Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with ozone therapy | Rowen | African Journal of Infectious Diseases

http://www.ajol.info/index.php/ajid/article/view/126773





Background: Ebola Virus Disease (EVD) has ravaged three countries in West Africa. The mortality rate is extremely high, and it is perceived not only as threat to all of Africa but to the entire world. There is no known treatment to date other than administration of convalescent blood or experimental monoclonal antibodies, which both often fail. Ozone therapy (OT) has been in clinical use for decades and has been found to have physiological effects, which should directly inactivate the virus itself, as well as modulate its damaging effects. We present the scientific background and the possibility of ozone therapy as a cure or prevention for EVD in five consecutive patients.


Materials and Methods: Ozone therapy administration by a combination of direct intravenous gas administration, rectal gas administration and ozonized water was administered to three patients with known acute EVD, one with apparent acute infection, and one case of extremely high risk. Treatment was carried out for up to ten days despite fast total remission of symptoms. Vitamin C and glutathione supporting supplements were administered.
Results: Four symptomatic patients, three with test positive EVD confirmation and one (who suffered Ebola contaminated needle stick contamination three days earlier) without lab confirmation all remitted symptoms within 2-4 days and fully recovered. All four ill cases had an immediate recovery course upon initiation of therapy. The single case of non-symptomatic high-risk exposure treated preventively did not develop symptoms.


Conclusion: Ebola virus may have a very narrow window of redox infectivity capacity, which can be easily exploited with OT. OT may be a useful modality in EVD and other viral diseases and should be immediately studied to save lives that might otherwise be lost.



Rowen et al., Afr. J. Infect. Dis. (2016) 10 (1): 49– 54
http://dx.doi.org/10.4314/ajid.v10i1.10

FULL TEXT - A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom - International Journal of Case Reports and Images (IJCRI)

http://www.ijcasereportsandimages.com/archive/2015/012-2015-ijcri/CR-10582-12-2015-toth/ijcri-1058212201582-toth-full-text.php



"Conclusion: We opine that the Paleolithic ketogenic diet ensure normal glucose levels and can be maintained on the long-term in those patients with newly diagnosed T1DM with residual insulin secretion. It is important to emphasize, however, that in those patients with long-standing T1DM beta cells might have exhausted and therefore there may be a need for insulin replacement. In these cases, however, the Paleolithic ketogenic diet may be used as an adjunct in an attempt to likely prevent diabetic complications."




Tóth C, Clemens Z. A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom. Int J Case Rep Images 2015;6(12):753–758.

Personalized Nutrition by Prediction of Glycemic Responses: Cell

http://www.cell.com/abstract/S0092-8674(15)01481-6

Summary

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.

DOI: http://dx.doi.org/10.1016/j.cell.2015.11.001

SLEEP - Sleep and Antibody Response to Hepatitis B Vaccination

http://www.journalsleep.org/ViewAbstract.aspx?pid=28593

Conclusions:

"Short sleep duration in the natural environment may negatively affect in vivo antibody responses to novel antigens, providing a possible explanation for observed associations of poor sleep with increased susceptibility to infectious disease."

Prather AA; Hall M; Fury JM; Ross DC; Muldoon MF; Cohen S; Marsland AL. Sleep and antibody response to hepatitis B vaccination. SLEEP 2012;35(8):1063-1069.

Sleep and immune function

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256323/

Abstract

Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep–wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep facilitates the extravasation of T cells and their possible redistribution to lymph nodes. Moreover, such studies revealed a selectively enhancing influence of sleep on cytokines promoting the interaction between antigen presenting cells and T helper cells, like interleukin-12. Sleep on the night after experimental vaccinations against hepatitis A produced a strong and persistent increase in the number of antigen-specific Th cells and antibody titres. Together these findings indicate a specific role of sleep in the formation of immunological memory. This role appears to be associated in particular with the stage of slow wave sleep and the accompanying pro-inflammatory endocrine milieu that is hallmarked by high growth hormone and prolactin levels and low cortisol and catecholamine concentrations.

Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Archiv. 2012;463(1):121-137. doi:10.1007/s00424-011-1044-0.

Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism -- ScienceDaily

http://www.sciencedaily.com/releases/2007/06/070605121134.htm



"Over the past several years, animal studies have shown that high-fat, low-carbohydrate "ketogenic" diets cause demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which appear in the June 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatty acids -- and thereby burn calories"


Beth Israel Deaconess Medical Center. (2007, June 6). Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism. ScienceDaily. Retrieved October 31, 2015 from www.sciencedaily.com/releases/2007/06/070605121134.htm

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581011/

Results

We administered KD for 2 years. Soon after the first six months, the patient was free of epileptic crises, presented normalization of EEG, and showed a marked recover in psychological development and quality of life.

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/26362286


CONCLUSIONS:
Resveratrol was safe and well-tolerated. Resveratrol and its major metabolites penetrated the blood-brain barrier to have CNS effects. Further studies are required to interpret the biomarker changes associated with resveratrol treatment.


