Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism -- ScienceDaily

http://www.sciencedaily.com/releases/2007/06/070605121134.htm



"Over the past several years, animal studies have shown that high-fat, low-carbohydrate "ketogenic" diets cause demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which appear in the June 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatty acids -- and thereby burn calories"


Beth Israel Deaconess Medical Center. (2007, June 6). Low-Carb Diet Finding: Study Identifies New Regulator Of Fat Metabolism. ScienceDaily. Retrieved October 31, 2015 from www.sciencedaily.com/releases/2007/06/070605121134.htm

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege - YouTube

Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581011/

Results

We administered KD for 2 years. Soon after the first six months, the patient was free of epileptic crises, presented normalization of EEG, and showed a marked recover in psychological development and quality of life.

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/26362286


CONCLUSIONS:
Resveratrol was safe and well-tolerated. Resveratrol and its major metabolites penetrated the blood-brain barrier to have CNS effects. Further studies are required to interpret the biomarker changes associated with resveratrol treatment.


Ät Dig Frisk anmärkning:
Resveratrol är kanske mest känd för att finnas i Vin, men bara för att resveratrol finns i vin, så betyder det inte att vin är nyttigt. För att komma upp i de doser man använt i denna studie så behöver man dricka upp till 1´000 FLASKOR vin om dagen.
http://time.com/4032194/red-wine-alzheimers/

Rethinking fat as a fuel for endurance exercise. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/25275931





Abstract

...... Beyond simply providing a stable source of fuel for the brain, the major circulating ketone body, beta-hydroxybutyrate, has recently been shown to act as a signalling molecule capable of altering gene expression, eliciting complementary effects of keto-adaptation that could extend human physical and mental performance beyond current expectation ......

What the Inuit can tell us about omega-3 fats and ‘paleo’ diets | Berkeley News

http://news.berkeley.edu/2015/09/17/what-the-inuit-can-tell-us-about-omega-3-fats-and-paleo-diets/



The traditional diet of Greenland natives — the Inuit — is held up as an example of how high levels of omega-3 fatty acids can counterbalance the bad health effects of a high-fat diet, but a new study hints that what’s true for the Inuit may not be true for everyone else.

PLOS ONE: High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133286

Abstract

Physical activity improves the regulation of glucose homeostasis in both type 2 diabetes (T2D) patients and healthy individuals, but the effect on pancreatic β cell function is unknown. We investigated glycaemic control, pancreatic function and total fat mass before and after 8 weeks of low volume high intensity interval training (HIIT) on cycle ergometer in T2D patients and matched healthy control individuals. Study design/method: Elderly (56 yrs±2), non-active T2D patients (n = 10) and matched (52 yrs±2) healthy controls (CON) (n = 13) exercised 3 times (10×60 sec. HIIT) a week over an 8 week period on a cycle ergometer. Participants underwent a 2-hour oral glucose tolerance test (OGTT). On a separate day, resting blood pressure measurement was conducted followed by an incremental maximal oxygen uptake (O2max) cycle ergometer test. Finally, a whole body dual X-ray absorptiometry (DXA) was performed. After 8 weeks of training, the same measurements were performed. Results: in the T2D-group, glycaemic control as determined by average fasting venous glucose concentration (p = 0.01), end point 2-hour OGTT (p = 0.04) and glycosylated haemoglobin (p = 0.04) were significantly reduced. Pancreatic homeostasis as determined by homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA β cell function (HOMA-%β) were both significantly ameliorated (p = 0.03 and p = 0.03, respectively). Whole body insulin sensitivity as determined by the disposition index (DI) was significantly increased (p = 0.03). During OGTT, the glucose continuum was significantly reduced at -15 (p = 0.03), 30 (p = 0.03) and 120 min (p = 0.03) and at -10 (p = 0.003) and 0 min (p = 0.003) with an additional improvement (p = 0.03) of its 1stphase (30 min) area under curve (AUC). Significant abdominal fat mass losses were seen in both groups (T2D: p = 0.004 and CON: p = 0.02) corresponding to a percentage change of -17.84%±5.02 and -9.66%±3.07, respectively. Conclusion: these results demonstrate that HIIT improves overall glycaemic control and pancreatic β cell function in T2D patients. Additionally, both groups experienced abdominal fat mass losses. These findings demonstrate that HIIT is a health beneficial exercise strategy in T2D patients.

The Power of Protein at Breakfast for School-­Aged Children

https://www.uaex.edu/publications/PDF/FSFCS86.pdf

Easy Ways to Add More Protein
to Breakfast
It is easy to incorporate more protein into
children’s breakfasts. Here are a couple of ideas for
including more high­quality protein in breakfast:

• Eggs: Make a breakfast burrito or a breakfast
  sandwich with scrambled eggs for a portable
  breakfast. Eggs can also be served with toast
  or prepared in an omelet with low­fat cheese
  and vegetables. 
• Dairy: Adding Greek yogurt to fruit smoothies is
  a way to add 10­15 grams of protein to a child’s
  breakfast. Eating low­fat regular or Greek
  yogurt by itself or mixed with cereal and fruit is
  another way to add protein to breakfast.
• Breakfast meats: Add lean breakfast meats
  such as turkey bacon, turkey sausage or
  Canadian bacon to breakfast.

Antioxidants prevent health-promoting effects of physical exercise in humans - PNAS

http://www.pnas.org/content/106/21/8665.long





Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.


