måndag 29 september 2014
lördag 27 september 2014
KETOGENIC THERAPIES FOR...
KETOGENIC THERAPIES FOR
/
# Epilepsy
# Brain tumor/Cancer
# Autism
# Alzheimer's
# Traumatic brain injury
# Parkinsons’ disease
# Lou Gerhigs disease (ALS)
# Mitochondrial disorders
http://www.charliefoundation.org/
/
# Epilepsy
# Brain tumor/Cancer
# Autism
# Alzheimer's
# Traumatic brain injury
# Parkinsons’ disease
# Lou Gerhigs disease (ALS)
# Mitochondrial disorders
http://www.charliefoundation.org/
torsdag 25 september 2014
Everything You Know About Fat Is Wrong - The Daily Beast
http://thebea.st/1ni3z2b
Everything You Know About Fat Is Wrong
Think a low fat diet is the key to health? Think again.
Everything You Know About Fat Is Wrong
Think a low fat diet is the key to health? Think again.
tisdag 23 september 2014
Top 10 Facts You May Not Know About Your Diet | Nourishing Our Children
Top 10 Facts You May Not Know About Your Diet | Nourishing Our Children
- Eggs are healthy
- Butter is good for you
- Saturated fats and cholesterol are
vital for optimum health - Foods from grass-fed animals are
important for good health - Lean meat and low-fat milk should be
avoided - Modern soy products are dangerous
- Hydrogenated and liquid vegetable oils
contribute to heart disease and many other health problems - A vegan diet leads to serious
nutritional deficiencies - Not all “organic” foods are healthy
- Breakfast cereal is a junk food
tisdag 16 september 2014
Vitamin D deficiency: a worldwide problem with health consequences
Vitamin D deficiency: a worldwide problem with health consequences
Abstract
Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Very few foods naturally contain vitamin D, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement. Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults. Vitamin D deficiency has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases. A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D's beneficial effects for health. In the absence of adequate sun exposure, at least 800–1000 IU vitamin D3/d may be needed to achieve this in children and adults. Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations.
Abstract
Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Very few foods naturally contain vitamin D, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement. Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults. Vitamin D deficiency has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases. A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D's beneficial effects for health. In the absence of adequate sun exposure, at least 800–1000 IU vitamin D3/d may be needed to achieve this in children and adults. Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations.
tisdag 9 september 2014
Sammanställning (2014-09) av: Typ 1 Diabetes och "Low Carb"/"Ketogenic diet"
Effects of carbohydrate counting method on metabolic control in children with type 1 diabetes mellitus
http://www.ncbi.nlm.nih.gov/pubmed/24932599
Low carbohydrate diet in type 1 diabetes, long-term improvement and adherence: A clinical audit
http://www.dmsjournal.com/content/4/1/23
The ketogenic diet for the treatment of myoclonic astatic epilepsy in a child with type 1 diabetes mellitus.
http://www.ncbi.nlm.nih.gov/pubmed/25022865
Treatment of diabetes and diabetic complications with a ketogenic diet.
http://www.ncbi.nlm.nih.gov/pubmed/23680948
Assessment of diabetic nephropathy in the Akita mouse
http://www.ncbi.nlm.nih.gov/pubmed/22893398
Successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin
http://www.ncbi.nlm.nih.gov/pubmed/22250030
Type 1 diabetes and epilepsy: efficacy and safety of the ketogenic diet
http://www.ncbi.nlm.nih.gov/pubmed/20345934
Adults with type 1 diabetes eat a high-fat atherogenic diet that is associated with coronary artery calcium
http://www.ncbi.nlm.nih.gov/pubmed/19219420
Reconciling diabetes management and the ketogenic diet in a child with pyruvate dehydrogenase deficiency.
http://www.ncbi.nlm.nih.gov/pubmed/16901455
Nina Teicholz on Saturated Fats & the Soft Science on Fat – #149 | The Bulletproof Executive
Nina Teicholz on Saturated Fats & the Soft Science on Fat – #149 | The Bulletproof Executive
What You’ll Hear
- 0:07 – Cool Fact of the Day!
- 0:45 – Welcome Nina Teicholz
- 1:51 – Fat-powered astronauts and athletes
- 3:26 – Nina’s journey into studying fat
- 6:10 – Exploring the story of how fat got demonized
- 9:50 – Why our working hypothesis of health isn’t working
- 15:04 – The role of food companies in starting the fat scare
- 21:04 – A story of failed science and fat
- 27:15 – Problems with low-fat diets
- 32:56 – The health benefits of saturated fats
- 37:46 – The dangers of oxidized oils
- 43:38 – Ketogenic diets
- 47:02 – Low-fat foods in schools
- 52:15 – The slandering of tropical oils
- 53:56 – Are the food companies getting an unfair bad rap?
- 55:45 – The dietary double standard against fat
- 59:21 – Top three recommendations for kicking more ass and being Bulletproof!
tisdag 2 september 2014
lördag 30 augusti 2014
Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods
Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods
Introduction
Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric (Curcuma Longa Linn & zingiberaceae family), which is responsible for various pharmacological activities including anti-cancer, anti-oxidant, anti-bacterial, anti-fungal, anti-viral and anti-inflammatory and expected to have medicinal benefits in arthritis, psoriasis, diabetes, acquired immunodeficiency syndrome, cardiovascular diseases, multiple sclerosis, cancer and lung fibrosis.1,2 However, clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation in alkaline pH, metabolism via glucuronidation and sulfation in the liver and in intestine, and poor oral bioavailability. These limitations results in decreased therapeutic efficacy or absence of therapeutic efficacy in in-vivo studies.2 Though there are many novel approaches to overcome these limitations, nanotechnology (Particle size <1000 nm) is the most recent and offer significant improvement.3,4 Hence, to overcome these limitations we proposed to fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoformulation. However, unfavourable combinations of drug-drug and drug-excipient may result in interaction, which leads to physical instability or chemical instability. Physical instability refers to changes in the characteristics of a drug that do not involve chemical bond formation or breakage in the drug structure, which can be identified by changes in the organoleptic parameters such as appearance, form etc. Chemical instability refers to changes in the chemical structure of the drug molecule resulting in drug degradation, reduced drug content and formation of other molecule such as degradation products. Both physical and chemical instability may cause safety concerns. Hence, a thorough drug-drug/drug-excipient compatibility study is mandatory.5 The present study was aimed to assess the physical and chemical instability of curcumin with various excipients to be used in the proposed nanoformulations.
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