org/article/S0016-5085(17)35685-8/fulltext


"Conclusions Short-term (9 days) isocaloric fructose restriction decreased liver fat, VAT, and DNL, and improved insulin kinetics in children with obesity. These findings support efforts to reduce sugar consumption. ClinicalTrials.gov Number: NCT01200043."

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity

Schwarz, Jean-Marc et al.

Gastroenterology , Volume 153 , Issue 3 , 743 - 752

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study - The Lancet

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext

"Interpretation

High carbohydrate intake was associated with higher risk of total mortality, whereas total fat and individual types of fat were related to lower total mortality. Total fat and types of fat were not associated with cardiovascular disease, myocardial infarction, or cardiovascular disease mortality, whereas saturated fat had an inverse association with stroke. Global dietary guidelines should be reconsidered in light of these findings."

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study - The Lancet, DOI: http://dx.doi.org/10.1016/S0140-6736(17)32252-3

Refeeding syndrome: what it is, and how to prevent and treat it

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440847/



"Refeeding syndrome: what it is, and how to prevent and treat it"



Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ : British Medical Journal. 2008;336(7659):1495-1498. doi:10.1136/bmj.a301.

Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study | SpringerLink

https://link.springer.com/article/10.1007/s11011-017-0088-z



"Both diet groups showed significant improvement in ATEC and CARS scores in comparison to control group, yet ketogenic scored better results in cognition and sociability compared to GFCF diet group."



El-Rashidy, O., El-Baz, F., El-Gendy, Y. et al. Metab Brain Dis (2017). https://doi.org/10.1007/s11011-017-0088-z

Study Puts Smart Drugs Back in Spotlight | Adolescent Medicine | JAMA | The JAMA Network

http://jamanetwork.com/journals/jama/fullarticle/2649239

"A group of 39 highly rated male members of the German Chess Federation were enlisted to play more than 3000 15-minute games against computers matched to their skill levels while taking modafinil, methylphenidate, or caffeine. The researchers reported that players taking modafinil and methylphenidate won more games overall, though they pondered their moves longer, causing them to sometimes lose on time."

"The positive association surprised Lieb. “Our hypothesis [had been] that it’s not possible to enhance subjects who are already working at top performance,” he said."

Lyon J. Chess Study Revives Debate Over Cognition-Enhancing Drugs. JAMA. Published online August 16, 2017. doi:10.1001/jama.2017.8114

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0178-2

"Conclusions

Optimization of dosing, timing, and scheduling of the press-pulse therapeutic strategy will facilitate the eradication of tumor cells with minimal patient toxicity. This therapeutic strategy can be used as a framework for the design of clinical trials for the non-toxic management of most cancers."

Press-pulse: a novel therapeutic strategy for the metabolic management of cancerThomas N. SeyfriedEmail author, George Yu, Joseph C. Maroon and Dominic P. D’AgostinoNutrition & Metabolism201714:19https://doi.org/10.1186/s12986-017-0178-2©  The Author(s). 2017Received: 29 September 2016Accepted: 17 February 2017Published: 23 February 2017

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Brain metabolism in health, aging, and neurodegeneration. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28438892/



"Emerging findings suggest that lifestyles that include intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, can increase the likelihood that the brain will function optimally and in the absence of disease throughout life."



EMBO J. 2017 Apr 24. pii: e201695810. doi: 10.15252/embj.201695810.

Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort - the 45 and Up Study. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28040519/



"We found no evidence that following a vegetarian diet, semi-vegetarian diet or a pesco-vegetarian diet has an independent protective effect on all-cause mortality."


Prev Med. 2017 Apr;97:1-7. doi: 10.1016/j.ypmed.2016.12.044. Epub 2016 Dec 29.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia | Stroke

http://stroke.ahajournals.org/content/48/5/1139



Conclusions—Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia

Matthew P. Pase, Jayandra J. Himali, Alexa S. Beiser, Hugo J. Aparicio, Claudia L. Satizabal, Ramachandran S. Vasan, Sudha Seshadri and Paul F. Jacques

Stroke. 2017;48:1139-1146, originally published April 24, 2017

 https://doi.org/10.1161/STROKEAHA.116.016027

Sugar addiction: pushing the drug-sugar analogy to the limit. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/23719144



"Overall, this research has revealed that sugar and sweet reward can not only substitute to addictive drugs, like cocaine, but can even be more rewarding and attractive."

Sugar addiction: pushing the drug-sugar analogy to the limit.Ahmed SH, Guillem K, Vandaele Y.Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8. Review.

The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/


Conclusions

Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.

Kasielski, M., Eusebio, M.-O., Pietruczuk, M., & Nowak, D. (2015). The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat. Nutrition Journal, 15, 68. http://doi.org/10.1186/s12937-016-0189-2

Livsmedelsverket – EU:s nya huvudlaboratorium för virus i livsmedel

https://www.livsmedelsverket.se/om-oss/press/nyheter/pressmeddelanden/livsmedelsverket-eus-nya-huvudlaboratorium-for-virus-i-livsmedel



"Uppemot 180 000 svenskar drabbas årligen av vinterkräksjuka via livsmedel."