Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Tr... - PubMed - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/27136347


CONCLUSIONS AND RELEVANCE:

"In nonobese adults, Calorie Restriction had some positive effects and no negative effects on health-related quality of life."

Martin CK, Bhapkar M, Pittas AG, et al. Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. JAMA Intern Med.2016;176(6):743-752. doi:10.1001/jamainternmed.2016.1189.

Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

http://ajcn.nutrition.org/content/early/2016/02/10/ajcn.115.122317



Conclusion: "Egg or cholesterol intakes were not associated with increased CAD risk, even in ApoE4 carriers (i.e., in highly susceptible individuals)."




Am J Clin Nutr ajcn122317; First published online February 10, 2016. doi:10.3945/ajcn.115.122317

British Journal of Nutrition - Red meat from animals offered a grass diet increases plasma and platelet n-3 PUFA in healthy consumers - Cambridge Journals Online

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7948423&fulltextType=RA&fileId=S0007114510003090


Abstract

"Red meat from grass-fed animals, compared with concentrate-fed animals, contains increased concentrations of long-chain (LC) n-3 PUFA. However, the effects of red meat consumption from grass-fed animals on consumer blood concentrations of LC n-3 PUFA are unknown. The aim of the present study was to compare the effects on plasma and platelet LC n-3 PUFA status of consuming red meat produced from either grass-fed animals or concentrate-fed animals. A randomised, double-blinded, dietary intervention study was carried out for 4 weeks on healthy subjects who replaced their habitual red meat intake with three portions per week of red meat (beef and lamb) from animals offered a finishing diet of either grass or concentrate (n 20 consumers). Plasma and platelet fatty acid composition, dietary intake, blood pressure, and serum lipids and lipoproteins were analysed at baseline and post-intervention. Dietary intakes of total n-3 PUFA, as well as plasma and platelet concentrations of LC n-3 PUFA, were significantly higher in those subjects who consumed red meat from grass-fed animals compared with those who consumed red meat from concentrate-fed animals (P < 0·05). No significant differences in concentrations of serum cholesterol, TAG or blood pressure were observed between groups. Consuming red meat from grass-fed animals compared with concentrate-fed animals as part of the habitual diet can significantly increase consumer plasma and platelet LC n-3 PUFA status. As a result, red meat from grass-fed animals may contribute to dietary intakes of LC n-3 PUFA in populations where red meat is habitually consumed."

British Journal of Nutrition / Volume 105 / Issue 01 / January 2011, pp 80-89DOI: http://dx.doi.org/10.1017/S0007114510003090 (About DOI), Published online: 01 September 2010

Composition differences between organic and conventional meat: a systematic literature review and meta-analysis

http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN115_06%2FS0007114515005073a.pdf&code=7cac44be9bbc705374f024857fd4885c



Abstract

"Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95 % CI 11, 35) % and 47 (95 % CI 10, 84) %
higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed."



Średnicka-Tober, D., Barański, M., Seal, C., Sanderson, R., Benbrook, C., Steinshamn, H., Gromadzka-Ostrowska, J., Rembiałkowska, E., Skwarło-Sońta, K., Eyre, M., Cozzi, G., Krogh Larsen, M., Jordon, T., Niggli, U., Sakowski, T., Calder, P.C., Burdge, G.C., Sotiraki, S., Stefanakis, A., Yolcu, H., Stergiadis, S., Chatzidimitriou, E., Butler, G., Stewart, G. and Leifert, C. (2016) ‘Composition differences between organic and conventional meat: a systematic literature review and meta-analysis’,British Journal of Nutrition, 115(6), pp. 994–1011. doi: 10.1017/S0007114515005073.

Health effects of vegetarian and vegan diets. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/16441942


"Studies of cancer have not shown clear differences in cancer rates between vegetarians and non-vegetarians."


Key TJ, Appleby PN, Rosell MS.
Proc Nutr Soc. 2006 Feb;65(1):35-41. Review.
PMID: 16441942

Vegetarian diets, chronic diseases and longevity. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/19166134



Very probably, an ample consumption of fruits and vegetables and not the exclusion of meat make vegetarians healthful.

Ginter E.
Bratisl Lek Listy. 2008;109(10):463-6. Review.
PMID: 19166134

Metabolic characteristics of keto-adapted ultra-endurance runners - Metabolism - Clinical and Experimental

http://www.metabolismjournal.com/article/S0026-0495(15)00334-0/abstract?elsca1=etoc&amp;elsca2=email&amp;elsca3=0026-0495_201603_65_3_&amp;elsca4=Genetics%7CEndocrinology%7CDiabetes%7CCardiology

Background

Many successful ultra-endurance athletes have switched from a high-carbohydrate to a low-carbohydrate diet, but they have not previously been studied to determine the extent of metabolic adaptations.

