Brain metabolism in health, aging, and neurodegeneration. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28438892/



"Emerging findings suggest that lifestyles that include intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, can increase the likelihood that the brain will function optimally and in the absence of disease throughout life."



EMBO J. 2017 Apr 24. pii: e201695810. doi: 10.15252/embj.201695810.

Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort - the 45 and Up Study. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/28040519/



"We found no evidence that following a vegetarian diet, semi-vegetarian diet or a pesco-vegetarian diet has an independent protective effect on all-cause mortality."


Prev Med. 2017 Apr;97:1-7. doi: 10.1016/j.ypmed.2016.12.044. Epub 2016 Dec 29.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia | Stroke

http://stroke.ahajournals.org/content/48/5/1139



Conclusions—Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia

Matthew P. Pase, Jayandra J. Himali, Alexa S. Beiser, Hugo J. Aparicio, Claudia L. Satizabal, Ramachandran S. Vasan, Sudha Seshadri and Paul F. Jacques

Stroke. 2017;48:1139-1146, originally published April 24, 2017

 https://doi.org/10.1161/STROKEAHA.116.016027

Sugar addiction: pushing the drug-sugar analogy to the limit. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/23719144



"Overall, this research has revealed that sugar and sweet reward can not only substitute to addictive drugs, like cocaine, but can even be more rewarding and attractive."

Sugar addiction: pushing the drug-sugar analogy to the limit.Ahmed SH, Guillem K, Vandaele Y.Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8. Review.

The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/


Conclusions

Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.

Kasielski, M., Eusebio, M.-O., Pietruczuk, M., & Nowak, D. (2015). The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat. Nutrition Journal, 15, 68. http://doi.org/10.1186/s12937-016-0189-2

Livsmedelsverket – EU:s nya huvudlaboratorium för virus i livsmedel

https://www.livsmedelsverket.se/om-oss/press/nyheter/pressmeddelanden/livsmedelsverket-eus-nya-huvudlaboratorium-for-virus-i-livsmedel



"Uppemot 180 000 svenskar drabbas årligen av vinterkräksjuka via livsmedel."

A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/25760553/



RESULTS: At the age of 13 y, ADHD or Asperge was diagnosed in 6/35 (17.1%) children in the placebo and none in the probiotic group.



Pediatr Res. 2015 Jun;77(6):823-8. doi: 10.1038/pr.2015.51. Epub 2015 Mar 11.

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/26046241/





FINDINGS: Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, and essential metabolites all convey information to the central nervous system about the intestinal state. Conversely, the hypothalamic-pituitary-adrenal axis, the central nervous system regulatory areas of satiety, and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions seem to influence the pathogenesis of a number of disorders in which inflammation is implicated, such as mood disorder, autism-spectrum disorders, attention-deficit hypersensitivity disorder, multiple sclerosis, and obesity.



Clin Ther. 2015 May 1;37(5):984-95. doi: 10.1016/j.clinthera.2015.04.002.

Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease | Niknamian | International Science and Investigation journal

http://isijournal.info/journals/index.php/ISIJ/article/view/252/197



Abstract

This review takes a deep look at increases in the incidence of cancer and heart disease after
the introduction of industrial vegetable oils in the world. Most vegetable oils are highly
processed and refined products, which completely lack the essential nutrients. Omega-6
Linoleic acid from vegetable oils increases oxidative stress in the body of humans, contributing
to endothelial dysfunction and heart disease. The consumption of these harmful oils which are
high in mega-6 polyunsaturated fats results in changing the structure of cell membrane which
contribute to increasing inflammation and the incidence of cancer.



Niknamian, S., & Kalamian, M. (2016). Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease. International Science And Investigation Journal, 5(5), 157-168. Retrieved from http://isijournal.info/journals/index.php/ISIJ/article/view/252/197

Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes | SpringerLink

http://link.springer.com/article/10.1007/s10545-016-0011-5


Conclusion

Ketogenic diet was an effective and safe treatment for the majority of patients. Treatment effect was mainly determined by disease phenotype and attainment and maintenance of ketosis.

Sofou, K., Dahlin, M., Hallböök, T. et al. J Inherit Metab Dis (2017). doi:10.1007/s10545-016-0011-5

Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide : Scientific Reports

http://www.nature.com/articles/srep39328





Abstract:

The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q < 0.05) were involved in organonitrogen metabolism and fatty acid β-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis. The metabolome analysis (55 metabolites altered out of 673 detected, p < 0.05) confirmed lipotoxic conditions and oxidative stress by showing an activation of glutathione and ascorbate free radical scavenger systems. Additionally, we found metabolite alterations associated with hallmarks of hepatotoxicity such as γ-glutamyl dipeptides, acylcarnitines, and proline derivatives. Overall, metabolome and proteome disturbances showed a substantial overlap with biomarkers of non-alcoholic fatty liver disease and its progression to steatohepatosis and thus confirm liver functional dysfunction resulting from chronic ultra-low dose GBH exposure.

• Scientific Reports 7, Article number: 39328 (2017)

• doi:10.1038/srep39328

Nutritional Ketosis Condition and Specific Ketogenic Diet, May Benefit Cancer Patients as an Alternative Treatment by Sudden Change in the Metabolic State of Cancer Cells. | Niknamian | International Science and Investigation journal

http://www.isijournal.info/journals/index.php/ISIJ/article/view/237

Abstract

Cancer disease is the second cause of death in the United States and world-wide. Most Researchers estimate that 595,690 of American people will die from cancer at the end of the year 2017. That means 1,600 deaths/day approximately.³⁹ Cancer in modern societies is commonly treated with the combination of organ surgery, chemotherapy and radiotherapy. Many kinds of diet strategies have been experimented. However, none of them have been particularly effective. Interestingly, there is some applied research suggesting that a very low-carb, high fat diet may help.^{40, 41, 42} According to Otto Warburg hypothesis, the cause of cancer is the change in the metabolism of mitochondrion in human cells. Low oxygen in tissues in combination with high blood glucose will change the cell respiration from aerobic to anaerobic which leads to fermentation type of respiration. In this perspective and prospective research, I have shown the very low carbohydrate ketogenic diet and mostly ketosis, may benefit cancer patients in reducing and weakening cancer cells. Although further researches are needed, this perspective article could be beneficial in future perspective of alternative treatments of cancer.




Niknamian, S. (2016). Nutritional Ketosis Condition and Specific Ketogenic Diet, May Benefit Cancer Patients as an Alternative Treatment by Sudden Change in the Metabolic State of Cancer Cells.. International Science And Investigation Journal, 5(5), 28-48. Retrieved from http://www.isijournal.info/journals/index.php/ISIJ/article/view/237

Bread and Other Edible Agents of Mental Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809873/

Abstract

Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. Here we attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains—the world’s most abundant food source—can affect human behavior and mental health. We present the implications for the psychological sciences of the findings that, in all of us, bread (1) makes the gut more permeable and can thus encourage the migration of food particles to sites where they are not expected, prompting the immune system to attack both these particles and brain-relevant substances that resemble them, and (2) releases opioid-like compounds, capable of causing mental derangement if they make it to the brain. A grain-free diet, although difficult to maintain (especially for those that need it the most), could improve the mental health of many and be a complete cure for others.

Bressan P, Kramer P. Bread and Other Edible Agents of Mental Disease. Frontiers in Human Neuroscience. 2016;10:130. doi:10.3389/fnhum.2016.00130.

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms. - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/27826689/