Svenska via Google translate:
Tillskott med antioxidanter kan hindra dessa hälsofrämjande effekter av träning på människor.



Biological Sciences - Medical Sciences:
Michael Ristow, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C. Ronald Kahn, and Matthias Blüher

Antioxidants prevent health-promoting effects of physical exercise in humans
PNAS 2009 106 (21) 8665-8670; published ahead of print May 11, 2009, doi:10.1073/pnas.0903485106

Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/26109578



Results:
...
Dietary cholesterol was not statistically significantly associated with any coronary artery disease...
ischemic stroke or hemorrhagic stroke.

...
Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.





Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis.
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ.
Am J Clin Nutr. 2015 Aug;102(2):276-94. doi: 10.3945/ajcn.114.100305. Epub 2015 Jun 24.
PMID: 26109578

PLOS ONE: Man the Fat Hunter: The Demise of Homo erectus and the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr) Levant

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028689

Abstract

The worldwide association of H. erectus with elephants is well documented and so is the preference of humans for fat as a source of energy. We show that rather than a matter of preference, H. erectus in the Levant was dependent on both elephants and fat for his survival. The disappearance of elephants from the Levant some 400 kyr ago coincides with the appearance of a new and innovative local cultural complex – the Levantine Acheulo-Yabrudian and, as is evident from teeth recently found in the Acheulo-Yabrudian 400-200 kyr site of Qesem Cave, the replacement of H. erectus by a new hominin. We employ a bio-energetic model to present a hypothesis that the disappearance of the elephants, which created a need to hunt an increased number of smaller and faster animals while maintaining an adequate fat content in the diet, was the evolutionary drive behind the emergence of the lighter, more agile, and cognitively capable hominins. Qesem Cave thus provides a rare opportunity to study the mechanisms that underlie the emergence of our post-erectus ancestors, the fat hunters.

Citation: Ben-Dor M, Gopher A, Hershkovitz I, Barkai R (2011)
Man the Fat Hunter: The Demise of Homo erectus and
the Emergence of a New Hominin Lineage in the Middle Pleistocene (ca. 400 kyr)
Levant. PLoS ONE 6(12): e28689. doi:10.1371/journal.pone.0028689

PEER-REVIEWED PAPER SUGGESTS GENETICALLY ENGINEERED SOY (GMO) PRODUCES EXCESS FORMALDEHYDE AND DISRUPTS NATURAL PLANT METABOLISM | International Center for Integrative Systems

http://www.integrativesystems.org/systems-biology-of-gmos/

Ayyadurai, V.A.S. and Deonikar, P. (2015) Do GMOs Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria? Systems Biology May Provide Answers. Agricultural Sciences, 6, 630-662. doi:10.4236/as.2015.67062.

Eat more salt and live longer (especially if you have had a cardiovascular event)

04:00 - Funnel plost - Publication Bias

08:20 - Causation vs Association Studies

09:50 - journal NEJM back in 1972

there is a bit of concern about the low salt diet. You can lower blood pressure okay nobody's disputing that but there's a price to pay, you're going to raise a renin and aldosterone levels  fairly substantially. So while you may lower your blood pressure you may actually put yourself at higher risk have coronary artery disease.

http://jama.jamanetwork.com/article.aspx?articleid=187486&resultClick=3

10:39 - Intrasalt Study (the main reason for recent advice to lower salt comsumption)

http://ajcn.nutrition.org/content/65/2/626S.abstract

17:00 - Salt and Mortality.

If you eat less salt, you are more likely to die

As you take a high-salt diet your mortality, goes down

As you take more more salt, cardiovascular disease goes down

http://www.cdc.gov/nchs/nhanes/nhanesi.htm

20:20 - People with high blood pressure, the people the guideline tells to eat less salt.

 Cardiovascular event rate for people as they take more more salt their cardiovascular  evnt rate goes down and down

http://hyper.ahajournals.org/content/25/6/1144.short

23:20 - Journal of the American Medical Association

They took 3,685 people and they followed them for seven point nine year

You had 23 times increase in your cardiac event ray when you take a low-salt diet, it looks pretty bad

http://www.ncbi.nlm.nih.gov/pubmed/21540421

25:10 - Another cochran review

there was one group that it looked like urs actually very harmful to follow a low-salt diet back group was the cardiac patients, so the people with heart failure the ones I you all tell to eat a low salt diet, they seem to do much worse, much worse than everybody else

http://www.cochrane.org/CD009217/VASC_reduced-dietary-salt-for-the-prevention-of-cardiovascular-disease

25:30 - Potential Harm From Too Little Salt Intake (The National Academies of Sciences)

Especially for those people with heart failure you want to be very very careful because the low salt diet might be extremely harmful to you okay it's not only not good for you but it might be actually very harmful to you and that everything else was that there was a really enough

Evidence indicates that low sodium intake may lead to risk of adverse health effects among those with mid- to late-stage heart failure who are receiving aggressive treatment for their disease

http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=18311

27:10 - Tradeoffs for low sodium intake

Blood Pressure - 3.85 % Decrease (best-case scenario)

Renin (hormone) + 24.3 % Increase

Aldosterone (hormone) + 24.5 % Increase

Adrenaline (hormone) + 9 % Increase

28:20 - The modern treatment for atherosclerosis

Renin - Renin inhibitors are used to treat hypertension

Aldosterone - spironolactone, ARBs & ACE Inhibitors are used to treat high levels of Aldosterone

Adrenaline - is blocked with Beta Blocker

Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/25346455



CONCLUSION:

The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.