Conclusion

Compared to highly trained ultra-endurance athletes consuming an HC diet, long-term keto-adaptation results in extraordinarily high rates of fat oxidation, whereas muscle glycogen utilization and repletion patterns during and after a 3 hour run are similar.


DOI: http://dx.doi.org/10.1016/j.metabol.2015.10.028

Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with ozone therapy | Rowen | African Journal of Infectious Diseases

http://www.ajol.info/index.php/ajid/article/view/126773





Background: Ebola Virus Disease (EVD) has ravaged three countries in West Africa. The mortality rate is extremely high, and it is perceived not only as threat to all of Africa but to the entire world. There is no known treatment to date other than administration of convalescent blood or experimental monoclonal antibodies, which both often fail. Ozone therapy (OT) has been in clinical use for decades and has been found to have physiological effects, which should directly inactivate the virus itself, as well as modulate its damaging effects. We present the scientific background and the possibility of ozone therapy as a cure or prevention for EVD in five consecutive patients.


Materials and Methods: Ozone therapy administration by a combination of direct intravenous gas administration, rectal gas administration and ozonized water was administered to three patients with known acute EVD, one with apparent acute infection, and one case of extremely high risk. Treatment was carried out for up to ten days despite fast total remission of symptoms. Vitamin C and glutathione supporting supplements were administered.
Results: Four symptomatic patients, three with test positive EVD confirmation and one (who suffered Ebola contaminated needle stick contamination three days earlier) without lab confirmation all remitted symptoms within 2-4 days and fully recovered. All four ill cases had an immediate recovery course upon initiation of therapy. The single case of non-symptomatic high-risk exposure treated preventively did not develop symptoms.


Conclusion: Ebola virus may have a very narrow window of redox infectivity capacity, which can be easily exploited with OT. OT may be a useful modality in EVD and other viral diseases and should be immediately studied to save lives that might otherwise be lost.



Rowen et al., Afr. J. Infect. Dis. (2016) 10 (1): 49– 54
http://dx.doi.org/10.4314/ajid.v10i1.10

FULL TEXT - A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom - International Journal of Case Reports and Images (IJCRI)

http://www.ijcasereportsandimages.com/archive/2015/012-2015-ijcri/CR-10582-12-2015-toth/ijcri-1058212201582-toth-full-text.php



"Conclusion: We opine that the Paleolithic ketogenic diet ensure normal glucose levels and can be maintained on the long-term in those patients with newly diagnosed T1DM with residual insulin secretion. It is important to emphasize, however, that in those patients with long-standing T1DM beta cells might have exhausted and therefore there may be a need for insulin replacement. In these cases, however, the Paleolithic ketogenic diet may be used as an adjunct in an attempt to likely prevent diabetic complications."




Tóth C, Clemens Z. A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom. Int J Case Rep Images 2015;6(12):753–758.

Personalized Nutrition by Prediction of Glycemic Responses: Cell

http://www.cell.com/abstract/S0092-8674(15)01481-6

Summary

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.

DOI: http://dx.doi.org/10.1016/j.cell.2015.11.001

SLEEP - Sleep and Antibody Response to Hepatitis B Vaccination

http://www.journalsleep.org/ViewAbstract.aspx?pid=28593

Conclusions:

"Short sleep duration in the natural environment may negatively affect in vivo antibody responses to novel antigens, providing a possible explanation for observed associations of poor sleep with increased susceptibility to infectious disease."

Prather AA; Hall M; Fury JM; Ross DC; Muldoon MF; Cohen S; Marsland AL. Sleep and antibody response to hepatitis B vaccination. SLEEP 2012;35(8):1063-1069.

Sleep and immune function

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256323/

Abstract

Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep–wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep facilitates the extravasation of T cells and their possible redistribution to lymph nodes. Moreover, such studies revealed a selectively enhancing influence of sleep on cytokines promoting the interaction between antigen presenting cells and T helper cells, like interleukin-12. Sleep on the night after experimental vaccinations against hepatitis A produced a strong and persistent increase in the number of antigen-specific Th cells and antibody titres. Together these findings indicate a specific role of sleep in the formation of immunological memory. This role appears to be associated in particular with the stage of slow wave sleep and the accompanying pro-inflammatory endocrine milieu that is hallmarked by high growth hormone and prolactin levels and low cortisol and catecholamine concentrations.

Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Archiv. 2012;463(1):121-137. doi:10.1007/s00424-011-1044-0.

Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism -- ScienceDaily

http://www.sciencedaily.com/releases/2007/06/070605121134.htm



"Over the past several years, animal studies have shown that high-fat, low-carbohydrate "ketogenic" diets cause demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which appear in the June 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatty acids -- and thereby burn calories"


Beth Israel Deaconess Medical Center. (2007, June 6). Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism. ScienceDaily. Retrieved October 31, 2015 from www.sciencedaily.com/releases/2007/06/070605121134.htm

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube