http://www.ncbi.nlm.nih.gov/pubmed/23993771
tisdag 26 maj 2015
fredag 22 maj 2015
EU har godkänt 17 genmodifierade växter
http://www.livsmedelsverket.se/om-oss/press/nyheter/pressmeddelanden/eu-har-godkant-17-genmodifierade-vaxter/
2015-05-22
EU-kommissionen har godkänt användningen av 17 genetiskt modifierade sorter av majs, soja, raps och bomull. De får användas till livsmedel och till foder. Godkännandet gäller import och bearbetning, men inte odling.
Produkterna tål vissa ogräsmedel eller insektsangrepp. Några av produkterna har bägge egenskaperna inbyggda. Flera av produkterna har ett tidigare godkännande, som nu har förlängts.
Majssorter
MON 87460,
NK 603
T25
Sojasorter
MON 87705,
MON 87769,
305423,
MON 87708,
GHB614XLLCotton25
BPS-CV127-9
Bomullsorter
MON 531xMON 1445,
MON 15985,
MON 88913,
T304-40,
MON 531,
MON 1445.
Rapssorter
MON88302
GT73.
Besluten sker i enlighet med Europaparlamentets och rådets förordning 1829/2003.
EU:s register över godkända GMO-produkter
http://ec.europa.eu/food/dyna/gm_register/index_en.cfm
2015-05-22
EU-kommissionen har godkänt användningen av 17 genetiskt modifierade sorter av majs, soja, raps och bomull. De får användas till livsmedel och till foder. Godkännandet gäller import och bearbetning, men inte odling.
Produkterna tål vissa ogräsmedel eller insektsangrepp. Några av produkterna har bägge egenskaperna inbyggda. Flera av produkterna har ett tidigare godkännande, som nu har förlängts.
Majssorter
MON 87460,
NK 603
T25
Sojasorter
MON 87705,
MON 87769,
305423,
MON 87708,
GHB614XLLCotton25
BPS-CV127-9
Bomullsorter
MON 531xMON 1445,
MON 15985,
MON 88913,
T304-40,
MON 531,
MON 1445.
Rapssorter
MON88302
GT73.
Besluten sker i enlighet med Europaparlamentets och rådets förordning 1829/2003.
EU:s register över godkända GMO-produkter
http://ec.europa.eu/food/dyna/gm_register/index_en.cfm
fredag 8 maj 2015
måndag 4 maj 2015
Entropy | Free Full-Text | Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
http://www.mdpi.com/1099-4300/15/4/1416
Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide....
Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.
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A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver...
It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut....
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism...
Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide....
Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.
--------
A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver...
It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut....
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism...
Samsel
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.
Environmental Sciences Europe | Full text | Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
http://www.enveurope.com/content/26/1/14
The results of the study presented here clearly indicate that lower levels of complete agricultural G herbicide formulations, at concentrations well below officially set safety limits, can induce severe hormone-dependent mammary, hepatic, and kidney disturbances.
The results of the study presented here clearly indicate that lower levels of complete agricultural G herbicide formulations, at concentrations well below officially set safety limits, can induce severe hormone-dependent mammary, hepatic, and kidney disturbances.
onsdag 29 april 2015
tisdag 28 april 2015
Microbiome | Full text | Being human is a gut feeling
http://www.microbiomejournal.com/content/3/1/9#
Some metagenomic studies have suggested that less than 10% of the cells that comprise our bodies are Homo sapiens cells. The remaining 90% are bacterial cells.
Some metagenomic studies have suggested that less than 10% of the cells that comprise our bodies are Homo sapiens cells. The remaining 90% are bacterial cells.
torsdag 16 april 2015
IJMS | Free Full-Text | Impacts of Gut Bacteria on Human Health and Diseases
http://www.mdpi.com/1422-0067/16/4/7493
Zhang Y-J, Li S, Gan R-Y, Zhou T, Xu D-P, Li H-B. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015; 16(4):7493-7519.
Abstract: Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.
Zhang Y-J, Li S, Gan R-Y, Zhou T, Xu D-P, Li H-B. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015; 16(4):7493-7519.
onsdag 15 april 2015
Dominic D'Agostino: Metabolic Therapies: Therapeutic Implications and Practical Application
Metabolic therapies that induce a state of mild ketosis from caloric restriction or the ketogenic diet offer neuroprotection against a wide range of pathologies, and continues to be an emerging strategy for the metabolic management of cancer. Severe dietary restriction of calories or carbohydrates is typically needed to produce a level of ketosis that achieves therapeutic benefits. Interestingly, the strategy to use exogenous ketones as an alternative fuel has not been exploited therapeutically. When administered orally in controlled dosages, ketone esters and other ketogenic agents can lower glucose and elevate plasma ketone levels comparable to levels achieved by the most rigorous ketogenic diets. Metabolic therapies in the form of ketone supplementation offer a safe, convenient, and versatile new treatment approach for a variety of diseases, including seizure disorders, neurodegenerative diseases and cancer.
Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial
http://www.biomedcentral.com/content/pdf/1743-7075-8-54.pdf
Conclusions:
"These pilot data suggest that a Ketogenic Diet is suitable for even advanced
cancer patients. It has no severe side effects and might improve aspects of
quality of life and blood parameters in some patients with advanced metastatic
tumors."
Schmidt et al.: Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutrition & Metabolism 2011 8:54
Schmidt et al.: Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutrition & Metabolism 2011 8:54
BMC Cancer | Full text | Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
http://www.biomedcentral.com/1471-2407/8/122
Abstract
Background
Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen. This phenomenon, known as aerobic glycolysis or the Warburg effect, may provide a rationale for therapeutic strategies that inhibit tumour growth by administration of a ketogenic diet with average protein but low in carbohydrates and high in fat enriched with omega-3 fatty acids and medium-chain triglycerides (MCT).
Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen. This phenomenon, known as aerobic glycolysis or the Warburg effect, may provide a rationale for therapeutic strategies that inhibit tumour growth by administration of a ketogenic diet with average protein but low in carbohydrates and high in fat enriched with omega-3 fatty acids and medium-chain triglycerides (MCT).
Methods
Twenty-four female NMRI nude mice were injected subcutaneously with tumour cells of the gastric adenocarcinoma cell line 23132/87. The animals were then randomly split into two feeding groups and fed either a ketogenic diet (KD group; n = 12) or a standard diet (SD group; n = 12) ad libitum. Experiments were ended upon attainment of the target tumor volume of 600 mm3 to 700 mm3. The two diets were compared based on tumour growth and survival time (interval between tumour cell injection and attainment of target tumour volume).
Twenty-four female NMRI nude mice were injected subcutaneously with tumour cells of the gastric adenocarcinoma cell line 23132/87. The animals were then randomly split into two feeding groups and fed either a ketogenic diet (KD group; n = 12) or a standard diet (SD group; n = 12) ad libitum. Experiments were ended upon attainment of the target tumor volume of 600 mm3 to 700 mm3. The two diets were compared based on tumour growth and survival time (interval between tumour cell injection and attainment of target tumour volume).
Results
The ketogenic diet was well accepted by the KD mice. The tumour growth in the KD group was significantly delayed compared to that in the SD group. Tumours in the KD group reached the target tumour volume at 34.2 ± 8.5 days versus only 23.3 ± 3.9 days in the SD group. After day 20, tumours in the KD group grew faster although the differences in mean tumour growth continued significantly. Importantly, they revealed significantly larger necrotic areas than tumours of the SD group and the areas with vital tumour cells appear to have had fewer vessels than tumours of the SD group. Viable tumour cells in the border zone surrounding the necrotic areas of tumours of both groups exhibited a glycolytic phenotype with expression of glucose transporter-1 and transketolase-like 1 enzyme.
The ketogenic diet was well accepted by the KD mice. The tumour growth in the KD group was significantly delayed compared to that in the SD group. Tumours in the KD group reached the target tumour volume at 34.2 ± 8.5 days versus only 23.3 ± 3.9 days in the SD group. After day 20, tumours in the KD group grew faster although the differences in mean tumour growth continued significantly. Importantly, they revealed significantly larger necrotic areas than tumours of the SD group and the areas with vital tumour cells appear to have had fewer vessels than tumours of the SD group. Viable tumour cells in the border zone surrounding the necrotic areas of tumours of both groups exhibited a glycolytic phenotype with expression of glucose transporter-1 and transketolase-like 1 enzyme.
Conclusion
Application of an unrestricted ketogenic diet enriched with omega-3 fatty acids and MCT delayed tumour growth in a mouse xenograft model. Further studies are needed to address the impact of this diet on other tumour-relevant functions such as invasive growth and metastasis.
Application of an unrestricted ketogenic diet enriched with omega-3 fatty acids and MCT delayed tumour growth in a mouse xenograft model. Further studies are needed to address the impact of this diet on other tumour-relevant functions such as invasive growth and metastasis.
PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522
Ketogenic Diet and HBO2T produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer. Our evidence suggests that these therapies should be further investigated as potential non-toxic treatments or adjuvant therapies to standard care for patients with systemic metastatic disease.
Ketogenic Diet and HBO2T produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer. Our evidence suggests that these therapies should be further investigated as potential non-toxic treatments or adjuvant therapies to standard care for patients with systemic metastatic disease.
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