fredag 26 juni 2015
3 studies about Vitamin C and Cancer
Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences of the United States of America. 1976;73(10):3685-3689.
PMCID: PMC431183
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC431183/
Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer.Proceedings of the National Academy of Sciences of the United States of America. 1978;75(9):4538-4542.
PMCID: PMC336151
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC336151/
Cabanillas F. Vitamin C and cancer: what can we conclude--1,609 patients and
33 years later? P R Health Sci J. 2010 Sep;29(3):215-7. Review. PubMed
PMID: 20799507.
http://www.ncbi.nlm.nih.gov/pubmed/20799507
tisdag 16 juni 2015
Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113605
Abstract
Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids (SFA) predict greater risk for developing type-2 diabetes and heart disease. These observations suggest a disconnect between dietary saturated fat and plasma SFA, but few controlled feeding studies have specifically examined how varying saturated fat intake across a broad range affects circulating SFA levels. Sixteen adults with metabolic syndrome (age 44.9±9.9 yr, BMI 37.9±6.3 kg/m2) were fed six 3-wk diets that progressively increased carbohydrate (from 47 to 346 g/day) with concomitant decreases in total and saturated fat. Despite a distinct increase in saturated fat intake from baseline to the low-carbohydrate diet (46 to 84 g/day), and then a gradual decrease in saturated fat to 32 g/day at the highest carbohydrate phase, there were no significant changes in the proportion of total SFA in any plasma lipid fractions. Whereas plasma saturated fat remained relatively stable, the proportion of palmitoleic acid in plasma triglyceride and cholesteryl ester was significantly and uniformly reduced as carbohydrate intake decreased, and then gradually increased as dietary carbohydrate was re-introduced. The results show that dietary and plasma saturated fat are not related, and that increasing dietary carbohydrate across a range of intakes promotes incremental increases in plasma palmitoleic acid, a biomarker consistently associated with adverse health outcomes.
Citation: Volk BM, Kunces LJ, Freidenreich DJ, Kupchak BR, Saenz C, Artistizabal JC, et al. (2014) Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome. PLoS ONE 9(11): e113605. doi:10.1371/journal.pone.0113605
Abstract
Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids (SFA) predict greater risk for developing type-2 diabetes and heart disease. These observations suggest a disconnect between dietary saturated fat and plasma SFA, but few controlled feeding studies have specifically examined how varying saturated fat intake across a broad range affects circulating SFA levels. Sixteen adults with metabolic syndrome (age 44.9±9.9 yr, BMI 37.9±6.3 kg/m2) were fed six 3-wk diets that progressively increased carbohydrate (from 47 to 346 g/day) with concomitant decreases in total and saturated fat. Despite a distinct increase in saturated fat intake from baseline to the low-carbohydrate diet (46 to 84 g/day), and then a gradual decrease in saturated fat to 32 g/day at the highest carbohydrate phase, there were no significant changes in the proportion of total SFA in any plasma lipid fractions. Whereas plasma saturated fat remained relatively stable, the proportion of palmitoleic acid in plasma triglyceride and cholesteryl ester was significantly and uniformly reduced as carbohydrate intake decreased, and then gradually increased as dietary carbohydrate was re-introduced. The results show that dietary and plasma saturated fat are not related, and that increasing dietary carbohydrate across a range of intakes promotes incremental increases in plasma palmitoleic acid, a biomarker consistently associated with adverse health outcomes.
Citation: Volk BM, Kunces LJ, Freidenreich DJ, Kupchak BR, Saenz C, Artistizabal JC, et al. (2014) Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome. PLoS ONE 9(11): e113605. doi:10.1371/journal.pone.0113605
fredag 12 juni 2015
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25458341
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R.
Diabetes Res Clin Pract. 2015 Jan;107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. Epub 2014 Oct 8.
PMID: 25458341
http://www.ncbi.nlm.nih.gov/pubmed/25458341
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R.
Diabetes Res Clin Pract. 2015 Jan;107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. Epub 2014 Oct 8.
PMID: 25458341
http://www.ncbi.nlm.nih.gov/pubmed/25458341
onsdag 3 juni 2015
Antitumor activity of astaxanthin and its mode of action. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/10798217
Antitumor activity of astaxanthin and its mode of action.
Jyonouchi H, Sun S, Iijima K, Gross MD.