Ät Dig Frisk anmärkning:
Resveratrol är kanske mest känd för att finnas i Vin, men bara för att resveratrol finns i vin, så betyder det inte att vin är nyttigt. För att komma upp i de doser man använt i denna studie så behöver man dricka upp till 1´000 FLASKOR vin om dagen.
http://time.com/4032194/red-wine-alzheimers/

Rethinking fat as a fuel for endurance exercise. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/25275931





Abstract

...... Beyond simply providing a stable source of fuel for the brain, the major circulating ketone body, beta-hydroxybutyrate, has recently been shown to act as a signalling molecule capable of altering gene expression, eliciting complementary effects of keto-adaptation that could extend human physical and mental performance beyond current expectation ......

What the Inuit can tell us about omega-3 fats and ‘paleo’ diets | Berkeley News

http://news.berkeley.edu/2015/09/17/what-the-inuit-can-tell-us-about-omega-3-fats-and-paleo-diets/



The traditional diet of Greenland natives — the Inuit — is held up as an example of how high levels of omega-3 fatty acids can counterbalance the bad health effects of a high-fat diet, but a new study hints that what’s true for the Inuit may not be true for everyone else.

PLOS ONE: High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133286

Abstract

Physical activity improves the regulation of glucose homeostasis in both type 2 diabetes (T2D) patients and healthy individuals, but the effect on pancreatic β cell function is unknown. We investigated glycaemic control, pancreatic function and total fat mass before and after 8 weeks of low volume high intensity interval training (HIIT) on cycle ergometer in T2D patients and matched healthy control individuals. Study design/method: Elderly (56 yrs±2), non-active T2D patients (n = 10) and matched (52 yrs±2) healthy controls (CON) (n = 13) exercised 3 times (10×60 sec. HIIT) a week over an 8 week period on a cycle ergometer. Participants underwent a 2-hour oral glucose tolerance test (OGTT). On a separate day, resting blood pressure measurement was conducted followed by an incremental maximal oxygen uptake (O2max) cycle ergometer test. Finally, a whole body dual X-ray absorptiometry (DXA) was performed. After 8 weeks of training, the same measurements were performed. Results: in the T2D-group, glycaemic control as determined by average fasting venous glucose concentration (p = 0.01), end point 2-hour OGTT (p = 0.04) and glycosylated haemoglobin (p = 0.04) were significantly reduced. Pancreatic homeostasis as determined by homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA β cell function (HOMA-%β) were both significantly ameliorated (p = 0.03 and p = 0.03, respectively). Whole body insulin sensitivity as determined by the disposition index (DI) was significantly increased (p = 0.03). During OGTT, the glucose continuum was significantly reduced at -15 (p = 0.03), 30 (p = 0.03) and 120 min (p = 0.03) and at -10 (p = 0.003) and 0 min (p = 0.003) with an additional improvement (p = 0.03) of its 1stphase (30 min) area under curve (AUC). Significant abdominal fat mass losses were seen in both groups (T2D: p = 0.004 and CON: p = 0.02) corresponding to a percentage change of -17.84%±5.02 and -9.66%±3.07, respectively. Conclusion: these results demonstrate that HIIT improves overall glycaemic control and pancreatic β cell function in T2D patients. Additionally, both groups experienced abdominal fat mass losses. These findings demonstrate that HIIT is a health beneficial exercise strategy in T2D patients.

The Power of Protein at Breakfast for School-­Aged Children

https://www.uaex.edu/publications/PDF/FSFCS86.pdf

Easy Ways to Add More Protein
to Breakfast
It is easy to incorporate more protein into
children’s breakfasts. Here are a couple of ideas for
including more high­quality protein in breakfast:

• Eggs: Make a breakfast burrito or a breakfast
  sandwich with scrambled eggs for a portable
  breakfast. Eggs can also be served with toast
  or prepared in an omelet with low­fat cheese
  and vegetables. 
• Dairy: Adding Greek yogurt to fruit smoothies is
  a way to add 10­15 grams of protein to a child’s
  breakfast. Eating low­fat regular or Greek
  yogurt by itself or mixed with cereal and fruit is
  another way to add protein to breakfast.
• Breakfast meats: Add lean breakfast meats
  such as turkey bacon, turkey sausage or
  Canadian bacon to breakfast.

Antioxidants prevent health-promoting effects of physical exercise in humans - PNAS

http://www.pnas.org/content/106/21/8665.long





Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.


Svenska via Google translate:
Tillskott med antioxidanter kan hindra dessa hälsofrämjande effekter av träning på människor.



Biological Sciences - Medical Sciences:
Michael Ristow, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C. Ronald Kahn, and Matthias Blüher

Antioxidants prevent health-promoting effects of physical exercise in humans
PNAS 2009 106 (21) 8665-8670; published ahead of print May 11, 2009, doi:10.1073/pnas.0903485106