Nutr Cancer. 2000;36(1):59-65.
PMID: 10798217
Jyonouchi H, Sun S, Iijima K, Gross MD.
Nutr Cancer. 2000;36(1):59-65.
PMID: 10798217
tisdag 26 maj 2015
fredag 22 maj 2015
EU har godkänt 17 genmodifierade växter
http://www.livsmedelsverket.se/om-oss/press/nyheter/pressmeddelanden/eu-har-godkant-17-genmodifierade-vaxter/
2015-05-22
EU-kommissionen har godkänt användningen av 17 genetiskt modifierade sorter av majs, soja, raps och bomull. De får användas till livsmedel och till foder. Godkännandet gäller import och bearbetning, men inte odling.
Produkterna tål vissa ogräsmedel eller insektsangrepp. Några av produkterna har bägge egenskaperna inbyggda. Flera av produkterna har ett tidigare godkännande, som nu har förlängts.
Majssorter
MON 87460,
NK 603
T25
Sojasorter
MON 87705,
MON 87769,
305423,
MON 87708,
GHB614XLLCotton25
BPS-CV127-9
Bomullsorter
MON 531xMON 1445,
MON 15985,
MON 88913,
T304-40,
MON 531,
MON 1445.
Rapssorter
MON88302
GT73.
Besluten sker i enlighet med Europaparlamentets och rådets förordning 1829/2003.
EU:s register över godkända GMO-produkter
http://ec.europa.eu/food/dyna/gm_register/index_en.cfm
2015-05-22
EU-kommissionen har godkänt användningen av 17 genetiskt modifierade sorter av majs, soja, raps och bomull. De får användas till livsmedel och till foder. Godkännandet gäller import och bearbetning, men inte odling.
Produkterna tål vissa ogräsmedel eller insektsangrepp. Några av produkterna har bägge egenskaperna inbyggda. Flera av produkterna har ett tidigare godkännande, som nu har förlängts.
Majssorter
MON 87460,
NK 603
T25
Sojasorter
MON 87705,
MON 87769,
305423,
MON 87708,
GHB614XLLCotton25
BPS-CV127-9
Bomullsorter
MON 531xMON 1445,
MON 15985,
MON 88913,
T304-40,
MON 531,
MON 1445.
Rapssorter
MON88302
GT73.
Besluten sker i enlighet med Europaparlamentets och rådets förordning 1829/2003.
EU:s register över godkända GMO-produkter
http://ec.europa.eu/food/dyna/gm_register/index_en.cfm
fredag 8 maj 2015
måndag 4 maj 2015
Entropy | Free Full-Text | Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
http://www.mdpi.com/1099-4300/15/4/1416
Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide....
Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.
--------
A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver...
It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut....
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism...
Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide....
Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.
--------
A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver...
It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut....
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism...
Samsel
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.
Environmental Sciences Europe | Full text | Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
http://www.enveurope.com/content/26/1/14
The results of the study presented here clearly indicate that lower levels of complete agricultural G herbicide formulations, at concentrations well below officially set safety limits, can induce severe hormone-dependent mammary, hepatic, and kidney disturbances.
The results of the study presented here clearly indicate that lower levels of complete agricultural G herbicide formulations, at concentrations well below officially set safety limits, can induce severe hormone-dependent mammary, hepatic, and kidney disturbances.
onsdag 29 april 2015
tisdag 28 april 2015
Microbiome | Full text | Being human is a gut feeling
http://www.microbiomejournal.com/content/3/1/9#
Some metagenomic studies have suggested that less than 10% of the cells that comprise our bodies are Homo sapiens cells. The remaining 90% are bacterial cells.
Some metagenomic studies have suggested that less than 10% of the cells that comprise our bodies are Homo sapiens cells. The remaining 90% are bacterial cells.
torsdag 16 april 2015
IJMS | Free Full-Text | Impacts of Gut Bacteria on Human Health and Diseases
http://www.mdpi.com/1422-0067/16/4/7493
Zhang Y-J, Li S, Gan R-Y, Zhou T, Xu D-P, Li H-B. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015; 16(4):7493-7519.
Abstract: Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.
Zhang Y-J, Li S, Gan R-Y, Zhou T, Xu D-P, Li H-B. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015; 16(4):7493-7519.
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